目的：本文主要通过研究瑞舒伐他汀钙对颈动脉粥样硬化的治疗效果，分析其有效性和安全性。方法：选取笔者所在医院2011年1月-2013年1月接受治疗的100例颈动脉粥样硬化患者，将患者随机分为研究组和对照组，每组患者50例，其中研究组患者服用20 mg/次瑞舒伐他汀钙，而对照组患者则服用10 mg/次的瑞舒伐他汀钙，每晚服用1次，连服6个月为一个疗程。通过超声检查患者颈动脉并进行血脂的测定，判断两组患者疗效。结果：对照两组的颈动脉CIMT(内-中膜厚度)、颈AS斑块面积、TC(血清总胆固醇)、TG(甘油三酯)、LDL-C(低密脂蛋白胆固醇)、HDL-C(高密脂蛋白胆固醇)等指标，治疗后与治疗前比较，CIMT、AS斑块面积明显减少(P<0.01)，TC、TG和LDL-C水平降低显著(P<0.01)， HDL-C则显著升高，差异有统计学意义(P<0.01)。其中研究组和对照组比较，上述指标的改善更加明显。研究组无明显不良反应。结论：使用瑞舒伐他汀钙开展强化降脂，可以有效降低患者的CIMT、TC和LDL-C的水平，同时，升高HDL-C的水平，无其他并发症，疗效较好且安全性较高。

Objective To observe the effects of Guizhi Fuling Capsule in the treatment of patients with carotid atherosclerosis (CAS). Methods One hundred and thirty-eight CAS patients with carotid intima-media thickening and / or plaque formation confirmed by ultrasonic from March 2011 to June 2012 were involved in this study. The patients were randomly divided into three groups: the treatment group (50 cases, treated with Guizhi Fuling Capsule 3 times daily, 4 granules for each time), the western medicine control group (the control group 1, 46 cases, treated with aspirin enteric-coated tablets 100 mg, once daily), and the Chinese medicine control group (the control group 2, 42 cases, treated with compound Danshen Dripping Pill 3 times daily, 10 pills for each time). All groups were treated for 6 months. The concentration of serum lipids, plasma endothelin (ET-1) and nitric oxide (NO), the changes of Platelet CD41, CD63, CD62P, the changes of bilateral carotid artery intima-media thickness (IMT), plaque morphology before treatment and 6 months after treatment were detected respectively. Results ① No significant difference was found in serum lipids, ET, NO concentration between the three groups before treatment and after treatment (P>0.05). ② CD41, CD63, CD62P levels in the treatment group after treatment were significantly lower than those before treatment (P<0.05), while no significant difference were found in both control group 1 and control group 2 (P>0.05). ③ IMT, unstable plaque and plaque area in the treatment group were significantly better than those in the control group 1 and control group 2 (P<0.05). ④No serious adverse reactions were found in the treatment group group. Conclusion Guizhi Fuling Capsule could reduce the number of unstable plaque in the carotid artery and its area, decrease IMT, and improve endothelial function and anti-platelet activity in patients with CAS.