Vapor fluorination of 1,1,3,3-tetrachloropropene ( HCC-1230za) with HF to trans-1-chloro-3,3,3-trifluoropro-pene ( HCFO-1233zd( E) ) was investigated using the fluorinated Cr2O3 catalysts modified by Al3+, Zn2+, and Co2+. A highly active, selective, and long lifespan Zn/Cr2O3 catalyst was achieved for the first time, where 99.4％ HCC-1230za conversion and 98.2％ HCFO-1233zd (E) selectivity were obtained, and the selectivity to HCFO-1233zd (E) was favored at 200℃and HF/HCC-1230za molar ratio (10 : 1). The catalysts were characterized by XRD, XPS, BET, V70 pyridine adsorption infrared spectrometer and NH3-TPD techniques. The XRD results of catalysts Zn/Cr2O3 indicate that most of the amorphous chromium oxide and finely dispersed microcrystalline phase of Cr2O3 together lead to high activity and long lifespan. The con-version of HCC-1230za and the selectivity to HCFO-1233zd ( E) are related to the specific surface area of the fluorinated ca-talyst, and the higher the specific surface area of the catalyst, the higher selectivity. The XPS spectra of catalyst Zn/Cr2O3 show that exterior Cr2O3 after 118 h reaction formed CrOxFy species. The number and strength of Lewis and Br?nsted acid sites for Zn/Cr2O3 catalysts after 118 h reaction is significantly increased than the fresh one.

As one of the most aggressive malignancies, cervical cancer (CC) which mainly affects females has high risks of relapse and death. Long non-coding RNA (lncRNA) RP11-552M11.4 is verified to promote the progression of ovarian cancer; nevertheless, its role and the probable molecular mechanisms in CC remain unclear until the present study. Herein, we unveiled that the expression of lncRNA RP11-552M11.4 tested by qRT-PCR was enhanced in tumor tissues compared with the para-carcinoma tissues and related to FIGO Stage, lymph node metastasis, vascular invasion and distant metastasis in CC. Additionally, CC patients with high lncRNA RP11-552M11.4 level suffered from poor clinical outcomes. Moreover, silenced lncRNA RP11-552M11.4 restrained cell proliferation, migration and invasion in CC cells. Subsequently, the mechanistic studies revealed that lncRNA RP11-552M11.4 functioned as a ceRNA of ATF1 in CC by acting as the endogenous sponge for miR-3941, which was identified as a tumor suppressor in CC. Moreover, both miR-3941 inhibition and ATF1 overexpression restored the impacts of inhibited lncRNA RP11-552M11.4 on cellular processes in CC cells. Our observations elucidated the carcinogenic role of lncRNA RP11-552M11.4 in CC was mediated through miR-3941/ATF1 axis, giving a new insight into the effective target for the treatment and prognosis of cervical cancer.

简述了常州市在经济发展过程中出现的环境污染问题,以及常州市对环境污染进行综合治理所采取的措施,为今后的可持续发展打下了坚实的环境基础。