Enramycin is used as a dietary antimicrobial in young animals, but its effects on rabbit colonic ecology remain insufficiently characterized. This study evaluated the effects of enramycin in 60 weaned rabbits randomly assigned to a control or enramycin-treated group (60 mg/kg) for 14 days (n = 30/group). Clinical outcomes were evaluated in all rabbits, whereas paired colonic multi-omics profiling was performed in six randomly selected survivors per group with no recorded diarrhea. Enramycin reduced diarrhea incidence without affecting body-weight development, organ indices, or mortality. Metagenomic analysis revealed unchanged alpha diversity but significant alterations in microbial community structure, including decreased Verrucomicrobiota, Akkermansia, and Alistipes and increased Cyanobacteria and Avigastranaerophilus. Untargeted metabolomics identified 332 features meeting the predefined screening criteria, including 143 upregulated and 189 downregulated metabolites. Prominent pathway annotations included phenylpropanoid biosynthesis and arachidonic acid metabolism. Resistome analysis demonstrated that treatment drove shifts in streptothricin-, aminoglycoside- and glycopeptide-related resistance signatures. The integrated analysis identified associations between four selected genera and the top 30 differential metabolites. Overall, dietary enramycin was associated with a short-term reduction in diarrhea incidence and concurrent changes in selected colonic microbial, metabolic, and resistance gene features. These findings extend enramycin evaluation beyond conventional clinical outcomes and highlight the importance of considering broader ecological effects when assessing dietary antimicrobial exposure in weaned rabbits.

Proteomics has been widely used to identify proteins in the milk fat globule membrane (MFGM). However, the characteristics of MFGM proteins in rabbit colostrum (RC) and mature milk (RM) remain largely unexplored. This study aimed to profile the rabbit MFGM proteins and assess differences in component and functional profiles between RC and RM through data-independent acquisition (DIA) quantitative proteomics. We established the proteomic profile of rabbit MFGM, identifying 3,548 proteins across RC and RM. Notably, typical MFGM proteins, such as Perilipin 2 (PLIN2), Xanthine dehydrogenase/oxidase (XDH/XO), and Apolipoprotein, were detected in rabbit milk, and 10 of these were confirmed by Parallel reaction monitoring (PRM) detection. Comparative analysis revealed 480 differentially expressed MFGM proteins (DEMPs), with 379 up-regulated and 101 down-regulated DEMPs in RC compared to RM. This included 68 unique proteins in RC, 5 in RM, and 407 DEMPs expressed in both groups. The GO analysis indicated that DEMPs are predominantly involved in processes such as proteolysis, cell adhesion, and ion transport, with enrichments of 32, 14, and 14 DEMPs, respectively. KEGG analysis gathered 56 significant pathways, most of which were categorized into Human Diseases (20/56) and Metabolism (14/56). Protein-protein interaction (PPI) network analysis emphasized the core role of DEMPs (e.g., proteasome subunits and integrins) in human diseases (e.g., Alzheimer's disease) and in signal transduction (e.g., the PI3K-Akt signaling pathway). These results offer theoretical insights into the components and functions of rabbit milk, suggesting a novel way to enhance the economic benefit of the rabbit industry.

Understanding the molecular basis of rabbit meat quality is essential for genetic improvement. We compared Sichuan White (S) and New Zealand White (N) rabbits using carcass phenotyping (n = 20), longissimus dorsi transcriptomics (n = 3), and 4D-DIA proteomics (n = 3). Differentially expressed genes (DEGs) were identified using |log₂FoldChange| ≥ 0.3693 and p < 0.05, and differentially expressed proteins (DEPs) were determined using fold change ≥ 1.3 or ≤ 0.7692 and p < 0.05. S rabbits exhibited lower drip loss and shear force but higher intramuscular fat (IMF) content, despite N rabbits displaying greater carcass yield. Integrated omics analysis revealed 848 differentially expressed genes and 140 differentially expressed proteins. The IMF accumulation in S rabbits was driven by upregulated lipid biosynthesis and suppressed fatty acid oxidation. Enrichment of oxidative phosphorylation and thermogenesis indicated enhanced mitochondrial coupling and redox balance, supporting water-holding capacity. Upregulation of ECM-related integrin β-subunits was correlated with improved tenderness. Sixty-eight KEGG pathways were co-enriched across omics layers, highlighting the interplay of lipid metabolism, mitochondrial function and ECM remodeling. Integrated transcriptomic and proteomic analyses revealed that upregulated lipid biosynthesis, suppressed fatty acid oxidation, and enhanced ECM-receptor signaling jointly contribute to superior meat quality in S rabbits. These findings provide candidate molecular targets for improving native rabbit meat quality and offer a foundation for future marker-assisted selection after validation in independent populations.

The rising global demand for high-quality animal protein has driven the development of advanced technologies in high-density livestock farming. Rabbits, with their rapid growth, high reproductive efficiency, and excellent feed conversion, play an important role in modern animal agriculture. However, large-scale rabbit farming poses challenges in timely health inspection and environmental monitoring. Traditional manual inspections are labor-intensive, prone-to-error, and inefficient for real-time management. To address these issues, we propose Livestock Environmental Monitoring System–Gantry (LIVEMOS-G), an intelligent gantry-based monitoring system tailored for large-scale rabbit farms. Inspired by plant phenotyping platforms, the system integrates a three-axis motion module with multi-source imaging (RGB, depth, near-infrared, thermal infrared) and an environmental sensing module. It autonomously inspects around the farm, capturing multi-angle, high-resolution images and real-time environmental data without disturbing the rabbits. Key environmental parameters are collected accurately and compared with welfare standards. After training on an original dataset, which contains a total of 2325 sets of images (each set includes RGB, NIR, TIR, and depth image), the system is able to detect dead rabbits using a fusion-based object detection model during inspections. LIVEMOS-G offers a scalable, non-intrusive solution for intelligent livestock inspection, contributing to enhanced biosecurity, animal welfare, and data-driven management in high-density, modern rabbit farms. It also shows the potential to be extended to other species, contributing to the sustainable development of the animal farming industry as a whole.

This study aimed to investigate the effects of short-term exposure of Bisphenol A (BPA) on the growth and lactation performance, blood parameters, and milk composition of lactating rabbits and explore its potential molecular mechanisms. Eight lactating rabbits with similar body weight were selected and randomly divided into the experimental group (BPA) and the control group (Ctrl). The group BPA was orally administered 80 mg/kg/day BPA on the 15th day postpartum, while the group Ctrl received a corresponding volume of vehicle. Blood and milk samples were collected after 7 days treatment. The results showed that short-term ingestion of BPA did not obviously alter the body weight, feed intake, or milk yield of the lactating rabbits. ELISA assays indicated that BPA did not significantly affect the plasma levels of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), creatinine (CRE), alanine aminotransferase (ALT), aspartate aminotransferase (AST), uric acid (UA), and urea. Utilizing untargeted metabolomics, we first depicted the metabolomic profile of rabbit milk, and identified 277 differential metabolites (DMs), with 141 DMs upregulated (e.g., BPA, and its metabolites including Cetirizine N-oxide) and 136 DMs downregulated (e.g., Oleamide, Tiglic acid, PC O-38:4) in the group BPA. KEGG analysis revealed that the DMs were mainly enriched in pathways comprising fatty acid metabolism, fatty acid degradation, and phosphatidylinositol signaling system, emphasizing the effect of BPA on milk fat metabolism. Hence, we established the BPA-induced MAC-T model, and the results showed that BPA significantly reduced cell viability and impacted lipid synthesis, as evidenced by reduced lipid droplets (BODIPY and Oil Red O staining) and decreased expression of genes related to lipid synthesis (e.g., PPARγ, ACACA, LPL). In summary, we first drew the metabolomic profile of rabbit milk and confirmed that short-term BPA exposure impacted mammary lipid synthesis, thereby reducing the milk quality of lactating rabbits and providing fundamental data for resolving the toxicological mechanisms of BPA on mammal lactation.

This study aims to investigate the potential regulatory network responsible for the meat quality using multi-omics to help developing better varieties. Slaughter performance and meat quality of Shuxing No.1 rabbit outperformed IRA rabbit according to the tested rabbit parameters. Differentially expressed genes (DEGs) and differentially abundance proteins (DAPs) were involved in meat quality-related pathways, such as PI3K - Akt and MAPK signaling pathways. Only SMTNL1 and PM20D2 shared between DEGs and DAPs. Olfactory-sensitive undecanal, a differentially abundant metabolite (DAM) in volatilomics (vDAMs), correlated with all of the remaining 11 vDAMs, and most of 12 vDAMs were associated with amino acid metabolism. Integration revealed that 829 DEGs/DAPs were associated with 15 DAMs in four KEGG pathways, such as melatonin (a DAM in widely targeted metabolomics) was significantly positively correlated with ALDH and negatively correlated with RAB3D and CAT in the tryptophan metabolism pathway. This study sheds light on the potential mechanisms that contribute to the improved meat quality and flavor. SIGNIFICANCE: Shuxing No.1 rabbit is a new breed of meat rabbit in the Chinese market. In meat marketing, meat quality usually determines the purchase intention of consumers. Determining the biological and molecular mechanisms of meat quality in meat rabbit is essential for developing strategies to improve meat quality. According to the tested rabbit parameters, this study ascertained that the slaughter performance and meat quality of Shuxing No.1 rabbit surpasses that of IRA rabbit. The present study profiled the transcriptome, proteome, widely targeted metabolome, and volatilome of longissimus dorsi from Shuxing No.1 rabbit and IRA rabbit. The study found that meat quality and flavor-related tryptophan metabolism pathway is enriched with many DEGs/DAPs (including ALDH, RAB3D, and CAT), as well as a DAM, melatonin. This study sheds light on the potential mechanisms that contribute to the improved meat quality and flavor.

试验旨在研究饲粮中添加参杞颗粒对四川白兔生长性能、免疫功能的影响,进一步评估其在四川白兔上的应用效果.选择180只35日龄健康且体重相近的四川白兔,随机分为5组,每组18个重复,每个重复2只(公母各半).对照组饲喂基础饲粮(不添加任何抗生素),阳性组在基础饲粮中添加1％的黄芪多糖,试验低、中、高剂量组在基础饲粮中分别添加0.5％、1.0％、1.5％参杞颗粒的试验饲粮饲喂.预试期7 d,正试期28 d.结果显示:饲粮中添加0.5％～1.5％的参杞颗粒能够提高肉兔的平均日增重、降低其料重比,其中试验高剂量组与对照组差异显著(P＜0.05).与对照组相比,饲粮中添加1.0％的参杞颗粒相较于对照组能够提高四川白兔的免疫器官指数,但差异并不显著.综合考虑所测指标,在试验的3个参杞颗粒添加量中以1.0％的效果最好.

本试验旨在探讨燕麦干草和苜蓿干草的组合效应对肉兔生长性能、饲粮养分表观消化率、血清生化指标和肠道发育的影响.选择28日龄的体重相近的新西兰白兔600只,随机分为5组,每个组设置6个重复,每个重复内20只肉兔,公母各占1/2.配制燕麦干草和苜蓿干草之和占比为28％的5种试验饲粮,其中对照组饲粮中燕麦干草:苜蓿干草为0:4,试验Ⅰ、Ⅱ、Ⅲ和Ⅳ组饲粮中燕麦干草:苜蓿干草分别为1∶3、1∶1、3∶1和4∶0.预试期7 d,正试期35 d.结果显示:1)试验Ⅰ组末重和平均日增重显著高于对照组、试验Ⅲ和Ⅳ组(P＜0.05),料重比显著低于对照组、试验Ⅲ和Ⅳ组(P＜0.05);各组之间平均日采食量、腹泻率和死亡率差异不显著(P＞0.05).2)各组之中以试验Ⅰ组饲粮各养分表观消化率最高,且试验Ⅰ组的饲粮能量、粗蛋白质、干物质和中性洗涤纤维表观消化率显著高于试验Ⅲ和Ⅳ组(P＜0.05).3)各组之间血清总蛋白、白蛋白、尿素氮、葡萄糖含量与碱性磷酸酶、谷草转氨酶、谷丙转氨酶活性无显著差异(P＞0.05).4)试验Ⅰ组十二指肠、空肠绒毛高度显著高于试验Ⅳ组(P＜0.05),绒隐比显著高于对照组、试验Ⅲ和Ⅳ组(P＜0.05).由此可见,肉兔饲粮中燕麦干草和苜蓿干草的最佳组合比例为1:3,其可促进肠道发育,提高饲粮养分消化率,进而提高肉兔的生长性能.

选用体重相近的35日龄断奶新西兰肉兔150只,随机分成5个组,分别为对照组、试验1、2、3、4组,对照组添加氯苯胍150 mg/kg,试验1、2、3组分别添加Es-ap、Em-mg、Ei-ma卵黄抗体1 g/kg,试验4组添加上述3种球虫重组蛋白复合卵黄抗体1 g/kg(各占1/3),每组设5个重复,每个重复6只,分别饲喂对应日粮,并于42日龄人工感染攻虫.试验结果显示,试验4组在平均日增重、日采食量、成活率方面均显著高于其他组别(P＜0.05),料肉比显著低于其他组别(P＜0.05);抗球虫指数(ACI)值判定标准为:Es-ap、Em-mg、Ei-ma卵黄抗体均具有中等抗球虫效果,3种卵黄抗体组合使用,具有良好的抗球虫效果.结论:筛选的兔球虫重组蛋白抗原制备卵黄抗体(IgY)不仅对兔球虫具有良好的免疫保护作用,不同虫种还具有交叉免疫保护力.

This experiment was conducted to study the effects of Zanthoxylum schinifolium leaf powder on the growth performance, small intestinal development, slaughter performance and meat quality of meat rabbits. Six hundred 28-day-old “Shuxing No.1” commercial meat rabbits with similar body weight were randomly divided into 5 groups with 6 replicates in each group and 20 rabbits（half male and half female） in each replicate. Rabbits in the 5 groups were fed diets containing 0（control group）, 3%, 6%, 9% and 12% Zanthoxylum schinifolium leaf powder, respectively. The pre-feeding period was 7 days and the trial period was 42 days. The results showed as follows: 1) with the increase of Zanthoxylum schinifolium leaf powder supplemental level, the average daily feed intake and average daily gain of rabbits showed a trend of first increasing and then decreasing, and the 6% group had the highest values, which were significantly higher than those in the control group and other experimental groups（P＜0.05）; the feed to gain ratio showed a trend of first decreasing and then increasing, and the 12% group was significantly higher than the control group, 3% group and 6% group（P＜0.05）; the diarrhea rate and mortality showed a trend of decreasing gradually, and the 12% group was significantly lower than the control group（P＜0.05）. 2) The ratio of villus height/crypt depth of duodenal mucosa in the 6% group was significantly lower than that of the control group（P＜0.05）; the amylase activity of jejunum in 9% group and 12% group was significantly lower than that of the control group（P＜0.05）; the trypsin activity of jejunum in 12% group was significantly lower than that of the control group（P＜0.05）. 3) With the increase of Zanthoxylum schinifolium leaf powder supplemental level, the live weight before slaughter, half eviscerated weight, full eviscerated weight, half eviscerated dressing percentage and full eviscerated dressing percentage showed a trend of first increasing and then decreasing, the slaughter performance of 6% group was the best, followed by 3% group, control group, 9% group and 12% group. 4) With the increase of Zanthoxylum schinifolium leaf powder supplemental level, the pH 24 h , ether extract and inosinic acid contents of longissimus dorsi increased firstly and then decreased, the redness（a * ） increased gradually, and the drip loss decreased firstly and then increased. Among them, the 6% group had the highest pH 24 h , ether extract and inosinic acid contents, and the lowest drip loss. In summary, adding an appropriate proportion of Zanthoxylum schinifolium leaf powder in the diet of rabbits can increase the feed intake and growth rate of meat rabbits, promote small intestinal mucosa development, increase jejunal digestive enzyme activities, improve slaughter rate and meat quality, and the appropriate supplemental level is 6%.

12022年四川兔业特点、问题 1.1 遭受60年一遇高温,母兔存量大幅下降 2022年四川遭受60年一遇高温,全省电力供应严重不足,8月份全省工业企业停产半个月,居民生活和商业用电也受到影响.在大环境缺电的情况下,肉兔养殖用电更加紧张,养殖户因缺电损失惨重.据不完全统计,能繁肉兔存栏减少30%～40%,秋繁时间严重滞后.饲养管理岗位在自贡市的精液品质监测表明,到10月下旬公兔精液品质才逐渐恢复,秋繁较往年推迟1个月,秋繁效果不理想.

兔肉具有高蛋白、高赖氨酸、高磷脂、低脂肪、低胆固醇和低热量的特点,符合绝大多数人对肉品质的需求,越来越受到人们关注.兔肉品质主要包括肉色、pH值、系水力、肌内脂肪(IMF)、风味和嫩度等几个方面.肉品质受到遗传、营养等多种因素的影响,近年来国内外研究表明,通过遗传调控和营养调控来改善兔肉品质,是一条切实可行的途径.文章讨论了肌肉组成影响兔肉品质的机制,并在此基础上综述了遗传因素和营养因素对改善兔肉品质的研究进展.

试验旨在研究日粮中添加不同水平的桑枝茎叶粉对母兔繁殖性能的影响.选择第3胎空怀新西兰母兔400只,随机分为4组,每组5个重复,每个重复20只.各组分别饲喂桑枝茎叶粉添加量为0(对照组)、8％、16％、24％的日粮.预试期10 d,试验期从母兔配种前15 d至仔兔断奶结束.结果表明:日粮中添加桑枝茎叶粉对母兔空怀期采食量无显著影响,24％桑枝茎叶粉组母兔妊娠期和泌乳期采食量均低于对照组和8％桑枝茎叶粉组(P<0.05);桑枝茎叶粉对母兔发情率、受胎率、死胎率、仔兔初生窝重、21 d窝重、断奶窝重和断奶仔兔数等繁殖泌乳指标无显著影响,但随着添加水平的增加,母兔繁殖和泌乳性能逐渐降;24％桑枝茎叶粉组母兔产活仔数低于对照组和8％桑枝茎叶粉组(P<0.05),16％桑枝茎叶粉组和24％桑枝茎叶粉组间无显著差异.本试验条件下,母兔日粮中桑枝茎叶粉的添加量不宜超过16％.

2020年7月1日,我国施行饲料全面禁抗.本文就无抗形势下如何提高商品兔生产性能进行系统介绍,供广大养兔场(户)参考. 1商品兔的饲养管理策略 1.1断奶日龄 在"饲料无抗"条件下,推荐仔兔断奶日龄为35日龄.仔兔断奶日龄越大,断奶体重会越重,机体抵抗力会越强,发生腹泻死亡的几率会降低,育肥期的成活率会大大提升.同时,推行分批次断奶策略,同一窝仔兔体重小的、体质弱的采用寄养方式延迟断奶.

The purpose is to study the effects of different doses of medium chain triglyceride (MCT) on growth performance, immune and oxidative functions, and intestinal health of weaned rabbits. A total of 600 weaned rabbits weighing about 993.26 g and at 35 d of age were randomly divided into five groups. The control group was fed a basal diet containing 2400 mg/kg soybean oil, and the experimental group was substituted with 600, 1200, 1800, and 2400 mg/kg MCT. The whole trial period lasted for 48 d. The results showed that treatment with 2400 mg/kg MCT significantly increased the weaning survival rate and crude fat digestibility (p < 0.05) and dramatically raised the levels of serum immunoglobulin (Ig)A, IgG, IgM, catalase, superoxide dismutase, and total antioxidant capability (p < 0.05). The villus height and crypt depth in 1800 mg/kg MCT group were observably enhanced (p < 0.05). The abundance of Bacteroidetes was significantly increased in 1800 and 2400 mg/kg MCT groups (p < 0.05). In conclusion, 1800 and 2400 mg/kg MCT substituting soybean oil in the diet of weaned rabbits can improve the growth performance and intestinal barrier function of weaned rabbits.

为研究饲粮添加不同水平青花椒叶对肉兔生产性能、养分表观消化率和血清生化指标的影响,试验选择28日龄体重相近的新西兰兔600只,随机分成4个处理,每个处理5个重复,每个重复30只,公母各半.对照组饲喂基础日粮,试验组分别饲喂含4％、8％和12％青花椒叶粉的饲粮.预饲期7 d,正试期42 d.结果表明:随着青花椒叶添加量的增加,肉兔采食量和日增重呈现先增加后减少的趋势,4％组显著高于对照组(P<0.05),但与8％组差异不显著(P>0.05);添加青花椒叶对饲粮中干物质、粗蛋白质、粗脂肪和粗纤维的表观消化率无显著影响(P>0.05),随着添加量的增加,饲粮能量和无氮浸出物的表观消化率呈先升高后降低的趋势,其中4％组最高,但与8％组差异不显著(P>0.05);血清血糖、总胆固醇、甘油三酯和低密度脂蛋白随着饲粮中青花椒叶添加量的增加呈逐渐降低的趋势,其中12％组显著低于对照组(P<0.05).综上所述,在肉兔饲粮中添加青花椒叶可以改善饲粮适口性,促进养分消化,提高生产性能,降低血清血糖和血脂,本试验条件下,肉兔饲粮中青花椒叶的添加量不宜超过8％.

实验旨在探索制定蜀兴1号肉兔达2 000 g体重日龄的生长性状校正公式,为生产中明确其适宜出栏时间提供参考.以352只28日龄断奶的蜀兴1号商品代肉兔为研究对象,每周测定一次体重,直至84日龄结束,搜集体重和日龄数据,利用Logistic、Gompertz和Von Bertallanffy 3种非线性动物生长模型进行生长曲线拟合,并进一步以拟合效果最好的模型为基础,制定生长性状校正公式.结果表明:3种生长曲线模型的拟合度分别为0.980 9、0.982 4和0.981 7(P<0.01),拟合效果均较好,基于拟合度最高的Gompertz模型制定的蜀兴1号肉兔达2 000 g体重日龄的生长性状校正公式为:t校正=t实1.7375/(1.4214–ln(8.3299–lny实)),其中t校正为校正日龄,t实为实测日龄,y实为实测体重,实测体重在1 674.33~2 464.67 g之间时校正效果良好,根据校正公式获得的蜀兴1号肉兔达2 000 g体重的时间为64.52 d.研究表明,利用生长曲线开展肉兔生长性状校正公式的制定是可行的,蜀兴1号肉兔的适宜出栏时间为65 d.

本试验旨在研究茶叶渣替代麸皮对肉兔生长性能、屠宰性能和肉品质的影响.试验选择28日龄体重相近的新西兰兔480只,随机分成4个组,每组5个重复,每个重复24只(公母各占1/2).对照组饲喂基础饲粮,试验组分别以10％、15％和20％茶叶渣替代等比例麸皮.预试期7 d,正试期42 d.结果表明:1)与对照组相比,10％茶叶渣替代组的终末体重、平均日增重、平均日采食量、料重比、腹泻率和死亡率无显著差异(P>0.05);20％茶叶渣替代组的终末体重、平均日增重、平均日采食量显著下降(P<0.05),且料重比显著升高(P<0.05).2)与对照组相比,10％茶叶渣替代组的宰前活重、全净膛重和半净膛重无显著差异(P>0.05),但15％和20％茶叶渣替代组的宰前活重、全净膛重和半净膛重显著降低(P<0.05).3)与对照组相比,10％和15％茶叶渣替代组的肌肉pH24h和滴水损失无显著差异(P>0.05);20％茶叶渣替代组的肌肉pH24 h显著降低(P<0.05),且肌肉滴水损失显著提高(P<0.05).4)与对照组相比,10％和15％茶叶渣替代组的肌肉水分、粗蛋白质和粗脂肪含量无显著差异(P>0.05),但20％茶叶渣替代组的肌肉粗脂肪含量显著降低(P<0.05).综上所述,在肉兔饲粮中以10％茶叶渣替代等比例麸皮对肉兔的生长性能、屠宰性能和肉品质无不利影响.

BackgroundThe chorion from the placenta is directly attached to the endometrium (CA) after embryo implantation while some parts of the endometrium are not chorion-attached (NCA). The differences in gene expression between the CA and NCA endometrium mid-gestation are unknown. Our objective was to compare the gene expression profiles of the CA and NCA endometrium of rabbit, to identify the differentially expressed genes (DEGs), and correlate the differences with the physiological state of the endometrium at mid-gestation of rabbit.MethodsWe used transcriptome sequencing to reveal the differences in gene expression between CA and NCA endometrium (n = 3), and then determined the concentration of inflammatory cytokines in CA and NCA tissue and serum by ELISA.ResultsSix Hundred and Forty-Six DEGs were identified between the CA and NCA endometrium [p < 0.05, |log2 (fold change) |≥ 2], The expression levels of 590 DEGs were higher in the NCA endometrium than in the CA endometrium, while the expression level of only 56 DEGs were higher in CA than in NCA. The DEGs were enriched in gene ontology (GO) terms and pathways related to immune regulation and cellular adhesions. Six hub-genes related to inflammatory mediator regulation of transient receptor potential (TRP) channels and chemokine signaling pathways had a lower expression level in the CA endometrium compared to the NCA endometrium, and the expression levels of genes related to focal adhesion and extracellular matrix (ECM)-receptors were significantly higher in NCA endometrium than in CA endometrium. The level of pro-inflammatory cytokines accumulated in the CA endometrium, and high abundance of integrin-β and THBS1 were localized in the luminal epithelium of the NCA endometrium, but not in the CA endometrium.ConclusionsOur study reveals differences in gene expression between the CA and NCA endometrium at mid-gestation of rabbit, and suggests implications for endometrial physiological function. The CA endometrium showed relative low-level gene expression compared to the NCA endometrium, while the NCA endometrium performed physiological functions related to focal adhesion and ECM-receptor interaction.

试验旨在研究饲粮中添加富马酸亚铁对断奶肉兔生产性能和肉品质的影响.选择600只体重相近的28日龄断奶新西兰兔,随机分为5组,每组12个重复,每个重复10只,公母各半.对照组基础饲粮不添加铁,试验组分别添加100 mg/kg硫酸亚铁和25、50、100 mg/kg富马酸亚铁.预试期7 d,正试期42 d.结果表明:与对照组相比,25 mg/kg富马酸亚铁提高了肉兔日增重(P<0.05),降低了耗料增重比(P<0.05),但与100 mg/kg硫酸亚铁组及50、100 mg/kg富马酸亚铁组差异不显著;各试验组胴体重和屠宰率高于对照组(P<0.05),但试验组间差异不显著;25 mg/kg富马酸亚铁组粪便、肝脏和肾脏中铁含量均低于100 mg/kg硫酸亚铁组(P<0.05),心脏和背肌中铁含量与各试验组差异不显著.由此可见,富马酸亚铁可提高肉兔日增重,降低耗料增重比,粪便、肝脏和肾脏中残留铁显著低于硫酸亚铁,可以显著改善肉品质、降低环境污染和节约矿物质资源,本试验条件下富马酸亚铁的适宜添加量为25 mg/kg.