Production of the substitutional or forming acryl obturator is the widespread and available variant of the prosthetic rehabilitation of the oncological patients after the complex and reparative treatment. Those patients who don’t use acryl dentures and don’t have burdened background have microflora which consists mainly of round bacteria and fungi Candida, but level of biomarkers does not exceed the referential rate. Mucosa of oral cavity is the place ofprimary contact not only with aggressive parts of structurial substance of acryl obturator, antigens but with microorganisms waste products which are on it. Sutural connection is a hurt force for underlying saddle areas and additional reason for the process of cancer recurrence in patients with neoplasms of maxillofacial area.