Инциденталома в широком медицинском понимании является опухолью какого-либо органа, выявленной при радиологическом обследовании случайно (не по поводу болезни данного органа).

Carcinoid syndrome develops as a sequel of enhanced secretion of vasoactive substances from neuroendocrine tumours (NET). Somatostatinoma is an extremely rare variant of NET that manifests itself in cholelithiasis, steatorea, and diabetes mellitus. Somatostatinoma is usually diagnosed in adult subjects. Carcinoid syndrome is not a typical consequence of somatostatinoma. We present the first case report of somatostatinoma that was diagnosed in a child having carcinoid syndrome. The diagnosis was made difficult by the negative results of the search for biochemical markers of carcinoid syndrome and the small size of the primary tumour that could not be visualized by computed tomography. The immunohistochemical studies demonstrated secretion of somatostatin and calcitonin. The treatment of the child with somatostatin analogs proved inefficient which can be accounted for by the late diagnosis of the disease and the extensive metastatic process.

Carcinoid syndrome develops as a sequel of enhanced secretion of vasoactive substances from neuroendocrine tumours (NET). Somatostatinoma is an extremely rare variant of NET that manifests itself in cholelithiasis, steatorea, and diabetes mellitus. Somatostatinoma is usually diagnosed in adult subjects. Carcinoid syndrome is not a typical consequence of somatostatinoma. We present the first case report of somatostatinoma that was diagnosed in a child having carcinoid syndrome. The diagnosis was made difficult by the negative results of the search for biochemical markers of carcinoid syndrome and the small size of the primary tumour that could not be visualized by computed tomography. The immunohistochemical studies demonstrated secretion of somatostatin and calcitonin. The treatment of the child with somatostatin analogs proved inefficient which can be accounted for by the late diagnosis of the disease and the extensive metastatic process.

Адренокортикальный рак (АКР) редкое заболевание, до настоящего момента характеризующееся поздним сроком выявления и неблагоприятным лечебным прогнозом.

ACTH-ectopic hypercortisolism is one of the most соmplex variants of endocrine pathology presenting with v arious metabolic changes. Its early localization still represents a cornerstone of radical treatment of such patients. In this article w e discuss a clinical case of woman with ectopic secretion of ACTH by malignant lung carcinoid, which localization and therefore surgical treatment wаs possible only after three-year period of extensive diagnostic workup.

АКТГ-эктопированный гиперкортицизм является одним из наиболее тяжелых вариантов эндокринной патологии и проявляется множественными нарушениями обмена веществ. Его ранняя топическая диагностика остается до сих пор краеугольным камнем радикального лечения пациентов. Мы представляем клинический случай с эктопической секрецией АКТГ злокачественным карциноидом легкого, выявление которого и, следовательно, оперативное лечение, стало возможным только после трехлетнего периода интенсивных поисков источника заболевания

In plastic deformation of 30 steel by tension on the S = f(δ1/2) curves there are clearly recorded points of breaks corresponding to the initial (point A) and later (point D) stages of development of the destruction processes in deformation.