The total synthesis of natural product chalcone derivative,1,2-Dihydroparatocarpin A,was first synthesized in total yield of 21.8% by C-prenylation,protection of phenolic hydroxyl group,aldol condensation,cyclization of DDQ and cyclization of the p-toluenesulfonic acid catalyted from 4-hydroxybenzaldehyde and 2,4-dihydroxyacetophenone.The structures were confirmed by 1H NMR,IR and MS.
