急诊观察室常常收治外伤病人,为减轻肿胀及出血,24 h内常规行局部冰敷,因肿胀部位多不规则,如头顶、鼻部、眼眶、关节等处,普通冰袋不能与冰敷面良好的接触,且普通冰袋不易固定,需要护士或病人用手持续托扶,导致冰敷效果欠佳[1],为确保病人冰敷效果,我科特设计出"舒贴掌式冰袋"并已取得国家实用新型专利.舒贴掌式冰袋除很好应用在外伤病人身上,还可广泛应用于其他需要进行冷疗的病人.现介绍如下.

Objective: To investigate the protective effects of Rhizoma Paridis total saponins(RPTS)on the rats subjected to two-hit induced by multiple fractures and lipopolysaccharide.Methods:Eighty-six Wistar rats were randomly divided into three groups,and were made to the model in accordance with the standard of two-hit animal model induced by multiple fractures and lipopolysaccharide,except the blank control group.1 hour later,rats in RPTS groups were given Rhizoma Paridis total saponins by intragastric administration.6 hours later,the concentrations of TNF-α、IL-1β and IL-6 in the blood serum of part rats were detected by ELISA(enzyme linked immunosorbent assay).The pathological changes of the lung tissues were examined with light microscope.The mortality rate were estimated from another part rats.Results:In RPTS groups,the concentrations of TNF-α、IL-1β and IL-6 in blood serum of rats were remarkably lower than model group(P<0.001).In the model group,the evidence of lung injury was discovered by light microscopy.In RPTS groups,the histological changes of lung injury were ameliorated.The mortality rate in RPTS groups was lower than the model.Conclusion:Rhizoma Paridis total saponins can protect the rats subjected to two-hit induced by multiple fractures and lipopolysaccharide by falling the concentrations of TNF-α、IL-1β and IL-6 in blood serum of rats and inhibiting acute lung injury