HIMACは，がんの重イオン治療のために建設された医療専用加速器である。しかし，放射線医学総合研究所は研究所であることから，医療に必要な性能を確保すると同時に，高エネルギー重イオンに関連する基礎研究にも対応できる性能を持った装置に作られている。その性能は，陽子から中重核の粒子を高エネルギーに加速し，将来の重イオン研究拡大に向けたアップグレードを視野に置いた，フレキシビリティーに富んだものである。

The relative electron density resolution was discussed by the Wiener spectrum in the heavy ion CT image. The two-dimensional (2D) Wiener spectrum in the CT image was obtained from the one-dimensional (1D) Wiener spectrum of the measured residual range distribution of the water phantom for a single projection angle, and the relative electron density resolution in the CT image was calculated from the 2D Wiener spectrum. To examine the usefulness of this method, the relative electron density resolution was also estimated by other two methods; the calculation using the Wiener spectrum of the reconstructed image of the water phantom, and the estimation by the reconstructed image of the electron density resolution phantom. The result of the first method was similar to those of the other two methods. Therefore, it is useful to estimate the relative electron density resolution by the 1D Wiener spectrum of the measured residual range distribution of the water phantom for a single projection angle.

The heavy ion CT system is proposed which is based on measurement of the residual range distribution by a fluoroscopy detector consisting of an intensifying screen and a CCD video camera. To investigate the fundamental performance of the proposed system, the spatial and density resolutions of the CT image were evaluated. The heavy ion beam 12C accelerated up to 400 MeV/u by HIMAC was used in this study. A series of projection images of two types of phantoms (PMMA pipes with several sizes and various kinds of rods with different electron densities) were experimentally taken for five values of range shifter thickness at each projection angle. From these images, the residual range distribution was obtained and used to reconstruct CT images of the relative stopping power which were obtained by the filtered back projection method with the Shepp-Logan filter after noise reduction processing by the median filter. As a result, the spatial resolution was found to be less than 2 mm and the relative density resolution around the density of water was less than 0.07.

The doses for the overexposed patients were estimated by the measurement result of specific activity of 24Na in blood. The present method is almost based on documents of the International Atomic Energy Agency (IAEA) and the Oak Ridge National Laboratory. The neutron energy spectrum obtained using the ANISN code (Multigroup One-Dimensional Discrete Ordinates Transport Code System with Anisotropic Scattering) was assumed. The values in ICRP Publication 74 were applied for the doses in each organ per unit neutron fluence. Gamma-ray dose was indirectly estimated based on (a) the result of environmental monitoring around the accident site and (b) a graph in IAEA manual, which gives the kerma ratio of neutrons and gamma-rays as a function of the critical volume or the atomic ratio of hydrogen to 235U. The estimated neutron doses were 5.4 Gy for patient A. 2.9 Gy for patient B and 0.81 Gy for patient C. The estimated gamma-ray doses were 8.5 or 13 Gy for patient A, 4.5 or 6.9 Gy for patient B, and 1.3 or 2.0 Gy for patient C.

Purpose: The irradiation system and biophysical characteristic carbon beams are examined regarding radiation therapy.Methods and Materials: An irradiation system was developed for heavy-ion radiotherapy. Wobbler magnets and a scatterer were used for flattening the radiation field. A patient-positioning system using X ray and image intensifiers was also installed in the irradiation system. The depth-dose distributions of the carbon beams were modified to make a spread-out Bragg peak, which was designed based on the biophysical characteristics of monoenergetic beams. A dosimetry system for heavy-ion radiotherapy was established to deliver heavy-ion doses safely to the patients according to the treatment planning. A carbon beam of 80 keV/mu m in the spread-out Bragg peak was found to be equivalent in biological responses to the neutron beam that is produced at cyclotron facility in National Institute Radiological Sciences (NIRS) by bombarding 30-MeV deuteron beam on beryllium target. The fractionation schedule of the NIRS neutron therapy was adapted for the first clinical trials using carbon beams.Results: Carbon beams, 290, 350, and 400 MeV/u, were used for a clinical trial from June of 1994. Over 300 patients have already been treated by this irradiation system by the end of 1997. (C) 1999 Elsevier Science Inc.

A three-dimensional irradiation system using a broad beam has been installed for heavy-ion cancer therapy at the Heavy Ion Medical Accelerator in Chiba (HIMAC) facility. Only the target region is irradiated at the 100% dose level; the dose level at other parts of irradiated tissues is less, using a range shifter, a multileaf collimator and a compensator. The devices are the same as those used in two-dimensional irradiation, except that the setting values of the devices can be dynamically changed during the treatment. The thickness of the absorber and the aperture of the multileaf collimator are dynamically controlled during irradiation, so that the Bragg peak is swept in the depth direction and the Bragg peak outside of the target volume is blocked by the multileaf collimator. The performance of this system was checked by irradiation of a phantom using a 290 MeV/nucleon carbon beam. The dose distribution realized by this three-dimensional irradiation agreed satisfactorily with the planned one.

To draw the maximum advantage from accelerated heavy ions requires a treatment plan that enables us to concentrate sufficient dose to a target region and to spare surrounding critical organs. Powerful computer support is needed to implement such a plan because it is an iterative process in which we need quick changes of displayed images including threedimensional (3D) models, and high-speed computation of 3D dose distributions . Our treatment planning system, which is called HIPLAN (Heavy Ion Plan), is constructed on modern graphical workstations running UNIX and X Window System . It implements functions required for 3D treatment planning and enables us to determine the parameters to control the irradiation system of HIMAC. In this paper we describe the software specifications , system architecture, hardware platforms and operation examples of the present version of HIPLAN, and discuss future prospects.