In this paper,in order to cultivate students＇ autonomous learning ability,reform of self-study course had been made on the introduction of basic medicine,and good effect had been got.In the teaching reform,the following efforts have been made:sublimating both teachers and students＇educational ideas to adopt student-centered teaching model,and creating a positive self-study environment for students by improving teachers＇ instructions and teaching students learning strategies,and reforming the course assessment system to examine and evaluate student' s performances in the whole process of the course study so as to improve learning efficiency.

Objective To explore the effect of melatonin(MT) on the behavior of rats treated with noise stress and the related bio-mechanism. Methods Fifty rats were randomly divided into a blank group,two experimental groups and two control groups. The blank group was untreated. The experimental and control groups were exposed to 120dB noise stress for 1 day or 3 days, 8 hours per day, and treated with 15 mg/kg melatonin by intraperitoneal injection,or the same volume of physiological saline 30 minutes before noise stress. After noise stress,the rats' behavior was measured by open field test, learning and memory ability of rats was investigated with the method of Morris water maze and then nitric oxide (NO), superoxide dismutase (SOD) and malondialdehyde (MDA) contents in cerebral cortex and hippocampus of the rats were measured by TBA and Griess method respectively. Results No matter noise stress time was 1 day or 3 days, the excitability and explorative behavior of the 2 experimental groups(total movement distance (TMD) (1322.50 ± 504.32) cm, (1819.55 ± 458.37) cm, faster movement time (FMT) (68.49 ± 23.90) s, (87.34 ± 16.01) s, distance to center (DTC) (63.56 ± 2. 75) cm, (60. 13 ±1.87)cm, inner toriod time(ITT) (7.87 ±2.06)s,(9.60 ±2.89)s) in the open field test decreased significantly compared with those of the control group (TMD (2042.03 ± 449. 19) cm, (2325.73 ± 384.90) cm,FMT (109.32 ±21.84)s,(124.65 ± 16.74)s, DTC (58.00± 1.53)cm,(55.05 ±5.13)cm, ITT (12.84 ±3.62) s, (14.92 ± 2.75) s, P ＜ 0. 05, P ＜ 0.01);the escape latency of the experimental groups (( 10. 69 ±3.37) s, (18.87 ± 4.74) s) in Morris water maze was significantly shorter than that of the control group (( 23.86± 7.66)s, (33.55 ± 7.20)s, P＜ 0.05, P＜0.01). The contents of NO or MDA in cerebral cortex and hippocampus of the experimental groups (NO in cerebral cortex (3.35 ± 0.40) μmol/gprot, (4.50 ± 0.41) μmol/gprot, NO in hippocampus (2.24 ±0.18) μmol/gprot,(3.15 ±0.21) μmol/gprot, MDA in cerebral cortex(1.34 ±0.44)nmol/mgprot, (2.39 ± 0. 18) nmol/mgprot, MDA in hippocampus (0. 13 ± 0. 07) nmol/mgprot, (0.53 ± 0. 10)nmol/mgprot) were lower than those of the control group (NO in cerebral cortex (3.35 ± 0. 40) μmol/mgprot,(5.03 ± 0.44)μmol/mgprot, NO in hippocampus (2.93 ± 0. 31) μmol/gprot, (3.38 ± 0.24) μmol/gprot, MDA in cerebral cortex (2.24 ± 0.26) nmol/mgprot, (4.21 ± 0.21) nmol/mgprot, MDA in hippocampus (0.47 ± 0.29)nmol/mgprot, (1.33 ± 0. 187) nmol/mgprot, P ＜ 0.05, P ＜ 0. 01) respectively and the contents of SOD in cerebral cortex and hippocampus of the experimental groups (in cerebral cortex (763.95 ± 214.36) U/mgprot, (491.33 ±35.85) U/mgprot, in hippocampus (817.02 ± 232.39) U/mgprot, (644.85 ± 28.02) U/mgprot) were higher than those of the control group(in cerebral cortex (556.50 ± 101.51) U/mgprot, (327.35 ± 30.54) U/mgprot, in hippocampus (279.74 ± 117.02) U/mgprot, (108.75 ± 15.52) U/mgprot, P ＜ 0.05, P＜ 0.01) respectively. Conclusion Melatonin is effective in improving the ability of learning and memory in the rats of noise stress,possibly by inhibiting the increase of NO and MDA and increasing the SOD activity in cerebral cortex and hippocampus of the rats.

目的 研究依达拉奉是否能降低不稳定型心绞痛(UAP)患者血液基质金属蛋白酶9及氧化应激反应的水平.方法 2007年1月至2009年12月在本院心内科住院的UAP患者60例,随机分为A组和B组两组,各30例.A组采用基础药物治疗,B组在基础药物治疗的基础上,采用依达拉奉30mg静脉滴注,2次/d,共用10d.治疗前后测定血清高敏C-反应蛋白(hs-CRP)、丙二醛(MDA)、基质金属蛋白酶9(MM-9).选择同期门诊健康体检者30例作为对照组.用ELISA法测定血清hs-CRP、MM-9含量,TBA法测定MDA含量.结果 UAP患者hs-CRP、MDA、MM-9水平均明显高于健康人,基础药物治疗可以降低这些指标水平,依达拉奉治疗较基础药物治疗能更显著降低hs-CRP、MDA、MM-9水平.结论 依达拉奉作为自由基清除剂,对降低UAP患者体内氧化应激及炎症水平、对维持稳定粥样硬化斑块有一定作用,表明对改善UAP患者的预后有重要作用.

Considered the entropy of the objectivity and assign attributes recognition model in addressing the issue of the orderly division superiority,the attribute recognition model based on coefficient of entropy is applied to evaluate heavy metal pollution of the soil,and use this model to evaluate the soil environmental quality of the main vegetable bases in Urumqi.Compared the results of attribute recognition model and fuzzy mathematical models,and it shows that this model for evaluating heavy metal in soil is feasible and high precision.

Wettabilitv is one of important factors of influencing electrical resistance of reservoir rock.The experiment studies the changing laws of electrical resistance with oil saturation in the course of fresh water flooding of different wettability cores and discovers the electricity conducting principle of different wettability rocks after the oil layer water flooded. The results indicate that after fresh water flooding the changing curve of electrical resistance of water-wet core showsUandLform,but one of oil-wet core declines.So the change of electrical resistance of the rock is influenced by original wettability.The above studied achievements can provide technical support for the watered-out layer interpretation and residual oil saturation evaluation in different wettability oil reservoirs.

Taking the recycle of post-treatment water from the Yangli sewage treatment plant for example,the necessity and the foreground significance of reclaimed water recycle to the environment and social development in Fuzhou is introduced in the paper.Having analysed from aspects such as technology,economic policy in detail,it concluded that the recloaimed water from the Fuzhou Wastewater treatment Plant is a stable,safe,and sufficient source of water,and it was feasible in irrigating,municipal,flushing cars and lavatory etc.