Objective To observe the effects of Xuebijing injection on nuclear factor-kappa B activation of PMN and the prognosis of cardiovascular injury. Methods 70 cases of acute organophosphate poisoning complicated with cardiovascular injury were divided into the positive control group(35 cases)and the test group(35 cases) at random.The enzyme labeled immunohistochemical method was used to determine the NF-κB activation degree.Changes of myocardial enzyme were also observed.Results ① Death rate of the test group was lower than that of the control group(P0.05).② The NF-κB activation degree of the control group was higher than that of the test group(P0.05).③ Xuebijing injection suppressed the activation of NF-κB on dosage(P0.05).④ The degree of myocardial enzyme recovery of the test group was superior to that of the control group and was dose-dependent on Xuebijing injection(P0.05).Conclusion Xuebijing injection in combination with routine therapies has obvious efficiency on increasing the success rate of acute organophosphorus pesticide poisoning patients complicated with cardiovascular injury.

Objective To observe the effects of Shengmai Injection on NF-κB activation of the neutrophile granulocyte,serum TNF-a level and the prognosis of resuscitation on patients who had recovered from cardiac arrest.Methods The enzyme labeled immunohistochemical method was used to determine the NF-κB activation degree.Radio-immunity(RI) was used to determine the blood serum level of TNF-a.Changes of vital signs and laboratory examination indexes were also observed.Results ①The time,degree of vital signs recovery of the test group were superior to those of the control group,and the differences were statistically significant(P0.05).② The degree that NF-κB moved into the nucleolus and the TNFa level of the control group were higher than those of the test group,and the differences were statistically significant(P0.01).③Shengmai Injection suppressed the activation of NF-κB and the blood serum level of TNF-a on dosage(P0.01).④ The NF-κB activation degree and the TNF-a level were negatively correlated with the recovery of vital signs.The better the vital signs recovered,the lower were the NF-KB activation and the TNF-a level.Conclusion Shengmai Injection plus routine therapeutics have obvious therapeutic efficiency in protecting heart function,supporting good circulation state,and increasing the success rate of CPR possibly by suppressing the NF-κB signaling pathway and reducing NF-κB controled inflammation factors in a dose-dependent manner.

胆碱能受体阻滞剂是作用于胆碱能受体(ChR)的一类药物,可阻滞乙酰胆碱(ACh)和ChR结合,使ACh不能发挥作用,表现为胆碱能神经功能被阻滞的种种效应[1].

有机磷农药中毒是临床上常见的中毒类型,近年来发生率居高不下,中毒年龄趋向年轻化,以女性患者为主.各地医院的治疗方案不尽相同.本研究主要讨论早期大剂量静注肟类胆碱酯酶复能剂-氯磷定[1]和常规静注经验剂量氯磷定两种方法治疗急性有机磷中毒(AOPP).从胆碱酯酶(CHE)的恢复情况,病人临床症状的改善以及有无中间综合征(IMS),迟发性神经症状等方面比较两种方法的优劣.