Objective:To investigate the harvest site complication and long term graft patency rate between autologous radial artery and great saphenous vein for coronary artery bypass grafting(CABG) in elder patients.Methods:We retrospectively analyzed 332 patients at(66.0±4.9) years of age who received CABG with autologous radial artery and great saphenous vein at the same time in our hospital from 2004 to 2010,and compared their early harvest site complication and long term graft patency rate between those 2 kinds of vessels.Before harvest,the radial artery was routinely examined by Doppler ultrasound,and calcium antagonist was used for anti-spasm after the procedure.Result:The in-hospital death were 6/332(1.8%) of patients.There were no significant differences in harvest site pain,hematoma and the limitation of activity between 2 kinds of grafting vessels,P005.While the incidences of numbness,swelling and infection in radial artery harvest site were obviously lower than those in great saphenous vein,P0.05 respectively.There were 307/332(92.5%) of patients follow-up by December 2012 and 177 patients received coronary angiography or CTA examination for graft patency at(58.0±23.7) months after the procedure.The graft patency rates of radial artery and great saphenous vein were 149/177(84.2%) vs.126/177(71.2%),P0.05.Conclusion:With pre-operative ultrasound evaluation and suitable anti-spasm treatment,radial artery could be a better alternative vessel for CABG than that of great saphenous vein in elder patients.

Objective:To investigate the role of B7-H4 in the development of gastric cancer(GC).Method:The expression of B7-H4 and microvessel density(MVD) in 60 excised gastric tumors were evaluated immunohistochemiscally.Results:B7-H4 was high expressed(71.7%)in gastric cancer. However, significantly fewer microvessel density was identified in B7-H4 negative tumor specimens than in B7-H4-positive tumor specimens. Conclusion:B7-H4 may be a new marker of diagnosis for gastric cancer;The blockade of B7-H4 in gastric cancer might be one strategy to pursue for future immunotherapy in gastric cancer.

In the time of drug-eluting stents,the incidence of in-stent restenosis has been significantly reduced.On the contrary,because of delayed endothelial healing,the patients complicated with late and very late in-stent thrombosis have higher mortality and incidence of acute myocardial infarction,which gradually attracts our attention.However,the exact mechanism is still not clear.This paper will expound the current situation and possible mechanisms of the late in-stent thrombosis occurred after drug-eluting stent implantation.

目的:探讨护士组织支持感对工作压力、工作倦怠的影响,从组织支持的视角寻找缓解工作倦怠的方法.方法:将工作压力与组织支持感分为高低两个的分组,根据交互作用检验并通过比较边际平均数的方法分析组织支持感在工作压力与工作倦怠中的作用.结果:组织支持感与工作压力的交互作用显著,组织支持感具有明显降低由工作压力所产生的工作倦怠的作用.结论:从增强员工组织支持感的视角采取措施缓解护士的工作压力及工作倦怠.

目的:研究恩替卡韦治疗HBeAg阳性慢性乙型肝炎期间PBMC中HBV DNA水平与HBeAg血清转换率的相关性.方法:77例HBeAg阳性慢性乙型肝炎患者,随机分为对照组(40例)和治疗组(37例),治疗组给予恩替卡韦0.5 mg/d治疗＞48周,于治疗的0、4、12、24、48周时分别测定乙型肝炎病毒血清标志物、血清及PBMC中HBV DNA水平.结果:治疗48周时治疗组血清及PBMC中HBV DNA阴转率均显著高于对照组,治疗组初始治疗前患者PBMC中HBV DNA阳性率为78.4％,随治疗疗程的延长血清及PBMC中HBV DNA阳性率降低.治疗组初始治疗时PBMC中HBV DNA阴性的患者治疗48周时E抗原血清转换率高于初始治疗时PBMC中HBV DNA阳性的患者(P＜0.05).结论:恩替卡韦对血清及PBMC中HBV DNA均有明显的抑制作用；PBMC中HBV DNA阴转对预测HBeAg血清转换有一定价值.