Proceedings for Annual Meeting of The Japanese Pharmacological Society（2022）
Pharmacol.
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摘要
Epithelial cells of exocrine glands responsible for saliva and tear secretion bear cell polarity. Cdc42, essential for the polarity of epithelial cells, is required for the formation and maintenance of luminal structures which is important site for the secretion. However, it is still unclear whether Cdc42 plays the identical role in different epithelial tissues in vivo. In this study, we generated exocrine epithelial cell-specific Cdc42 conditional knockout (KO) mice and analyzed the difference of Cdc42 roles between salivary glands and lacrimal glands.
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