192 patients with acromegaly were examined. Their reproductive disorders were found to be a result of the suppressed synthesis of gonadotropin hormones due to the tumor compression of the adenohypophysis, due to blocking effect of hyperprolactinemia on the gonadotropic function or as a result of the direct impact of insulin-like growth factor-I stimulating hyperplastic processes in target organs, such as ovaries, the glandular epithelium of the breast and myometrium. The structure of reproductive disorders in patients with acromegaly includes menstrual disturbances, infertility, early menopause and hyperplastic processes. Close management of the reproductive system, early detection of neoplasia and correction of the existing disorders are highly required during therapy for acromegaly.

BackgroundThe aim is to investigate the influence of the benign hyperplastic process of endometrium over the uterine blood flow resistance.MethodThe transvaginal ultrasound with Color Flow Mapping and Dopplerometry was used for examination of 90 patients (28 with hyperplasia, 30 with glandular and 32 with fibroid polyps) and of 30 healthy women (in 1st phase of menstrual cycle). Arteries visualization rate and values of Doppler indices for myometrial (the main uterine, arcuate, radial) and endometrial (basal, spiral) vessels were assessed.ResultsThe main uterine and arcuate arteries were visualized in all cases. As crossing from feeding uterine vessels deeper to the endometrium, the tendency of reduction possibility of its visualization was marked. That probably corresponds with reduction of arteries size. The resistance indices were: Healthy Hyperplasia Glandular polyps Fibroid polyps Uterine arteries 0.88 0.81 0.83 0.83 Arcuate arteries 0.78 0.75 0.73 0.73 Radial arteries 0.71 0.68 0.67 0.63 Basal arteries 0.57 0.52 0.51 0.52 Spiral arteries – 0.53 0.50 – Polyp arteries 0.58 0.49 ConclusionBenign hyperplastic process of endometrium was accompanied by lowering Doppler indices values in all arteries in comparison with normal condition, that show intensification of the blood supply.

BackgroundThe purpose of study was to find out changes of Doppler parameters in all uterine arteries during antirecurrent hormonal courses and to define their role in prediction of outcomes.Method53 patients receiving hormonal therapy (Norcolut, Provera, Danazol) after D & C were undergone 6 months monitoring by transvaginal ultrasound with Color Flow Mapping and Doppler assessment of the main uterine, arcuate, radial and basal arteries. The mean values of resistance indices (RI) were calculated after retrospective division into groups with effective (n = 41) and effectless (n = 12) treatment. Investigated RI data were used for statistical creation of prognostic upper and lower cut‐off levels (for P < 0.05).ResultsThe resistance indices were: Healthy Effective treatment Effectless treatment Cut‐off intervals for P < 0.05 Uterine arteries 0.88 0.86 0.83 0.83–0.87 Arcuate arteries 0.78 0.74 0.72 0.65–0.80 Radial arteries 0.71 0.73* 0.65* 0.60–0.75 Basal arteries 0.57 0.62 0.57 0.48–0.68 – p < 0.10 ConclusionFor predicting effectiveness of hormonal treatment after two months from its beginning Doppler measurements should be carried out in Radial Arteries and RI must exceed 0.75.