Objective To observe the effect of probiotic composition on depression with anxiety pain. Methods 97 patients with anxiety and depression were divided into the control group(48 cases) and the study group(49 cases).According to random number table, the control group was treated with paroxetine hydrochloride tablets routinely, and the study group was treated with probiotic composition. The physical and mental indexes of the patients in the two groups were compared with t-test and chi-square test 30 days later. Results TNF-α of patients in the control group 54.07±5.12 pg/mL,and that in the study group was 42.16±3.97 pg/mL, which were significantly lower than those in the control group(P＜0.05). The 5-HT of patients in the control group was 256.74±22.61 ng/mL, and that in the study group was 301.65±27.05 ng/mL, which was significantly higher than that in the control group(P＜0.05). SAS scores of patients in the control group were 55.28±5.41 points, and those in the study group were 47.91±4.62 points, which were significantly lower than those in the control group(P＜0.05). The SDS scores of the patients in the control group were 59.83±5.62 points, and those in the study group were 51.76±4.97 points, which were significantly lower than those in the control group(P＜0.05). The PSQI scores of the patients in the control group were 11.72±1.06 points, while that in the study group were 9.83±0.94 points, which were significantly lower than that in the control group(P＜0.05). The incidence of adverse reactions in the control group was 20.83％, while that in the study group was 6.12％, which was significantly lower than that in the control group(P＜0.05). Conclusion The probiotic composition is beneficial to reduce the level of TNF-a, promote the synthesis of 5-HT, alleviate anxiety, depression and insomnia symptoms, and reduce adverse reactions.

假性股动脉瘤是血肿在动脉穿刺处与动脉相通形成,由于瘤壁无动脉壁组织故称假性动脉瘤.现将我科11例假性股动脉瘤诊治体会报告如下.

Objective To observe the effect and security of combining metformin with insulin in treatment of type 2 diabetes mellitus with sulfonylureas failure.Methods Sixty patients with type 2 diabetes mellitus were divided into two groups:the first group(group:A) was treated by combining pre-mixed human insulin(Novolin 30R) with metformin(850 mg once a day);the second group(group B)was treated only by insulin(Novolin 30 R).The dosage of insulin was adjusted according to the level of blood glucose.Results The start isulin dosage and the effective insulin dosage in group A were significantly lower than that in group B(P<0.05).There were 3 cases with low blood glucose reaction in group B and 10 cases with light gastro-intestinal symptom in group A.Conclusions Using insulin combined with metformin is better than insulin alone in type 2 diabetes mellitus with sulfonylureas failure.