Camellia yokdonensis is an endemic species in Vietnam. The present study reveals the composition of volatile compounds and antioxidant property of the ethanol extract obtained from the leaves of this plant. A total of eleven chemical components were identified in the leaf extract in which β-monolinolein (46.14%), glycerol β-palmitate (14.69%), phytol (11.99%), squalene (7.82%), γ-sitosterol (5.24%) are the major compounds. In addition, the studied extract also shows the potent DPPH free radical scavenging with the IC50 value of 6.04 μg/mL, comparable to the positive control vitamin C, which showed the IC50 value of 1.56 μg/mL.