OBJECTIVE:To explore the effect positions of the volatile anesthetic inhibiting the nociceptive reflex in the central nervous system.METHODS:Thirty adult SD rats were randomly and equally divided into two groups that the lip and hind paw of rats were held by clamp. The minimum alveolar concentration (MAC) was determined by clamping two places: one was to clamp the hind paw of rats, of which the nervous reflex is controlled via the spinal cord; the another group was to clamp the lip of rats, of which the nervous reflex is controlled through the brain stem.RESULTS:The isoflurane MAC was 1.44% +/- 0.09% in clamping the hind paw group, while 1.29% +/- 0.11% for clamping the lip group (P < 0.05).CONCLUSION:Both brain stem and spinal cord are the effect positions of volatile anesthetics (especially isoflurane).

目的:研究抗自由基药物对休克的治疗作用及机制.方法:采用家兔失血性休克模型,在失血前或再灌注前静脉注入别嘌呤醇,与单纯再灌组比较,通过测定血液及组织中反映氧自由基生成情况的XO活性、氧自由基破坏作用产物 MDA含量;机体抗自由基物质 SOD活性;血液动力学指标: HR,MAP,CO,LVSP,LV dp/dt max.结果:再灌后对照组血液及组织中XO活性、MDA含量较用药组明显升高、 SOD活性降低、用药组别嘌呤醇明显改善休克后血液动力学指标.结论:别嘌呤醇对失血性休克兔治疗有效,其作用机制与抑制黄嘌呤氧化酶,减少自由基生成有关.

Objective:To study the effects of panax pseudo-ginseng on the liver in rabbits suffered from SMAO shock.Methods:20 rabbits were divided randomly into control group and treatment group. SMAO (superior mesenteric artery occlusion)shock model was made by occluding the superior mesenteric artery for 1 hour. In treatment group, 200 mg/kg of panax pseudo-ginseng diluted in normal saline was given intravenously. In control group, the same volume of normal saline without drug was given intravenously. Mean blood pressures and 4-hour survival rates were monitored during the study. Biopsies from the left lobe of the liver were taken from all animals at the end of the study for microstructure study using electro-microscope.Results:Compared to control group, animals in the treatment group had a significant prolonged survival time and improved mean blood pressures. Impairment of hepatocytes in treatment group was significantly reduced. Conclusion: Panax pseudo-ginseng has benefit effects on the liver. This plays an important role in prolonging the survival time of the rabbits with SMAO shock.

近年来,一般中等以上非体外循环手术后血清钾降低已逐渐为人们所认识,但手术后三天内是否应常规补钾尚有不同意见。本研究通过对择期胆囊切除围手术期体钾变化的临床观察,探讨钾在细胞内外分布和摄入排出的关系、规律及机制,并探索术后合理补钾方案。

高渗NaCl能有效地改善失血性休克的血流动力学功能和提高存活率。目前用高渗NaCl治疗非失血性休克的研究尚未见报道。本文以家兔肠系膜上动脉夹闭（SMAO）性休克为模型,对比研究0.9％NaCl（NS）,6％右旋糖酐40（DS）,7.5％NaCl（HS）,含6％右旋糖酐40的7.5％NaCl（HSD）四种溶液的治疗效果,并对其作用机理进行探讨。

胸外电击除颤使用电能大小,尚无法提出固定数字;常倾向于认为越大效果越好。但在动物实验上,曾显示高电能似不如低电能更为有效。Weaver等,于1982年发表了249例在医院外发生的心跳骤停病例中,随机使用175瓦·秒或320瓦·秒的除颤效果。在其它复苏措施使用的同时,两组胸外电击除颤第一次的效果相同;皆有61％患者成

> 鼻咽纤维瘤是一种比较少见的病症,国内文献报告尚少,最近王鹏万及高荫藻二氏报告10例,并作精辟论述。本病患者多在少年发育时期,由于呼吸障碍及屡次出血结果,常致来诊时已有发育不良、极度贫血、营养状况恶劣之情形存在;同时更因手术摘除为目前唯一可靠之根本疗法,手术时常有大量出血