目的了解有血液学异常的HIV感染患者的血细胞形态特点。方法分析16例有血液学异常HIV感染患者的外周血、骨髓细胞学和骨髓病理学特点。结果患者外周血可表现1～3系血细胞减少,骨髓细胞增生活跃以上占68.8%,各系细胞增生与骨髓细胞增生情况不全一致,粒、红、巨核三系细胞都存在发育异常的表现,淋巴细胞、浆细胞比例增高。骨髓病理学检查:三系细胞比例和形态与细胞学检查结果接近,部分患者的骨髓出现纤维化。结论 HIV感染患者常出现血细胞减少,骨髓细胞常存在发育异常的表现,但需与骨髓增生异常综合征等相关疾病鉴别,避免漏诊和误诊。

OBJECTIVE To assess the value of searching for parasites and pathogenic bacteria in bone marrow examination of patients with FUO.METHODS The smears of bone marrow and the clinical data obtained from 160 patients with FUO were analyzed retrospectively.RESULTS Of the 160 patients with FUO,parasites and pathogenic bacteria were found in13 cases(8.1%),including 7 patients with penicilliosismarnefei(4.4%),2 with Leishmania(1.3%),and 4 with malarial parasite(2.5%).CONCLUSIONS Carefully searching for parasites and pathogenic bacteria in bone marrow play an important role in the diagnosis of patients with FUO.

Objective To 1earn bone marrow morphocytology in systemic lupus erythematosus(SLE) patients with peripheral cytopenia.Methods The smears of bone marrow aspirates obtained from 34 SLE patients who had bone marrow aspiration due to peripheral cytopenia (WBC<4×109/L, or Hb<100 g/L, or platelet count<100×109/L) were examined retrospectively.And the smears of the bone marrow aspirates obtained from 14 healthy controls,18 patients with MDS (refractory anemia), and 26 patients with idiopathic thrombocytopenic purpura (ITP) were inserted randomly among those obtained from the SLE patients.Results Of the 34 SLE patients, 24(70.6%) had dysplasias, including: erythroid cell multinuclearity (trinuclear or more) 10(29.4%), megaloblastoid changes 8(23.5%), pseudo Pelger-Hüet abnormalities 12(35.3%),separated nuclear megakaryocytes 8(23.5%), and micromegakaryocytes 10(29.4%).Conclusion This study found that bone marrow dysplasia can be observed in all lineage cells of SLE patients, We conclude that the bone marrow may be a target organ in SLE with cytopenia.

类风湿关节炎(RA)是一种致畸性的自身免疫性疾病,未经及时治疗可出现严重的关节畸形.早期诊断及早期治疗至关重要.现行的RA诊断标准只有免疫球蛋白M类风湿因子(IgM-RF)是实验室指标,且特异性不高,不利于早期诊断.我们应用德国欧蒙公司提供的第二代环瓜氨酸肽(CCP)抗原检测73例RA患者血清中的抗CCP抗体,并同时检测抗角蛋白抗体(AKA)、RF,以了解抗CCP抗体、AKA和RF在RA中的意义,探讨它们在RA诊断中的作用.

Objectives To simultaneously compare and evaluate the examinations of bone marrow smear and trephine biopsy in differential diagnosis and the therapeutical effect of patients with hematologic disease.Methods We study simultaneously bone marrow smear and trephine biopsy in 71 patients with pancytopenia and 34 patients with acute leukemia.BM smears are stained with Wright stain.BM biopsy material is processed and embedded in plastic,and sections((3 μm)) are made for examination.The sections are stained with HGF.Results The results showed that the degree of cellularity in bone marrow biopsy for cytologic morphology was higher than that for smear,but the misdiagnosis rate was lower than that in the smear.Conclusion Bone marrow aspiration and trephine biopsy are complementary techniques for diagnosis and evaluation of the therapeutical effect of patients with hematologic disease,especially of the patients with pancytopenia and acute leukemia after chemotherapy.

To simultaneously compare and evaluate the examinations of bone marrow smear and trephine biopsy in differential diagnosis and therapeutical effect of pancytopenia patients, the differences between bone marrow smear and trephine biopsy in degree of cellularity, misdiagnosis rate and therapeutical effect for 71 patients with pancytopenia were analyzed. The results showed that the degree of cellularity in bone marrow biopsy for cytologic morphology was higher than that from the smear, but misdiagnosis rate in the biopsy was lower than that in the smear. In conclusion, bone marrow biopsy is necessary to the differential diagnosis and more valuable for evaluation of therapeutical effect and prognosis of pancytopenia patients.

目的:比较骨髓活检与涂片两种方法诊断非霍奇金淋巴瘤骨髓浸润(NHLBMI)的价值.方法:分析57例非霍奇金淋巴瘤(NHL)患者骨髓活检与涂片检查结果.结果:57例NHL患者中21例骨髓活检存在淋巴瘤骨髓浸润,阳性率为36.8%,11例骨髓涂片阳性,阳性率为19.3%,骨髓活检阳性率高于骨髓涂片(P＜0.05).结论:骨髓活检可提高NHLBMI诊断率,骨髓活检与涂片相结合对NHL诊断和分期具有十分重要意义.