A 60-year-old man was evaluated at the hospital because of renal failure. He had been well until a trip to Colorado three months earlier; one week after returning he reported fatigue, edema, and a rash on his arms and legs. Laboratory evaluation revealed anemia, renal insufficiency, microscopic hematuria, and proteinuria. Serum complement levels were decreased. A skin biopsy showed leukocytoclastic vasculitis. Testing for cryoglobulins and antineutrophil cytoplasmic antibodies was negative. A diagnostic procedure was performed.