This work tests and confirms the capability of the Particle Swam Optimization (PSO) algorithm to find the equalization coefficients used in High-Speed Serial Interfaces (HSIO) to compensate the channel frequency dependent losses. To test the algorithm, a HSIO system with a Feed-Forward Equalizer (FFE), Continuous Time Linear Equalizer (CTLE) and Direct Feedback Equalizer (DFE) were modeled and tested for channels with different losses. Results indicate that the PSO algorithm successfully obtain the optimal equalization coefficients simultaneously.