アミノグリコシド系薬剤による難聴の家系において, ミトコンドリア遺伝子12S rRNA領域の961delTとA1555G変異が報告されている。 今回, ストレプトマイシン難聴患者に遺伝子解析を行ったところ, 対象9例中1例に961delT変異 (11%), 6例にA1555G変異 (67%) を認めた。 961delT変異例の聴力像は, 両側対称性の中等度感音性難聴で, 内耳性障害と考えられた。 A1555G変異例のうち4例は高度以上の感音性難聴で, その2例は人工内耳装用者であった。 問診に加え, これらの変異をスクリーニングすることが, アミノグリコシド系薬剤による難聴の減少に貢献する可能性があり, 有用な検査であると考える。 また, 今回は口腔粘膜擦過細胞や尿沈査を検体として用いており, 非常に侵襲性が少なく, 小児例にも施行しやすい方法であった。

Three hundred and ninety-three patients (292 male and 101 female) who visited our clinic complaining of snoring and/or apnea during sleep were evaluated for sleep apnea syndrome (SAS) by Apnomonitor screening. A total of 131 patients (114 male and 17 female) showed an apnea index (A. I.) higher than to apnea episodes/hour, and there was a significant correlation of the A. I. with age, sex, and body mass index (BMI) in these patients. All patients with severe SAS (more than 50 apnea episodes/hour) were men, who had a BMI greater than 25, with the exception of 1 patient. Significantly higher ages and BMI were found to exist in patients with SAS than in those without SAS.

A new method for measuring the rate of movement of sand using an He–Ne laser beam has been developed. This method enables us to measure the velocity of blown sand in the field. The apparatus is composed of an He–Ne laser, a photo-detection system (slit width; 0.3–3.0 mm), a 5-channel pulse width analyzer and a multi-purpose counter. When a sand grain passes across the laser beam, a shadow is thrown upon the light-sensitive surface of the photodetector. The change in photocurrent, after amplification and pulse shaping, is fed to the pulse width analyzer. The pulse width includes information on both the velocity and size of the blown sand grains. Using a nearly uniform size of sand grains, the velocity distribution of blown sand can be measured.

The photoionization process of indole in alkaline aqueous solutions at 77°K and the recombination process of trapped electron with its mother molecule were investigated. The fluorescence spectrum of indole in these glassy media depended on the NaOH concentration; the disappearance of the 325 nm band at the NaOH concentrations higher than 5 M with the appearance of a fluorescence band at 375 nm. The latter emission is possibly ascribed to the fluorescence of indole anion formed by proton dissociation in the excited singlet state of indole. The intensities of the 375 nm band and the ESR signal due to trapped electrons were dependent on the NaOH concentration and increased steeply with increasing the NaOH concentration. There was a parallel relation between the indole anion concentration and the trapped electron density to some extent. The dependence of the ESR signal intensity on irradiation intensity suggested that the photoionization of indole in alkaline aqueous solution occurred through a two photon process. The presence of a photoactive intermediate for absorbing the second photon was further investigated with simultaneous irradiation of two different wavelength lights. The trapped electron was detrapped with the irradiation of visible light (e.g. 580 nm), and its recombination with mother molecule caused an emission with the same spectrum as indole phosphorescence. The molecular species of the photoactive intermediate in alkaline aqueous solutions seems to be the indole anion. The photoionization in NaOH aqueous solution at 77°K was also compared with that in methanolic glassy solution.

Chemischer InformationsdienstVolume 7, Issue 23 Preparative Organic Chemistry ChemInform Abstract: Photoionization of Indole in Alkaline Aqueous Solutions at 77° K (Phosphoreszenz- Spektren, Fluoreszenz, ESR). SHOZI YAMASHITA, SHOZI YAMASHITASearch for more papers by this authorMIZUKI YOSHIDA, MIZUKI YOSHIDASearch for more papers by this authorGIITI TOMITA, GIITI TOMITASearch for more papers by this author SHOZI YAMASHITA, SHOZI YAMASHITASearch for more papers by this authorMIZUKI YOSHIDA, MIZUKI YOSHIDASearch for more papers by this authorGIITI TOMITA, GIITI TOMITASearch for more papers by this author First published: June 8, 1976 https://doi.org/10.1002/chin.197623107AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume7, Issue23June 8, 1976 RelatedInformation

The e.m.f. (electromotive force) change of sodium sensitive glass electrode was measured in the buffered solution in the process of neutralization with sodium hydroxide. Just above the neutral point where the sodium ion concentration was kept constant, a sudden change of e.m.f. was observed. This phenomenon was explained with respect to the phase boundary ion exchange hypothesis. The data obtained were compared with Nicolsky's simple and generalized theories which succussfully explained e.m.f. changes of various glass electrodes. But, Nicolsky's equations failed in giving an appropriate value of the slope in the plot of e.m.f. versus log CNa.