The antiviral activity of 2-substituted and 2,6-disubstituted quinoline-4-carboxylic acids and their derivatives has been studied against orthopoxviruses on Vero and MK-2 cell cultures. High activity has been found for 2-(1,1′-biphenyl-4-yl)quinoline-4-carboxylic acid.

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Изучена противовирусная активность некоторых 2- и 2,6-дизамещенных 4-хинолинкарбоновых кислот и их производных в отношении ортопоксвирусов на культуре клеток Vero и MK-2. Высокая противовирусная активность выявлена для 2-(1,1'-бифенил-4-ил)-4-хинолинкарбоновой кислоты.

ChemInformVolume 42, Issue 37 Heterocyclic Compounds ChemInform Abstract: Unusual Bromination of Methyl 8-Allyl-2-methyl-1,2,3,4-tetrahydroquinoline-4-carboxylate (IV). Yu. A. Zhuravleva, Yu. A. Zhuravleva Samara State Univ., Samara 443010, RussiaSearch for more papers by this authorA. V. Zimichev, A. V. Zimichev Samara State Univ., Samara 443010, RussiaSearch for more papers by this authorM. N. Zemtsova, M. N. Zemtsova Samara State Univ., Samara 443010, RussiaSearch for more papers by this authorYu. N. Klimochkin, Yu. N. Klimochkin Samara State Univ., Samara 443010, RussiaSearch for more papers by this author Yu. A. Zhuravleva, Yu. A. Zhuravleva Samara State Univ., Samara 443010, RussiaSearch for more papers by this authorA. V. Zimichev, A. V. Zimichev Samara State Univ., Samara 443010, RussiaSearch for more papers by this authorM. N. Zemtsova, M. N. Zemtsova Samara State Univ., Samara 443010, RussiaSearch for more papers by this authorYu. N. Klimochkin, Yu. N. Klimochkin Samara State Univ., Samara 443010, RussiaSearch for more papers by this author First published: 18 August 2011 https://doi.org/10.1002/chin.201137148Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume42, Issue37September 13, 2011 RelatedInformation

Приведены результаты антимикобактериальной активности соединений ряда 2-арил(гетерил)-4-хинолинкарбоновых кислот. Найдены перспективные препараты против M. tuberculosis H37 Rv.

In the title mol-ecule, C(14)H(15)NO(3), the six-membered heterocyclic ring exhibits an envelope conformation. In the crystal, C-H⋯π inter-actions link the mol-ecules into centrosymmetric dimers, and weak inter-molecular C-H⋯O hydrogen bonds link these dimers into columns propagated along [100].

We present an evaluation of the antimycobacterial activity of a series of 2-aryl(heteryl)-4-quinolinecarboxylic acids. Compounds with potential value against Mycobacterium tuberculosis H37Rv were found.

The compound C 15 H 18 NO 2 Br was synthesized and characterized by X-ray diffraction. The crystals belong to the monoclinic system, sp. gr. P 2 1 / n , a = 8.913(2) Å, b = 23.637(6) Å, c = 13.892(3) Å, β = 90.31(2)°, Z = 8, V = 2926.8(12) Å 3 , ρ calc = 1.472 g/cm 3 . The bond lengths and bond angles in two molecules are equal within an experimental error and are typical of this class of compounds. The conformational differences of the saturated heterocyclic and methoxycarbonyl fragments of the molecules result in the presence of two crystallographically independent molecules in the crystal structure.

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2-R-4-R′-quinolines, where R is a thienyl-2,2,2′-bithienyl-5-yl, or 1,1′-biphenyl-4-yl group and R′ is an azidocarbonyl- or carboethoxyamino group, were found to have antimicrobial activity against the diphtheria bacillus and Staphylococcus P-209.