Objective:To investigate the chest physical therapy on sputum drainage in elderly patients with lung cancer after treatment. Methods:the chest physical therapy in our hospital from 2012 October to 2013 October using the operation treatment of 40 cases of postoperative elderly patients, including deep breathing, effective sputum, chest percussion, vibration sputum, postural drainage, mechanical at raction. Results:after chest physical therapy, 40 patients with postoperative pulmonary infection occurred in 3 cases, including 2 cases of atelectasis, 1 cases died, the mortality rate was 0.25%, the cause of death was respiratory failure complicated with heart failure. Conclusion:through the chest physical therapy can decrease pulmonary infection, pulmonary atelectasis and other complications, to promote early recovery of patients have a positive effect.
环氧合酶(cyclooxygenase,COX),是花生四烯酸转化为前列腺素PGs的限速酶.COX有两个同工异构体:COX-1和COX-2,其中COX-1为原生型,在大多组织中都有不同水平的表达.COX-1在机体多数正常组织持续低浓度表达,其酶促产物参与维持正常生理功能,如保护胃肠道黏膜等,由COX-1合成的PGs在机体中具有保护性作用.而COX-2为诱生型,可因各种生长因子、丝裂原、内毒素、异生物素、激素、促肿瘤剂及癌基因等多种因素刺激而产生.
Objective:To study the expression of cyclooxygenase-2 (COX-2) in breast cancer tissue and normal epithelial tissue,and to study the relationship between COX-2 and the prognosis of the breast cancer.Methods:The primary breast cancer(n=98) and adjacent normal epithelial tissue(n=20) were analyzed for COX-2 expression by immunohistochemical method using specific monoclonal antibodies.Results:The expression of COX-2 in breast cancer and normal epithelial tissue had significant difference in statistics(P<0.05).A significant correlation was found between the survival period and pathological stage,estrogen receptor positive and P185 positive(RR=1 6.619,0.377,2.952 respectively).The five-year-survival rate of COX-2 positive expression was 80.9%,and 93.3% for negative expression(Log-Rank test,P=0.34)Conclusion:The cyclooxygenase-2 may be participated the whole course of carcinogenesis of breast cancer,but not is absolute factor for estimate the survival rate of the patients with breast cancer.
