Зависимость Антиноцицептивной Активности От Химической Структуры В Ряду

The screening of 7-(2-hydroxy-3-p-methoxyphenoxy)propyl-8-substituted theophylline was done. An effect on visceral nociceptors sensitivity was studied. A compound 5, that possesses antinociceptive activity that is comparable with the diclofenac activity, was detected. 7-(2-hydroxy-3-p-methoxyphenoxy)propyl-8-substituted theophylline is prospective group of compounds for further synthesis and researches of new pharmacological substances of a non-steroidal structure with antinociceptive properties.