15431 Indirect Comparisons in Psoriasis: Implications for Clinical Practice

Objective: In moderate to severe plaque psoriasis (PsO), treatment decisions are becoming increasingly complex as the number of systemic therapeutic options and associated clinical studies grows. Head-to-head comparisons are not feasible for all therapies, so indirect comparison (IC) methodology is important to inform about the relative efficacy/safety of different drugs. We discuss potential implications of published ICs in PsO for clinical decision-making.