目的:分析三阴性乳腺癌(triple negative-breast carcinoma,TNBC)临床病理特征及预后影响因素。方法:收集2005年1月至2008年12月就诊于河北医科大学第四医院乳腺癌手术患者的临床资料。回顾分析TNBC与非TNBC的临床、病理特征差异及TNBC预后影响因素。结果:TNBC在初诊时肿块较大、淋巴结转移阳性者较多,临床分期以Ⅱ、Ⅲ期为主,有乳腺癌家族史者较多,肺、肝转移率高。Cox回归分析显示,淋巴结状况、原发肿瘤大小是影响TNBC患者OS及DFS的两个主要因素。结论:TNBC与非TNBC在临床、病理特征上存在的差异较多,35岁以上TNBC患者预后更差。N、T为TNBC独立预后因素。

Molecular markers have been widely used in the treatment of breast cancer. Cell proliferation markers Ki-67 antigen representing breast neoplasms proliferative activity is associated with clinic pathological features and prognosis and has an important predictive value in assessing the effect of neoadjuvant chemotherapy and endocrine therapy. High expression of Ki-67 is a bad prognostic factor of breast cancer, which is highly related to tumor progression, metastasis and prognosis.