Background and Purpose: Poor sleep quality is common among family caregivers and contributes to negative physical and mental health outcomes. This study examined the psychometric properties of the Pittsburgh Sleep Quality Index (PSQI) in caregivers of individuals with heart failure (HF) and Alzheimer's disease (AD). Methods: Baseline data from 269 family caregivers were used to assess the psychometric properties of the PSQI. Results: The PSQI showed acceptable reliability (Cronbach's α: HF = .76; AD = .74). Exploratory factor analysis supported a two-factor model in both groups, revealing both shared and condition-specific subscale loadings. Conclusion: Findings support the PSQI's reliability and construct validity in family caregivers, indicating its utility in identifying sleep disturbances in these high-risk populations.