A well-known global public health issue, osteoarthritis (OA) primarily affects the elderly. Although the etiology of OA remains unknown, immune and inflammatory factors are considered nonnegligible risk factors. This study investigated the association between the systemic immune-inflammatory index (SII) and the risk of OA. Based on data from the National Health and Nutrition Examination Survey (NHANES), laboratory testing, basic information, and questionnaires were collected for cross-sectional analysis from a total of 15,317 adults during 2013–2018. In this study, the exposure variable was systemic inflammatory status as defined by SII, and the outcome was OA. Due to the complex survey design and sample weighting, we employed multiple logistic regression models and stratified analyses to evaluate the association between SII and OA. In addition, using an interaction test, we examined the relationship between SII, OA, and other variables. This study included a total of 15,317 participants, of whom 2207 were diagnosed with OA. Compared with the non-OA group, participants in the OA group had a significantly higher SII level. After adjusting for all covariates, log SII was positively associated with OA prevalence (OR = 1.27, 95

BACKGROUND:The optimal surgical strategy for treating displaced intra-articular calcaneal fractures remains controversial. PURPOSE:The purpose of this retrospective cohort study was to compare the clinical and radiologic outcomes of percutaneous cannulated screw fixation versus open reduction and plate fixation via the sinus tarsi approach in patients with displaced intra-articular Sanders II or III calcaneal fractures. STUDY DESIGN:A retrospective analysis was performed on the records of patients with displaced Sanders II or III calcaneal fractures. METHODS:We analyzed data from 124 patients using propensity score matching applied at a 1:1 ratio. The primary outcome was assessed using the American Orthopaedic Foot and Ankle Society ankle-hindfoot scale for evaluating ankle function. Secondary outcomes included radiological outcomes, operative time, postoperative Visual Analogue Scale, wound complication rates, and hardware removal rates. RESULTS:There was no statistical difference in the American Orthopaedic Foot and Ankle Society ankle-hindfoot Scale (p=.104) and radiological outcomes (Böhler's angle, p=0.21; Gissane's angle, p=0.29) between the two groups. The percutaneous cannulated screw fixation group demonstrated better ankle-hindfoot complex motion, shorter operative time (65±35 mins vs 95±40 mins), lower postoperative Visual Analogue Scale (5±1 vs 8±1.5), fewer wound complications (3.2 % vs 9.6 %), and no hardware removal needed (0 % vs 14.5 %). CONCLUSION:This study suggests that both techniques achieved comparable functional and radiographic outcomes for displaced intra-articular Sanders II or III calcaneal fractures; however, percutaneous cannulated screw fixation demonstrated favorable advantages in several aspects.

Rheumatoid arthritis (RA) significantly drives global morbidity and mortality, yet its evolving impact in low- and middle-income countries remains underexplored. This study harnesses extensive global burden of disease (GBD) data to delineate the temporal trends of RA burden in the Islamic Republic of Pakistan from 1990 to 2021, examine its association with socio-demographic development, and forecast future trajectories through 2036. This retrospective epidemiological study quantified RA disease metrics in Pakistan through GBD data interrogation. Joinpoint regression modeling delineated temporal trajectories, calculating average annual percent change (AAPC) with 95% confidence intervals (CIs). Spearman's rank correlation assessed the relationship between socio-demographic index (SDI) values and age-standardized rates (ASRs) of RA across 204 regions. A Bayesian age-period-cohort (BAPC) model was employed to project RA burden trends in Pakistan from 2022 to 2036. Stratified comparative assessments revealed age- and sex-specific demographic disparities. Although age-standardized incidence rate (ASIR) and age-standardized prevalence rate (ASPR) exhibited modest declines (AAPC: -0.10% and - 0.09%, respectively), the absolute numbers of incident and prevalent RA cases increased markedly-from 8,606 to 19,454 and from 134,628 to 318,963, respectively-between 1990 and 2021. Mortality rates showed a slight upward trend (AAPC: 0.35%), with total deaths rising from 478 to 1,006, while Disability-adjusted life years (DALYs) nearly doubled, increasing from 27,314 to 62,774. Age-specific analyses revealed peak incidence among younger individuals (20-24 years) and higher mortality and DALYs among older populations, particularly those aged 75 and above. Additionally, females consistently experienced a greater burden across all metrics compared to males. SDI exhibited significant positive correlations with ASIR (r = 0.42), ASPR (r = 0.47), age-standardized mortality rate (ASMR) (r = 0.32), and age-standardized DALYs rate (ASDR) (r = 0.46; all p < 0.001), indicating that higher socio-demographic development was associated with a greater documented RA burden. BAPC projections forecast a gradual decline in age-standardized RA rates through 2036, although absolute case numbers are expected to remain high owing to population growth and demographic aging. The RA burden in Pakistan has escalated over the past three decades, with higher-SDI regions demonstrating disproportionately greater age-standardized rates and documented cases. Despite anticipated per-capita declines in RA incidence, prevalence, mortality, and DALYs by 2036, demographic shifts will likely sustain a substantial absolute burden. These findings emphasize the necessity of precise public health measures to advance early diagnosis, optimize disease management, and reinforce prevention-particularly in rapidly developing areas and among high-risk groups such as women and the elderly.

Pediatric heart failure(HF)is a clinical syndrome of compro-mised ventricular systolic or diastolic function,presenting with exertional fatigue,respiratory distress,peripheral/pulmonary edema,and failure to thrive.Its precise prevalence has not been definitively established in existing epidemiological studies due to diagnostic challenges and population heterogeneity,reported ranging from 0.87 in the United Kingdom and Ireland,2.0 to 3.0 in Germany and China per 100,000 children[1].The burden of pediatric HF hospitalization in China account for approximately 40,000 admissions annually,with distinct mortality rate across dis-ease stages:chronic compensated HF demonstrates 30％all-cause mortality at 3-year follow-up,whereas advanced or end-stage HF(described as severe,refractory cardiac dysfunction resulting in profound functional limitation and a dependence on medical ther-apy to manage symptoms and sustain cardiac output[2])exhibit catastrophic 80％at 5-year mortality despite optimal medical ther-apy.Moreover,HF management accounts for an annual healthcare expenditure exceeding $108 billion globally.High prevalence,excess mortality,and heavy financial burden underscore its emer-gence as a critical public health priority.

The tube posterior tibial artery flow-through free flap technique is proposed for salvaging upper limbs with severely contaminated or infected soft tissue defects and major arterial injuries. Between January 2016 and February 2024, six patients were treated using this method. This is a two-stage approach involving initial restoration of blood supply via a tube posterior tibial artery flow-through free flap, followed by delayed soft tissue coverage utilizing the unfolded tube flap after a series of wound debridements and vacuum sealing drainage treatments. All upper limbs and flaps completely survived. At the 2-year follow-up, the grip and pinch strength of the injured hands reached 37% (range 29-72%）and 31% (range 12-42%) of the contralateral sides, respectively. The mean Disabilities of the Arm, Shoulder, and Hand score was 60 (range 53-67). This study demonstrates the feasibility and efficacy of the tube posterior tibial artery flow-through free flap technique in complex upper limb salvage cases.Level of evidence: IV.

Longitudinal melanonychia (LM) is a common nail disorder that sometimes requires surgical excision to rule out malignancy. However, longitudinal complete removal of LM, as one type of method for some special patient, can leave a significant defect in the nail bed. We introduced and assessed the application of transverse V-Y advancement composite tissue flap, a novel surgical procedure designed to address these defects. From September 2017 to January 2024, a total of 17 patients with LM underwent complete excision of the affected nail bed. The tissue defects ranged from 3 to 8 mm in width. The wounds were repaired using the transverse V-Y advancement composite tissue flap, which included the nail, nail fold, and adjacent finger pulp skin. All patients were followed up to assess flap survival, nail regrowth, and functional outcomes, and the mean follow-up time was 14 months, with a range of 6-23 months. All 17 flaps survived without complications. Nail regrowth was satisfactory in 15 cases, with only 2 cases showing a slight longitudinal ridge. Sensory recovery was well in all patients. Recurrence of LM was observed in 1 case (5.9%) during the follow-up period. The transverse V-Y advancement composite tissue flap is a reliable and effective alternative for repairing defects after LM complete excision identified as the indicating lesion, particularly for defects ranging from 3 to 8 mm in width. This technique significantly improves both functional and cosmetic outcomes, with high patient satisfaction.

Acute Osteofascial Compartment Syndrome (AOCS) stands as a critical surgical emergency, often secondary to various diseases. Its clinical manifestation arises from increased pressure within the fascial compartment, resulting in diminished tissue perfusion and consequential ischemic damage. Presently, clinical diagnostics lack effective biological markers, and patients face a grim prognosis, experiencing muscle contractures, necrosis, amputations, renal failure, and even mortality. The primary treatment, fasciotomy, poses infection risks and potential nerve damage. Hence, there is an urgent need for research elucidating AOCS's pathogenic mechanism and exploring novel treatments. To address this, we established a rat model of AOCS, extracting toe flexor muscles from both experimental and control groups. Employing second-generation high-throughput sequencing, we obtained comprehensive mRNA, lncRNA, circRNA, and miRNA data. Comparative analysis of expression differences between AOCS and control groups, followed by in-depth examination, allowed us to unravel the intricacies of AOCS occurrence from a multi-omics perspective. Our research findings indicate that AOCS is an immune-mediated inflammatory disease, primarily involving immune cells, especially neutrophils. In addition, genes associated with ferroptosis, a form of regulated cell death, are found to be upregulated in the rat model, with non-coding RNAs playing a role in regulatory interactions. These results suggest that neutrophils may undergo ferroptosis, thereby enhancing inflammation and immune responses in the fascial compartment, which promotes disease progression. Furthermore, these findings reveal the interactions between immune molecules and pathways in AOCS, which are significant for a deeper understanding of the pathogenesis of the disease and the development of targeted therapeutic strategies.

In recent years, the incidence of tibial plateau fractures (TPF) has been on the rise. Deep vein thrombosis (DVT) may lead to poor prognosis in patients. The systemic immune-inflammation index(SII) are novel biomarkers of inflammation, and this study aims to verify their predictive effect and construct the nomogram model. This study used binary logistic regression analysis to predict the predictive effect of SII on the occurrence of DVT in tibial plateau fracture patients. And use R studio to construct nomogram model. The results showed that Age (1.03 [1, 1.06], p = 0.032), SII (3.57 [1.68, 7.61], p = 0.04), and NC (7.22 [3.21, 16.26], p < 0.001) were independent predictive factors for DVT. The nomogram demonstrated good predictive performance with small errors in both the training and validation groups, and most clinical patients could benefit from them. The nomogram constructed based on SII can assist clinicians in early assessment of the probability of DVT occurrence.

Background In recent years, the incidence of tibial plateau fracture has been on the rise, predominantly affecting the elderly population. Deep vein thrombosis may lead to poor prognosis in patients. the Systemic Inflammatory Response Index are novel biomarkers of inflammation, and this study aims to verify their predictive effect and construct the nomogram model. Method This study used binary logistic regression analysis to predict the predictive effect of SIRI on the occurrence of DVT in tibial plateau fracture patients. And use R studio to construct nomogram model. Result The results showed that NC (7.036 [3.516, 14.080], p < 0.001), LYM (0.507 [0.265, 0.969], p = 0.04), and SIRI (2.090 [1.044, 4.182], p = 0.037) were independent predictive factors for DVT. The nomogram demonstrated good predictive performance with small errors in both the training and validation groups, and most clinical patients could benefit from them. Conclusion The nomogram constructed based on SIRI can assist clinicians in early assessment of the probability of DVT occurrence.

In recent years, the incidence of pelvic fractures has been on the rise, predominantly affecting the elderly population. Deep vein thrombosis may lead to poor prognosis in patients. monocyte-to-lymphocyte ratio is novel biomarkers of inflammation, and this study aims to verify their predictive effect and construct the nomogram model. This study used binary logistic regression analysis to predict the predictive effect of MLR on the occurrence of DVT in pelvic fractures patients. And use R studio to construct nomogram model. The results showed that Age (1.04 [1.01, 1.07], p = 0.006), WBC (1.44 [1.28, 1.61], p < 0.001), and MLR (2.11 [1.08, 4.13], p = 0.029) were independent predictive factors. The nomogram demonstrated good predictive performance with small errors in both the training and validation groups, and most clinical patients could benefit from them. The nomogram constructed based on MLR can assist clinicians in early assessment of the probability of DVT occurrence.

Background This study aims to develop a nomogram and forecast the incidence of DVT in individuals suffering from an intertrochanteric femur fracture. Method This work created a nomogram using the R programming language and employed logistic regression to determine independent predicting features. An external validation dataset was used to validate the nomogram. Result The findings demonstrated the independence of LYM (0.02[0.01–0.09], p < 0.001), ALB (0.83[0.74, 0.94], p = 0.002), and HDL-C (0.18[0.04, 0.71], p = 0.014). Good prediction performance with modest errors was shown by the nomogram in both the training and validation groups. Conclusion In conclusion, the nomogram that was created using HDL-C, ALB, and LYM can assist medical professionals in determining the likelihood that DVT will occur.

BACKGROUND:Acute compartment syndrome(ACS) is a perilous consequence of trauma. Acute compartment syndrome's precise cause is yet unknown. We performed studies to confirm that acute compartment syndrome can be relieved by suppressing ferroptosis and activating the Nrf2/Hmox1 pathway. METHODS:We generated an ACS rat model and we conducted next-generation sequencing(NGS) of skeletal muscle tissue and identified differentially expressed target genes. Ultimately, we performed in vivo experiments to validate the presence of ferroptosis and the Nrf2/Hmox1 pathway in ACS rats. After the minocycline intervention, the drug was evaluated for its effects on ACS by examining changes associated with ferroptosis. RESULTS:The bioinformatics analysis identified that the genetic changes in the disease were mostly focused on ferroptosis, with noticeable modifications in Nrf2/Hmox1. Based on the in vivo results, it was observed that ACS rats exhibited significantly elevated levels of ferroptosis compared to the control rats. The suppression of the Nrf2/Hmox1 pathway mediated by minocycline improves outcomes in ACS and reduces tissue damage after intervention. CONCLUSION:Minocycline hinders ferroptosis via stimulating the Nrf2/Hmox1 pathway, which slows down the advancement of acute compartment syndrome.

Background Amputation is a serious complication of acute compartment syndrome (ACS), and predicting the risk factors associated with amputation remains a challenge for surgeons. The aim of this study was to analyze the risk factors for amputation in patients with ACS and develop a nomogram to predict amputation risk more accurately. Methods The study population consisted of 143 patients (32 in the amputation group and 111 in the limb preservation group) diagnosed with ACS. LASSO and multivariate logistic regression were used to screen predictors and create a nomogram. The model’s accuracy was assessed by receiver operating characteristic (ROC) curves, C-index, calibration curves, and decision curve analysis (DCA). Results The predictors included cause of injury, vascular damage, shock, and fibrinogen in the nomogram. The C-index of the model was 0.872 (95% confidence interval: 0.854–0.962), and the C-index calculated by internal validation was 0.838. The nomogram’s area under the curve (AUC) was 0.849, and the calibration curve demonstrated a high degree of agreement between the nomogram’s predictions and actual observations. Additionally, the DCA indicated good clinical utility for the nomogram. Conclusion The risk of amputation in ACS patients is associated with the cause of injury, vascular damage, shock, and fibrinogen. Our nomogram integrating clinical factors and biochemical blood markers enables doctors to more conveniently predict the risk of amputation in patients with ACS.

Abstract Background: Sarcopenia is a disorder of the skeletal muscles characterized by a reduction in muscle mass, strength, and function. This investigation investigates the potential causal connection between inflammatory cytokines and sarcopenia. Methods: Using two genome-wide association studies (GWAS), we performed bidirectional Mendelian randomization (MR) analysis. The statistical analyses mainly included inverse variance-weighted (IVW), weighted median (WM), MR-Egger, Cochran's Q test, MR-Egger intercept analysis, and MR-PRESSO. Results: By the European Working Group on Sarcopenia in Older People (EWGSOP) criteria, we observed an inverse correlation between IL16 and sarcopenia (IL16, odds ratio [OR]: 0.971, 95% confidence interval [CI]: 0.948-0.995, P = 0.0199). In contrast, IL5 and MIP1b were positively associated with sarcopenia (IL5, OR: 1.063, 95% CI: 1.006-1.124, P = 0.0294; MIP1b, OR: 1.022, 95% CI: 1.001-1.043, P = 0.0375). Using the Foundation for the National Institutes of Health (FNIH) standard, we found an inverse association between IL16 and the risk of developing sarcopenia (IL16, OR: 0.954, 95% CI: 0.917-0.993, P = 0.0223). In contrast, MIP1b showed a positive association with the risk of sarcopenia (MIP1b, OR: 1.027, 95% CI: 1.000-1.055, P = 0.0491). We observed a weak negative correlation between IL16 and appendicular lean mass (ALM) regarding muscle mass analysis (IL16, OR: 0.990, 95% CI: 0.980-0.999, P = 0.0498). Reverse magnetic resonance analysis revealed no causal relationships between sarcopenia and IL16, IL5, or MIP1b. Conclusion: Our research reveals a negative correlation between IL16 and genetic susceptibility to sarcopenia, indicating that IL16 protects effect on sarcopenia. In contrast, IL5 and MIP1b are positively associated with the risk of sarcopenia, suggesting they may be detrimental to muscle health.

Injectable hydrogels possess tremendous merits for use in muscle regeneration; however, they still lack intrinsic biological cues (such as the proliferation and differentiation of myogenic cells), thus considerably restricting their potential for therapeutic use. Herein, we developed a double cross-linked injectable hydrogel composed of methacrylamidated oxidized hyaluronic acid (MOHA) and muscular decellularized matrix (MDM). The chemical composition of the hydrogel was confirmed using 1H NMR and Fourier transform infrared spectroscopy. To achieve cross-linking, the aldehyde groups in MOHA were initially reacted with the amino groups in MDM through a Schiff-based reaction. This relatively weak cross-linking provided the MOHA/MDM hydrogel with satisfactory injectability. Furthermore, the methacrylation of MOHA facilitated a second cross-linking mechanism via UV irradiation, resulting in improved gelation ability, biomechanical properties, and swelling performance. When C2C12 myogenic cells were loaded into the hydrogel, our results showed that the addition of MDM significantly enhanced myoblast proliferation compared to the MOHA hydrogel, as demonstrated by live/dead staining and Cell Counting Kit-8 assay after seven days of in vitro cultivation. In addition, gene expression analysis using quantitative polymerase chain reaction indicated that the MOHA/MDM hydrogel promoted myogenic differentiation of C2C12 cells more effectively than the MOHA hydrogel, as evidenced by elevated expression levels of myogenin, troponin T, and MHC in the MOHA/MDM hydrogel group. Moreover, after four to eight weeks of implantation in a full-thickness abdominal wall-defect model, the MOHA/MDM hydrogel could promote the reconstruction and repair of functional skeletal muscle tissue with enhanced tetanic force and tensile strength. This study provides a new double cross-linked injectable hydrogel for use in muscular tissue engineering.

Combining the synergistic effect of single-atom catalysts and nanoparticles (NPs) to improve the catalytic activity may be promising in the design of nanozymes, although it only applies in the field of electrocatalysis. Herein, we designed a polyatomic SOD and CAT-mimicking Pt/Co-SA-NSG nanozyme composed of ultrafine Pt NPs and Co-SA-NSG with atomically dispersed Co and N, S co-doped graphene for OA treatment. Results demonstrated the Pt/Co-SA-NSG nanozyme has dual active centers containing Co-N4 and Pt and effective scavenging effect of reactive oxygen species (ROS), possibly due to that the electron orbital overlap between Co single atoms and Pt NPs enhanced the electron transport interaction to increase the adsorption energy of free radicals and reduce the reaction energy. Based on the H2O2 induced chondrocytes and OA joint model, Pt/Co-SA-NSG nanozyme exhibited biosafety, high photothermal conversion performance (54.56%), excellent SOD and CAT-like enzyme activities, and ROS scavenging ability. Particularly, in combination with NIR II irradiation therapy, Pt/Co-SA-NSG nanozyme could greatly relieved the OA progression with a Pelletier Score reduction of 54.54%. Mechanistically, the Pt/Co-SA-NSG nanozyme can restore mitochondrial function, thereby regulate ATP level, so as to reduce inflammatory factors level and increase antioxidant factors level. This novel nanozyme was expected to guide the design and activity enhancement of other nanozymes in the future.

Acute compartment syndrome (ACS) is a life-threatening orthopedic emergency, which can even result in amputation. Ferroptosis is an iron-dependent form of nonapoptotic cell death. This study investigated the mechanism of ferroptosis in ACS, explored candidate markers, and determined effective treatments. This study identified pathways involved in the development of ACS through gene set enrichment analysis (GSEA), Gene Ontology, Kyoto Encyclopedia of Genes and Genomes (KEGG), and GSEA of heme oxygenase 1 (Hmox1). Bioinformatics methods, combined with real-time quantitative polymerase chain reaction, western blot analysis, and iron staining, were applied to determine whether ferroptosis was involved in the progression of ACS and to explore the mechanism of nuclear factor erythroid-2-related factor 2 (Nfe2l2)/Hmox1 in ferroptosis regulation. Optimal drugs for the treatment of ACS were also investigated using Connectivity Map. The ferroptosis pathway was enriched in GSEA, KEGG of DEGs, and GSEA of Hmox1. After ACS, the reactive oxygen species content, tissue iron content, and oxidative stress level increased, whereas glutathione peroxidase 4 protein expression decreased. The skeletal muscle was swollen and necrotized; the number of mitochondrial cristae became fewer or even disappeared, and Nfe2l2/Hmox1 expression increased at the transcriptional and protein levels. Hmox1 was highly expressed in ACS, indicating that Hmox1 is a possible marker for ACS. we could predict 12 potential target drugs for the treatment of ACS. In conclusion, Hmox1 was a potential candidate marker for ACS diagnosis. Ferroptosis was involved in the progression of ACS. It was speculated that ferroptosis is inhibited by the Nfe2l2/Hmox1 signaling pathway.

Objective This study aimed to identify key gene modules and hub targets in acute compartment syndrome (ACS). Methods Transcriptome sequencing was performed on the flexor digitorum longus of control and experimental rats and differentially expressed genes (DEGs) were identified by bioinformatics methods. protein-protein interaction (PPI) network and key gene modules were constructed using DEGs to identify hub genes. Enrichment analysis was performed on the core gene set, and the hub genes were validated. Results We determined 548 DEGs by transcriptome sequencing of the flexor digitorum longus of 5 normal rats and 5 ACS rats. The 548 DEGs were uploaded to String and analyzed using Cytoscape, and 397 DEGs were selected to construct PPI network. molecular complex detection (MCODE) was used to cluster important gene modules to obtain a key module composed of 27 genes, and friends analysis demonstrated that myeloid differentiation factor88 (MyD88) had the most important position in these genes. Through enrichment analysis of the core gene set identified by MCODE, we found that the core gene set was highly enriched in biological process (BP) related to the inflammatory response (such as inflammatory response, positive regulation of leukocyte migration, and response to interleukin 1) and Kyoto Encyclopedia of Genes and Genomes (KEGG) (such as TNF signaling pathway, NF-κB signaling pathway, etc.). Conclusion ACS is accompanied by a significant inflammatory response, and screening drugs to inhibit MyD88 or TLR/MyD88/NF-κB signaling pathway to reduce inflammation may have a certain effect on the treatment of ACS. MyD88 also provides a possible candidate biomarker for the diagnosis of ACS. Our study provides new insights into the pathogenesis of ACS and potential molecular targets for finding new diagnostic and treatment methods.

在新冠肺炎疫情的影响下,许多高校开设了网络课堂.发展在线教育,有利于学生更便捷地获取各种教育资源,为学生提供一个良好的学习平台.网课教学作为一种新的教学模式,具有教学时间空间灵活、能够培养学生自主学习能力以及评价方式灵活等优势.由于网络教学还处于起步阶段,仍存在一些不足之处.对于网络课堂这种新的教学模式,既要看到它的优点,也要认识到它存在的问题,只有不断地完善网课教育平台的服务能力,才能为广大学生提供更优质的教育资源.

目的:分析2010-2019年广西南宁市急性骨筋膜室综合征(ACS)截肢发生率的变化趋势及危险因素,为预防其发生提供参考.方法:收集2010-2019年南宁市6家综合医院诊治的ACS患者的临床资料,采用单因素及多因素Logistic回归分析影响患者发生截肢的危险因素.结果:共收集378例患者,其中截肢64例,总截肢率为16.93％;2010-2019年期间,广西南宁市ACS患者的截肢率呈下降趋势(P趋势＜0.05).多因素Logistic回归分析显示:高能量损伤(OR=2.136,95％CI:1.050～4.343)、合并血管损伤(OR=2.553,95％CI:1.301～5.011)、合并感染(OR=3.120,95％CI:1.539～6.327)、转院治疗(OR=4.164,95％CI:1.853～9.354)以及未切开减压(OR=5.383,95％CI:1.143～25.348)是患者截肢的危险因素.结论:广西南宁市ACS的截肢率呈下降趋势;高能量损伤、合并血管损伤、合并感染、转院治疗以及未切开减压是ACS患者发生截肢的危险因素.