e15616 Background: Following neoadjuvant chemoradiotherapy (nCRT), total mesorectal excision surgery used to be the standard therapy for locally advanced rectal cancer (LARC). However, the radical surgery is associated with high complication rates and impairs patients' quality of life, especially for non-sphincter preservation procedures. For the past two decades, nCRT followed by organ preservation strategies like watch-and-wait (W&W) or local resection offers an alternative for patients being clinically evaluated with complete response or near complete response, however the oncological outcomes of these approaches require further exploration. Methods: We prospectively collected data on 80 patients with T3-4N0M0 or TanyN+M0 mid-low rectal cancer who achieved cCR or near-cCR after nCRT from May 2017 to September 2021 at 5 tertiary centers in China. Patients were divided into the TEM group (group A) or the radical surgery group (group B). Clinicopathological features, operative outcomes, oncological and functional results were analyzed. Results: A total of 76 cases were analyzed, with 38 in each group. Baseline characteristics were comparable between the two groups. Postoperative histology revealed 22 ypT0Nx(57.9%), 5 ypT1Nx(13.2%), 10 ypT2Nx (26.3%), 1 ypT3Nx(2.6%) in group A, and 18 ypT0N0 (47.4%), 5 ypT1N0 (13.2%), 11 ypT2-3N0 (28.9%), 1 ypT0N1 (2.6%), 3 ypT2-3N1 (7.9%) in group B. After a median follow-up of 61 months, 2 patients (5.26%) in group A experienced local recurrence, while none in group B. 8 patients (21.05%) in group A developed distant metastases compared to 5 (13.16%) in group B. There was no statistically significant difference between two groups in 5-year disease-free survival(P = 0.320), or 5-year overall survival (P = 0.425). Patients in group A had significantly faster postoperative recovery and a superior quality of life evaluated by the Wexner and LARS scores compared to group B. Conclusions: For cCR and near-cCR LARC patients after nCRT, organ preservation with TEM may serve as a staging method to evaluate local tumor persisrence. And it provides an alternative therapy for carefully selected patients who have needs to preserve sphincteric function or can’t tolerate radical resection, without significantly compensate long-term oncological outcomes. This strategy could relatively safely enable sphincteric function preservation for these patients with faster postoperative recovery and better quality of life. Clinical trial information: NCT03042000 .

IntroductionThe mid-transverse colon cancer is relatively uncommon in all colon cancers and the optimal surgical approach of mid-transverse colon cancer remains debatable.Aim and ObjectivesOur study aimed to depict the techniques and outcomes of laparoscopic transverse colectomy in one single clinical center and compare this surgical approach to traditional laparoscopic right hemicolectomy and laparoscopic left hemicolectomy.MethodThis was a retrospective cohort study of patients with mid-transverse colon cancer in one single clinical center from February 2012 to October 2020. The enrolled patients were divided into two groups undergoing laparoscopic transverse colectomy and laparoscopic right/left hemicolectomy, respectively. The intraoperative, postoperative complications, oncological outcomes and functional outcomes were compared between the two groups. The primary endpoint was disease free survival (DFS).ResultsThe study enrolled 70 patients with 40 patients undergoing laparoscopic transverse colectomy and 30 patients undergoing laparoscopic hemicolectomy. The intraoperative accidental hemorrhage and multiple organ resection occurred similarly in the two groups. In transverse colectomy, caudal-to-cephalic approach was likely to harvest more lymph nodes although require more operation time than cephalic-to-caudal approach (23.1 ± 14.3 vs. 13.4 ± 5.4 lymph nodes, P = 0.004; 184.3 ± 37.1 min vs. 146.3 ± 44.4 min, P = 0.012). The laparoscopic transverse colectomy was marginally associated with lower incidence of overall postoperative complications and shorter postoperative hospital stay although without statistical significance (8(20.0%) vs. 12(40.0%), P = 0.067; 7(5–12) vs. 7(5–18), P = 0.060). The 3-year DFS showed no significant difference (3-year DFS 89.7% in transverse colectomy vs. 89.9% in hemicolectomy, P = 0.688) between the two groups. The alternating consistency of defecation occurred significantly less after laparoscopic transverse colectomy than laparoscopic hemicolectomy (15(51.7%) vs. 20(80.0%), P = 0.030).ConclusionThe laparoscopic transverse colectomy is technically feasible with satisfactory oncological and functional outcomes for mid-transverse colon cancer. Performing the caudal-to-cephalic approach might be more advantageous in lymphadenectomy.

目的 通过整理北京协和医院结肠癌专病数据库建立以来结肠癌患者的临床资料,展示条目信息缺失情况及随访率数据,以期为单中心数据库的建立提供借鉴.方法 收集北京协和医院结肠癌专病数据库中 2016 年 1 月 5 日至2022 年5 月11 日期间行手术治疗结肠癌患者的临床资料,包括基本信息、原发灶特征、手术与病理信息及术后并发症等33 个条目,计算各条目缺失率和患者随访率.结果 共入选符合纳入和排除标准的 1682 例结肠癌患者.其中男性981 例,女性701 例;平均年龄(62.75±11.97)岁;术后并发症发生率为15.6％(263/1682).该数据库包含的条目信息中,患者性别、年龄、民族等基本信息及病理分期信息均登记完全无缺失;而病变部位(12.2％)、免疫组化错配修复状态(8.0％)缺失率相对较高.33 个条目的缺失率分布于 0～12.2％,其中缺失率＜1％的条目占比 81.8％(27/33),缺失率＜5％的条目占比93.9％(31/33).随访率方面,完全失访的患者仅占比 1.7％,即具备随访信息患者的比例为98.3％;2020 年7 月2 日前入组患者(由于数据库迁移的原因,该日期后入组的患者不具有统一格式的定期随访信息)的第1、2、3、4、5 年随访率分别为 55.02％、70.96％、72.02％、65.42％、70.91％,2 年完全随访率为 19.5％.结论北京协和医院结肠癌专病数据库条目缺失率较低,几乎所有患者均具有随访信息,整体数据质量较高,具有一定参考价值,但连续随访率仍存在较大的提升空间.

Schwannoma is a benign tumor of the nerve sheath originating from Schwann cells. The tumor rarely occurs in the sciatic nerve. The patient in the present case report was a 58-year-old woman presenting with pain in the right hip and leg, as well as numbness of the right lower limb. Magnetic resonance imaging revealed a solid tumor of 2.9 cm in diameter in the right pelvic space. The mass was considered to be a neurogenic tumor originating from the right sciatic nerve. Total laparoscopic surgery was performed to safely separate the tumor from the surrounding tissues, with preservation of the right sciatic nerve. The pathological result suggested a schwannoma. The patient recovered well with a transient numbness in the right heel. The laparoscopic approach used for this intrapelvic schwannoma of the sciatic nerve was safe and feasible, with the advantages of a magnified surgical field and small skin incision. However, the specific surgical approach should be based on the detailed condition of each patient and the experience of the surgeon with regard to laparoscopic surgery on benign presacral tumors and rectal tumors.

Background We aimed to analyze the benefit of adjuvant chemotherapy in high-risk stage II colon cancer patients and the impact of high-risk factors on the prognostic effect of adjuvant chemotherapy.Methods This study is a multi-center, retrospective study, A total of 931 patients with stage II colon cancer who underwent curative surgery in 8 tertiary hospitals in China between 2016 and 2017 were enrolled in the study. Cox proportional hazard model was used to assess the risk factors of disease-free survival (DFS) and overall survival (OS) and to test the multiplicative interaction of pathological factors and adjuvant chemotherapy (ACT). The additive interaction was presented using the relative excess risk due to interaction (RERI). The Subpopulation Treatment Effect Pattern Plot (STEPP) was utilized to assess the interaction of continuous variables on the ACT effect.Results A total of 931 stage II colon cancer patients were enrolled in this study, the median age was 63 years old (interquartile range: 54-72 years) and 565 (60.7%) patients were male. Younger patients (median age, 58 years vs 65 years; P < 0.001) and patients with the following high-risk features, such as T4 tumors (30.8% vs 7.8%; P < 0.001), grade 3 lesions (36.0% vs 22.7%; P < 0.001), lymphovascular invasion (22.1% vs 6.8%; P < 0.001) and perineural invasion (19.4% vs 13.6%; P = 0.031) were more likely to receive ACT. Patients with perineural invasion showed a worse OS and marginally worse DFS (hazardous ratio [HR] 2.166, 95% confidence interval [CI] 1.282-3.660, P = 0.004; HR 1.583, 95% CI 0.985-2.545, P = 0.058, respectively). Computing the interaction on a multiplicative and additive scale revealed that there was a significant interaction between PNI and ACT in terms of DFS (HR for multiplicative interaction 0.196, p = 0.038; RERI, -1.996; 95%CI, -3.600 to -0.392) and OS (HR for multiplicative interaction 0.112, p = 0.042; RERI, -2.842; 95%CI, -4.959 to -0.725).Conclusions Perineural invasion had prognostic value, and it could also influence the effect of ACT after curative surgery. However, other high-risk features showed no implication of efficacy for ACT in our study.

Abstract Purpose: Our study was aimed to depict and summarize the technique, short and long term outcomes of laparoscopic transverse colectomy in one single clinical center and compare with laparoscopic hemicolectomy.Methods: This was a retrospective cohort study of patients with mid-transverse colon cancer in one single clinical center from February 2012 to October 2020. The enrolled patients were divided into two groups undergoing laparoscopic transverse colectomy and laparoscopic hemicolectomy, respectively. The intraoperative, postoperative complications, oncological outcomes and functional outcomes were compared between the two groups. The primary endpoint was disease free survival (DFS).Results: The study enrolled 70 patients with 40 patients undergoing laparoscopic transverse colectomy and 30 patients undergoing hemicolectomy. The intraoperative accidental hemorrhage and multiple organ resection occurred similarly in the two groups. In transverse colectomy, caudal-to-cephalic approach was likely to harvest more lymph nodes although require more operation time than cephalic-to-caudal approach (23.1(14.3) versus 13.4(5.4) lymph nodes, P=0.004; 184.3(37.1)min versus 146.3(44.4)min, P=0.012). The laparoscopic transverse colectomy was marginally associated with lower incidence of overall postoperative complications and shorter postoperative hospital stay although without statistical significance (8(20.0%) versus 12(40.0%), P=0.067; 7(5-12) VS 7(5-18), P=0.060). The 3-year DFS showed no significant difference (3-year DFS 89.7% in transverse colectomy versus 89.9% in hemicolectomy, P=0.688) between the two groups. The alternating consistency of defecation occurred significantly less after transverse colectomy (15(51.7%) VS 20(80.0%), P=0.030). Conclusions: The laparoscopic transverse colectomy is technically, oncologically and functionally feasible for mid-transverse colon cancer. Performing the caudal-to-cephalic approach might be more advantageous in lymphadenectomy.

PURPOSE:We investigated the value of circulating tumor DNA (ctDNA) in predicting tumor response to neoadjuvant chemoradiotherapy (nCRT), monitoring tumor burden, and prognosing survival in patients with locally advanced rectal cancer (LARC).EXPERIMENTAL DESIGN:This prospective multicenter trial recruited 106 patients with LARC for treatment with nCRT followed by surgery. Serial ctDNAs were analyzed by next-generation sequencing at four timepoints: at baseline, during nCRT, presurgery, and postsurgery.RESULTS:In total, 1,098 mutations were identified in tumor tissues of the 104 patients being analyzed (median, seven mutations/patient). ctDNA was detected in 75%, 15.6%, 10.5%, and 6.7% of cases at the four timepoints, respectively. None of the 29 patients with pathologic complete response (ypCR) had preoperative ctDNA detected. The preoperative ctDNA-positive rate was significantly lower in the well-responded patients with pathologic tumor regression grade of ypCAP 0-1 than ypCAP 2-3 group (P < 0.001), lower in ypCR than non-ypCR group (P = 0.02), and lower in pathologic T stage (ypT) 0-2 than ypT 3-4 group (P = 0.002). With a median follow-up of 18.8 months, 13 patients (12.5%) experienced distant metastasis. ctDNA positivity at all four timepoints was associated with a shorter metastasis-free survival (MFS; P < 0.05). Multivariate analyses showed that the median variant allele frequency (VAF) of mutations in baseline ctDNA was a strong independent predictor of MFS (HR, 1.27; P < 0.001).CONCLUSIONS:We show that ctDNA is a real-time monitoring indicator that can accurately reflect the tumor burden. The median VAF of baseline ctDNA is a strong independent predictor of MFS.

目的 对比分析腹腔镜右半结肠切除术中行腹腔内与腹腔外吻合后近期并发症发生情况.方法 回顾性分析2017-01-01至2021-01-07北京协和医院基本外科结直肠专业组收治的294例行腹腔镜右半结肠切除术病人的临床资料,术中行腹腔内吻合86例(腹腔内吻合组),行腹腔外吻合208例(腹腔外吻合组).使用Cochran-Mantel-Haenszel检验排除分层因素的混杂作用后,分析吻合位置对腹腔感染、吻合口漏、手术切口感染等术后并发症的影响.结果 腹腔内吻合组和腹腔外吻合组在淋巴结清扫范围和吻合方式方面差异有统计学意义(P＜0.05),腹腔内吻合组行完整结肠系膜切除(CME)病人比例更高(59.5％vs.41.8％,P=0.007),且全部行侧侧吻合.两组获取淋巴结数目、术中出血量、手术时间方面差异均无统计学意义(P＞0.05).总体并发症发生率为28.9％(85/294),共115例次.将所有行侧侧吻合的病人(155例)纳入并发症分析,并经分层分析排除淋巴结清扫范围和吻合方式的可能混杂作用后,腹腔内吻合组手术切口感染的发生率高于腹腔外吻合组,差异有统计学意义[18例(20.9％) vs.3例(4.3％),P=0.012],而在腹腔感染(舍或不合吻合口漏)、吻合口漏、呼吸系统感染、术后肠梗阻、乳糜漏方面差异则无统计学意义(P＞0.05).结论 腹腔镜右半结肠切除术病人中行腹腔内吻合者可能更易发生手术切口感染,应谨慎选择行腹腔内吻合病例.

目的 分析术前外周血白细胞相关炎性指标对非转移性结肠癌病人预后的预测价值.方法 回顾性分析2016年1月至2017年9月北京协和医院基本外科结直肠专业组收治的554例行结肠癌根治术病人的临床病理资料.Kaplan-Meier法分析白细胞(WBC)计数、中性粒细胞百分比(NE％)和中性粒细胞与淋巴细胞比值(NLR)与病人生存预后的关系;通过多因素COX回归分析影响病人预后的因素.结果 WBC、NLR和NE％的最佳截断值分别为8.25×109/L、2.27和59.0％.单因素分析显示,病人术前癌胚抗原(CEA)、NE％和NLR值和术后病理N分期与总生存(OS)、无病生存(DFS)均有相关性;病人年龄、术前WBC仅与OS具有相关性.多因素分析显示,病人术后病理N分期(HR=2.634,95％CI 1.441～4.814,P=0.002)和NLR(HR=1.098,95％CI 1.028～1.173,P=0.005)是OS的独立危险因素;术后病理N分期(HR=2.512,95％CI 1.627～3.880,P＜0.001)和NLR(HR=1.101,95％CI 1.037 ～ 1.169,P=0.002)是DFS的独立危险因素;病人年龄≥65岁是OS (HR=1.042,95％ CI 1.013～1.072,P=0.005)的独立危险因素.结论 虽然术前外周血NLR升高的非转移性结肠癌病人预后较差,但NLR值对病人预后ROC曲线区分度较低,故不建议将术前外周血白细胞相关炎性指标作为非转移性结肠癌预后的标记物.

目的 以Clavien-Dindo分级系统为标准,探讨腹腔镜根治性左半结肠切除术后并发症的发生情况,并分析其危险因素.方法 回顾性分析2016年3月至2020年7月北京协和医院行腹腔镜根治性左半结肠切除术81例病人的临床资料,对Clavien-DindoⅠ级及以上病人进行单因素及多因素分析,对于严重并发症、腹腔感染、吻合口漏采取单因素分析.单因素分析采用 χ2检验、Fisher精确法或曼-惠特尼(M ann-Whitney)U检验,多因素分析采用Logistic回归模型.结果 根治性左半结肠切除术后发生率较高的并发症有肠梗阻(11.1％,9/81)、腹腔感染(7.4％,6/81)和吻合口漏(6.2％,5/81).较高的术前血尿素氮(BUN)水平[OR=1.905,95％CI(1.204,3.015),P=0.006]为术后Clavien-DindoⅠ级及以上并发症发生的独立预测因素.单因素分析显示术中出血量 ≥100 mL(P=0.037)、BUN水平(P=0.005)与严重并发症发生相关.结论 腹腔镜根治性左半结肠切除术后并发症发生谱以感染类并发症为主,较高的术前BU N水平为术后并发症发生的危险因素.

目的 探讨经肛门内镜显微手术(TEM)局部切除早期直肠癌后续治疗方式的选择.方法 回顾性分析北京协和医院于2013-2019年间收治的105例经TEM切除直肠癌病人资料,所有病人均在知情同意后接受TEM.结果 105例病人经术前检查[直肠腔内超声和(或)直肠MRI]评估为cT1期且除外淋巴结转移,经病理学活检报告为腺瘤局部癌变或者直肠腺癌,均通过TEM完成直肠癌的局部扩大切除.105例病人术后36例行补救性根治性手术,29例行补救性放化疗,40例仅随访观察.105病人术后接受平均40(12～69)个月随访.随访期间,13例(12.4％)局部复发,2例(1.9％)远处转移,3例(2.9％)死亡.单因素分析结果显示,T分期(P=0.003)、是否R0切除(P＜0.01)和术后处理策略(P=0.036)是复发及死亡预测因子.在多因素分析中,T分期(HR 7.36,95％CI1.82～29.85,P=0.005)、是否R0切除(HR 20.82,95％CI 2.71～159.64,P=0.003)及术后处理策略(HR 0.57,95％CI0.08～0.38,P=0.003)与复发及死亡密切相关.结论 TEM局部切除pT1期直肠癌安全、有效.而对于pT2期或未达R0切除直肠癌病人术后复发风险高,后续积极采取根治术或辅助放化疗的补救性治疗可提高病人预后.

PURPOSE:To compare the prevalence of stoma-related complications and stoma reversal perioperative complications of patients with low-lying rectal cancer who received preventative loop ileostomy and those who underwent loop transverse colostomy.METHODS:This retrospective single-center study analyzed the clinicopathologic and surgical data of 288 patients with pathologically proven primary rectal cancer who underwent anterior resection of rectal cancer with preventative loop ileostomy or loop transverse colostomy between January 2012 and July 2017 at the Department of General Surgery, Peking Union College Hospital. The patients were allocated to the ileostomy group (n=82) and the loop transverse colostomy group (n=206). To achieve comparability of the ileostomy group and the loop transverse colostomy group with regard to potential confounding variables, a propensity score-matching method was used to match patients from each group in a 1:2 ratio. Determinants of stoma-related complications were analyzed by multivariate logistic regression analysis.RESULTS:The propensity score-matched loop ileostomy group (n=66) and the loop transverse colostomy group (n=111) were comparable in patient demographic and baseline characteristics. Forty-nine (74.3%) patients in the loop ileostomy group experienced stoma-related complications vs 48.7% in the loop transverse colostomy group (p<0.001). Irritant dermatitis was the most frequent complication in both groups. The loop ileostomy group had a significantly higher rate (24.24%) of stoma reversal perioperative complications than the loop transverse colostomy group (9.01%, p=0.008). Multivariate logistic regression analysis showed that ileostomy vs loop transverse colostomy was a significant independent risk for stoma-related complications (Odds ratio/OR 3.495; 95%CI 1.741, 7.018; p<0.001) and stoma reversal perioperative complications (OR 2.124; 95%CI 1.010, 4.512; p< 0.05).CONCLUSION:This study has demonstrated that loop transverse colostomy is associated with significantly lower rates of stoma-related complications and stoma reversal perioperative complications compared to loop transverse colostomy. Prospective controlled studies with a larger patient population are warranted to examine the efficacy and safety of loop ileostomy and loop transverse colostomy.

Objective To summarize and analyze our experiences uponperforming laparoscopic resection ofpresacral cysts,at the aim of generalizing the minimally invasive surgery in the treatment of this disease.Methods The clinical data of 33 patients with presacral cysts treated by laparoscopy in Peking Union Medical College Hospital of Chinese Academy of Medical Sciences from November 2012 to June 2017 were retrospectively analyzed.The operation time, the incidence of intraoperative and postoperative complications and the length of hospital stay were counted.Results Tumor excision was completed according to the plan without conversion to open surgery.The average operation time was ( 124.4 ± 63.0) minutes.There were 1 case of rectal injury and 1 case of presacral venous plexus hemorrhage.The complications were 6%.Postoperative rectal leakage occurred in 2 cases ( 6%).The average hospitalization time after operation was ( 6.7 ± 4.3) days.Of 33 cases, 2 cases were lost.One case had recurrence of presacral cyst one year after operation.Conclusion Laparoscopic resection of presacral cysts is technically feasible,and helps to improve intraoperative exposure,increase operating space and improve the resection rate of tumors.

Objective To assess the effect of preoperative enteral nutrition on malignant digestive tumors patients with nutritional risk.Methods A prospective clinical study was conducted on 73 malignant digestive tumors patients who were admitted in Department of General Surgery,Peking Union Medical College Hospital from January to June in 2015.Seventy-three patients were screened preoperatively by NRS 2002 and then divided into two groups:enteral nutrition group (n =31) and control group (n =42).Patients in enteral nutrition group were given oral or tube feeding elemental diet for 7-10 days before operation.Patients in control group ate normally.Both patients were given intravenous nutritional support postoperatively.The data of body weight,body mass index,blood total protein,albumin,pre-albumin and incidence of postoperative complications were compared on admission and before operation.Measured data were expressed as (x) ± s.The t-test was used to compare the indexes between groups.The paired t-test was used for comparison between admission and before surgery;the count data were expressed as frequency and percentage (％),comparison between groups use Chi-square test or Fisher's exact probability method.Results The nutritional status including body weight,body mass index,blood total protein,albumin and pre-albumin were significantly improved pre-operatively in enteral nutrition group (P ＜ 0.05),and postoperative complications including wound dehiscence,pneumonia and anatomotic leakage in enteral group were 9.68％,6.45％ and 3.23％ separately,which were less than that in control group (14.4％,11.9％ and 7.14％),however,the result was not significantly different (P ＞ 0.05).Conclusion Pre-operative enteral nutrition is safe and efficacy,which is helpful for malignant digestive tumors patients with nutritional risk.

目的 探索围手术期营养干预的加速康复外科(enhanced recovery after surgery,ERAS)流程对胃肠外科手术患者的安全性和有效性.方法 本研究为单中心前瞻性队列研究,连续纳入2015年12月至2018年4月期间在北京协和医院基本外科行胃肠手术的患者,在胃肠与营养代谢专业组接受手术治疗及ERAS管理的患者进入ERAS组,在其他专业组接受传统围手术期管理者进入对照组.ERAS组围绕术前营养评估、 口服或管饲营养补充、 术后早期肠内营养等措施,结合其他ERAS管理流程,主要包括微创手术、 全身麻醉或联合硬膜外阻滞等多模式镇痛、 术后镇痛以非甾体类抗炎药为主;对照组采用传统围手术期措施,主要包括开腹或微创手术、 全身麻醉、 术后镇痛应用阿片类镇痛药物等.主要结局指标为术后住院天数,次要结局指标包括住院总费用、 术后并发症发生率、 术后60 d内再入院率.结果 共纳入204例患者,ERAS组和对照组各102例.ERAS组术后住院天数较对照组明显缩短[(7.2±4.5)d比(9.8±4.8)d,P<0.001],住院总费用亦显著降低[(41125±18593)元比(51512±19453)元,P<0.001].两组术后Clavien-Dindo分级Ⅱ级及以上并发症发生率和术后60 d内再入院率无统计学差异(9.8％比13.7％,2.9％比2.0％,P均>0.05).结论 围手术期营养干预在胃肠外科中应用安全有效,有利于患者术后实现加速康复.

Objective To investigate the feasibility of segmental pylorus—reservation gastrectomy in patients with early gastric cancer. Method A retrospective cohort study on clinical data of 6 patients strictly met the criteria of early gastric cancer locating in the middle of the stomach undergoing laparoscopic segmental gastrectomy from January 2014 to April 2016 at Department of General Surgery, Peking Union Medical College Hospital was carried out. Preoperative clinical staging revealed T1N0M0 for all the cases. One case received endoscopic mucosa resection (EMR) first, and postoperative pathology showed moderate differentiated adenocarcinoma invading substratum of mucosa, so a complementary laparoscopic segmental gastrectomy was performed. Surgical procedure was laparoscopic segmental gastrectomy with D1 or D2 lymph node dissection. Vagus nerve was not reserved during lymph node dissection in lesser curvature side. Number of resected lymph node, postoperative complication and long-term gastric function were observed. Result Of 6 cases, 3 were male and 3 were female with age ranging from 55 to 59 years old. The distal resection margin was (4.6 ± 0.5) cm away from pylorus. The average number of resected lymph node was 18.3 ± 7.5 without metastasis. Follow-up time was 1 to 29 months for all the 6 cases and no relapse or metastasis was found during the follow-up. In 4 cases with follow-up beyond 1 year, 3 cases had slight distension in superior belly after meal and dyspepsia;another one case had vomiting nocturnal occasionally. Gastroscope examination one year after operation found food residue in all the cases. Images indicated the decrease of stomach size in all the cases. Two cases had esophagogastric reflux. All the patients had delayed gastric emptying symptoms after operations and were relieved within one year. Conclusions It is technically feasible to perform laparoscopic segmental gastrectomy in patients with early gastric cancer. Whether vagus nerve should be reserved requires further investigation.

Objective To evaluate the prognostic value of the log odds of positive lymph nodes (LODDS) in stage 3 colorectal cancer (CRC) patients who have undergone curative resection. Methods We performed a retrospective review of 175 stage 3 CRC patients who underwent curative resection in Peking Union Medical College Hospital from 2005 to 2012. Patients were categorized respectively according to the AJCC/UICC N grade,the metastatic lymph node ratio (LNR),and the ratio of their LODDS. The relationship between the N grade,LNR,LODDS,and overall survival (OS) rates were assessed.Results The five-year disease-free survival (DFS) was significantly different among stage 3 CRC patients in different N grade (Χ(2)=33.1,P=0.000),LNR (Χ(2)=14.3,P=0.001),and LODDS (Χ(2)=14.9,P=0.001). Univariate analysis showed that TNM stage (Χ(2)=27.0,P=0.000),cancerous node(Χ(2)=3.6,P=0.040),N grade (Χ(2)=33.1,P=0.000),LNR (Χ(2)=14.3,P=0.001),and LODDS (Χ(2)=30.4,P=0.000) were related to OS. Multivariate analysis indicated that TNM stage (HR:1.84,95%CI:1.59～6.29,P=0.001) and LODDS classification (HR:1.34,95%CI:1.01～1.80,P=0.047) were independent prognostic factors for OS in stage 3 CRC patients. Conclusion LODDS is a good prognostic indicator in stage 3 CRC patients who have undergone curative resection.

We report on a patient diagnosed with Peutz-Jeghers syndrome (PJS) with synchronous rectal cancer who was treated with laparoscopic restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA). PJS is an autosomal dominant syndrome characterized by multiple hamartomatous polyps in the gastrointestinal tract, mucocutaneous pigmentation, and increased risks of gastrointestinal and nongastrointestinal cancer. This report presents a patient with a 20-year history of intermittent bloody stool, mucocutaneous pigmentation and a family history of PJS, which together led to a diagnosis of PJS. Moreover, colonoscopy and biopsy revealed the presence of multiple serried giant pedunculated polyps and rectal adenocarcinoma. Currently, few options exist for the therapeutic management of PJS with synchronous rectal cancer. For this case, we adopted an unconventional surgical strategy and ultimately performed laparoscopic restorative proctocolectomy with IPAA. This procedure is widely considered to be the first-line treatment option for patients with ulcerative colitis or familial adenomatous polyposis. However, there are no previous reports of treating PJS patients with laparoscopic IPAA. Since the operation, the patient has experienced no further episodes of gastrointestinal bleeding and has demonstrated satisfactory bowel control. Laparoscopic restorative proctocolectomy with IPAA may be a safe and effective treatment for patients with PJS with synchronous rectal cancer.

OBJECTIVE:To investigate the feasibility of laparoscopic approach for totally mesocolic resection and D3 lymphadenectomy in right colectomy.METHODS:A retrospective study was conducted to analyze the operating time, blood loss, lymph node retrieval, postoperative complications and converting rate. The relationships of 3-year disease-free survival (DFS), 3-year overall survival (OS) to gender, age, American Society of Anesthesiologists (ASA) score, body mass index (BMI), T-staging, N-staging and TNM classification were also analyzed by Kaplan-Meier surviving curve and Log-rank test.RESULTS:A total of 111 patients were enrolled in present study. There were 50 male and 61 female patients. The average operating time was (168 ± 42) minutes, blood loss was (81 ± 63) ml, lymph node retrieval was (30 ± 12). The converting rate to open surgery was 1.8%. There was no death within 30 days after operation. The 3-year DFS and 3-year OS was 86.5% and 93.7% respectively. The short-term complications occurred in 17.1% of the patients, including diarrhea (7 cases), ileus (3 cases), urinary infection (3 cases), wound dehiscence (2 cases) and so on. With the T staging progress, DFS and OS in patients showed a gradual decline, but the difference did not reach statistical significance (P > 0.05). TNM classification had relation to DFS (χ(2) = 6.985, P = 0.030), while N-staging showed significant relations both to DFS and OS (χ(2) = 14.397, P = 0.001; χ(2) = 16.699, P = 0.000).CONCLUSION:Laparascopic approach to right hemicolectomy with complete mesocolic resection and D3 lymphadenectomy is safe and has satisfied oncological outcome.

Objective To assess the value of protective stoma in low anterior resection for rectal cancer prospectively.Methods One hundred patients with mid and low rectal cancer who undergone selective open low anterior resection in our hospital from October 2006 to October 2011,fitting inclusion criteria,were randomized into three groups.Group A(33 cases) received per-ascending colon ileostomy with a Foley's tube after colorectal anastomosis.Group B(35 cases) received loop transverse colostomy or terminal ileostomy.Group C(32 cases) received no protective stoma.The occurrence rate of anastomotic leakage and stoma-related complications were collected.Results Five patient developed anastomotic leakage in all 100 patients with a rate of 5.0%.The occurrence rate of anastomotic leakage in group A,B,C was 6.1%(2/33),5.7%(2/35) and 3.1%(1/32),respectively,and there was no statistic difference among three groups(P=0.838).The occurrence rate of anastomotic leakage in 68 patients with a protective stoma(group A and B) was 5.9 %(4/68),while it was 3.1 %(1/32) in 32 patients without protective stoma(group C),and there was no statistic difference between them(P=0.922).Four patients(in group A and B) with a protective stoma had slight symptoms,while one patient(in group C) without protective stoma had severe symptoms when anastomotic leakage occurred.Only two patients in group A temporally developed abdominal fistulae passing intestinal contents after the Foley's tube removed,and the fistulae healed soon by change of dressing.However,the occurrence rate of stoma complications and later stoma-closure complications in group B was high to 25.7%(9/35)and 22.9%(8/35).Conclusions A protective stoma can not reduce the incidence of anastomotic leakage after low anterior resection for rectal cancer,but can improve clinical manifestations after leakage.Traditionary protective transverse colostomy or terminal ileostomy has high incidence of stoma-related complications.Per-ascending colon tube ileostomy is an ideal alternative for patients with risk factors associated with anastomotic leakage.