Merosesquiterpenes from the Marine Sponge Spongia Pertusa Esper and Their Antifungal Activities

Three new merosesquiterpenoids, 24-methylsulfinyllancoquinone B (1), pelorol A (2), and epi-langconol A (3), along with eight known related analogues, were isolated from a marine sponge Spongia pertusa Esper. The compounds were completely characterized by NMR spectroscopy and HRESIMS. Compound 1 had a friedo-drimane sesquiterpenoid skeleton bearing a rare 3-(methylsulfinyl)propan-1-amine func-tionality, whereas 2 and 3 were members of the drimane-type sesquiterpenoid derivatives. Compounds 1, 4, 6, 7, and 8 exhibited moderate antifungal activity against three human pathogens, namely, Candida albicans, Trichophyton mentaqrophytes, and Trichophyton rubrum, with MIC50 values ranging from 12.5 to 50 lg/mL. (c) 2022 Elsevier Ltd. All rights reserved.