Nanotechnology is related to nanoparticles with sizes between 1-100 nm. With the increasing technology, the usage areas of nanoparticles are rapidly spreading and today they are encountered in different areas from medicine to food industry, from textile to drug development studies. Although there are different synthesis techniques of nanoparticles, it is more preferred to obtain them through green synthesis as it is a reliable and environmentally friendly method. Within the scope of the project, the behavioral toxicity of ZnO nanoparticles, which were previously obtained and characterized by green synthesis with Sideritis akmanii plant, an endemic species and known as mountain tea among the public, was investigated on a model organism, Drosophila melanogaster. In the evaluation of behavioral toxicity; parameters such as larval weight, larval crawling, pupa formation success, pupa position test and life span were used. In all studies, nanoparticle concentrations of 0.625, 1.25, 2.5 and 5 mg/ml were applied and the obtained data were evaluated statistically. According to the experimental results, a decrease in larval weight was detected due to the increase in concentration and this decrease was significant for the concentrations of 1.25, 2.5 and 5 mg/ml when compared to the control group statistically. The changes in larval crawling, exit success and lifespan were found to be statistically significant in the 5 mg/ml application for all three experiments when compared to the control group. As a result, in the light of all these data obtained, it was determined that ZnO nanoparticles caused behavioral changes in Drosophila melanogaster.
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