针对培养高素质药学专业技术人才的要求,该文提出了一种由药学各主干专业课交叉融合、基于药物开发过程的综合实验教学模式.初步实践证明该项目能促进专业知识的积累与整合、培养学生的综合设计能力,成功连接专业理论与生产实践,为药学高等教育提供了一种新的实验教学模式.

根据高等教育及重点高等教育和经济发展的内涵关系建立相应的生产函数模型,运用近六年的数据测算高等教育及重点高等教育对经济发展的贡献率.结果表明,我国经济发展对高等教育的贡献率远大于高等教育对经济发展的贡献率;重点高等教育的贡献率在同人数的情况下优于一般高等教育的贡献率.

In this paper,The grey action quantity b in GM(2,1) model has been improved to b1 + b2k.By using the new grey action quantity,we construct an optimum GM(2,1)model and improve the corresponding boundary conditions.The application examples show that the optimum model is superior to the accumulating method GM(2,1) model and the reverse accumulating GM(2,1) model in prediction and simulation.

Experimental teaching is a very important link of the college pharmaceutical education and the laboratory is an important platform for effective experimental teaching, which can cultivate students' ability and professional skills training.The original operation mode should be reformed and specification with the increase of teaching and scientific research tasks and the expansion of the experimental center.This paper carries on the exploration and practices based on the current problems in the operation of the laboratory, such as function module partition, experimental contents adjustment, system construction, personnel construction, safety prevention and control, etc.

利用灰色模型的指数特性,对一类灰作用量优化的GM(1,1)模型,通过积分构建合适的背景值,并把白化方程中灰作用量b1+ b2t改进为(b1 +0.5b2)+b2t,同时采用灰色系统理论的新信息原理,进而得到优化的GM(1,1)灰色模型.实例计算表明改进模型具有良好的模拟预测精度,特别对于指数序列模拟和预测精度几乎达到100％,对指数序列来讲是一种比较优秀的拟合和预测模型.

Multi-dimensional nonlinear integer programming problem is a very important, nonlinear knapsack problem is a bounded nonlinear integer programming problem that maximizes a separable nonlinear function subject to multiple separable nondecreasing constraints. This problem is often encountered in resource allocation,industrial planning and computer network.In this paper,a new convergent Lagrangian dual method was proposed for solving this problem,the improving cutting plan method was used to solve the dual problem quickly. and to compute the Lagrangian bounds of the primal problem.In order to eliminate the duality gap and thus to guarantee the convergence of the algorithm,domain cut technique was employed to remove certain integer boxes and partition the revised domain to a union of integer boxes.Our numerical results indicate that the improving cutting plane method significantly outperforms is very efficient as a dual search procedure.

甜菜碱(betaine,Bet)又名甘氨酸甜菜碱、甜菜素,化学名称是三甲基氨基乙酸或三甲铵乙内酯,19世纪最早发现于欧洲,是一种季铵型水溶性生物碱,广泛存在于动植物和微生物体内.

Betaine,as a methyl donor,is distributed widely in animals,plants,and microorganisms.It participates in an important biochemical reaction——the methionine cycle in organism.Betaine can obviously improve the symptoms due to lacking of methyl group in organism,and can be used to treat hyperhomocysteine syndrome,protect liver and kidney,heart and blood vessels.It also has lots of other beneficial pharmacological effects such as inhibition of unceasingly growing tumor cells and protection of cells against hyperosmotic damage.This paper summarized the current status of studies on the pharmacodynamics of betaine and the possible mechanisms.

Objective:To study auxiliary problem method for solving implicit complementarity problems.Methods:The generalized momotonicity definition and some classical conclusions were first introduced.Results:A class of iterative method built on the auxiliary problem principle for solving implicit complementarity problem were suggested and analyzed,and the equivalence of implicit complementarity problem and generalized variational inequalities and the convergence of this method were proved.Conclusion:The corresponding conclusions of the classical complementarity problem are generalized.