The ROS is most problems in some disease and have major role disease development; DNA repair genes have been associated with different disease in addition to related with ROS, the present study aims to study ROS level with some DNA repair genes polymorphisms in patient with type 1 diabetes mellitus patients, the OGG1 Ser326Cys (rs1052133) and APE1 Asp148Glu (rs3136820), the results show that ROS level was significant elevation in patients 196.3600 ± 90.039 than control 95.37 ± 13.22, the genotyping of APE1 shows three genotyping (GT,GG and TT) with tow alleles (G and T), GT was low frequents in patients while TT was higher in patients than control in non-significant differences (p 0.38, 0.50) , T is more frequent in patients in addition to G was low frequent also in on significant differences (p 0.0513 ) in addition to deletion mutation which significant association with disease, OGG1 show strong association with disease, all patients have AC pattern which contributed in lowering ROS level, the present study concluded that the APE1 deletion mutation association with DM and didn’t relation with ROS level, OGG1 SER326CYS (RS1052133) strong association with DM and ROS level in type one of diabetes mellitus diseases.
分享
引用
