目的 观察逍遥散治疗混合性焦虑抑郁障碍肝郁脾虚证的临床疗效.方法 采用随机、对照的方法,将150例混合性焦虑抑郁患者障碍随机分为观察组和对照组,每组各75例.观察组患者服用逍遥散,对照组患者服用氟哌噻吨美利曲辛片治疗4周,随访1个月,并采用汉密顿抑郁(HAMD)量表、汉密顿焦虑(HAMA)量表和中医证候量表进行疗效评定.结果 治疗4周后,观察组患者HAMD评定总有效率为86.3％、HAMA评定总有效率为79.4％,对照组HAMD评定总有效率为77.8％、HAMA评定总有效率为72.2％,差异均无统计学意义(均P?0.05),但观察组HAMD量表的焦虑/躯体化因子得分[(3.5±1.4)分]明显低于对照组[(4.6±1.3)分](P?0.01),睡眠障碍因子得分[(2.6±1.3)分]明显低于对照组[(3.3±1.4)分](P?0.01).观察组治疗2周、4周时,中医证候改善明显,与对照组比较差异有统计学意义(P?0.01).治疗结束后1个月,对照组HAMD、HAMA及其因子分均较治疗4周时升高,差异均有统计学意义(P?0.01);但是观察组HAMD、HAMA及其因子得分与治疗4周时比较,差异无统计学意义(P?0.05).结论 逍遥散和氟哌噻吨美利曲辛片对改善混合性焦虑抑郁的症状均有明显的效果,但逍遥散对患者焦虑、躯体化及睡眠障碍等方面的改善作用和远期效果优于氟哌噻吨美利曲辛片.

Objective:To understand the clinical application of folk medicine in our hospital from 2013 to 2015, summarize the commonly used folk medicines in our hospital, and analyze the rationality of their use in clinic considering the clinical characteristics of our hospital to guide the scientiifc use of folk medicine in the future.Methods:Taking deifned daily dose (DDD), DDDs (DDDs), and deifned daily cost (DDC) as the evaluation index, the use of the top 20 folk medicines in amount of money in our hospital during 2013-2015 were analyzed.Results:The top 20 folk medicines were mostly drugs for topical bone injury, encephalopathy and gastrointestinal diseases.The amount of money of the drugs remained stable for three years, and the amount of money and the number of patients synchronized well. Conclusion: Folk medicines are widely used in orthopedics,encephalopathy and spleen and stomach diseases, and their clinical application is basically reasonable.

Objective:In this study, we retrospectively analyzed the hospital records of in-patients with cerebral infarction in our hospital in 2013 in order to identify the point for the clinical pharmacists to provide pharmaceutical care for patients with cerebral infarction, and initially establish the model of individual pharmaceutical care for patients with cerebral infarction in our hospital.Methods:202 patients with cerebral infarction were selected from all medical records in 2013, and the information such as admission diagnosis and drug use were collected, and the usage amounts of drugs, DDDs and DUI were calculated by EXCEL to analyze the rationality of drug use.Results: The drug use for treating cerebral infarction in our hospital mainly included anticoagulant agents, anti-platelet agents and neuro-protective agents for the purpose of the treatment of cerebral infarction, and anti-hypertensive agents, hypoglycemic agents, and lipid regulating agents for the purpose of treating complications. Observed adverse reactions were few and patients had good compliance. Conclusion: The results showed that drug use for treating cerebral infarction in our hospital was normative. Through this study, clinical pharmacists understand the current situation of the treatment of cerebral infarction in our hospital and the existing problems, and targeted pharmaceutical service model has been initially established according to the clinical and the needs of patients. The ability of pharmacists to participate clinical drug treatment work has been improved in our hospital, thus laying a foundation for the high-quality pharmaceutical care.

目的观察心脑舒通胶囊治疗高黏血症的疗效。方法80例高黏血症患者,服用心脑舒通胶囊治疗28d,治疗前后进行中医证候疗效评定,并观察治疗前后血液流变学指标、血小板计数、凝血酶原时间、部分凝血活酶时间及血脂变化。结果治疗前后全血黏度、血浆黏度、红细胞聚集性、血小板聚集率、血小板黏附率及血脂治疗前后比较有统计学意义(P<0.01),红细胞比容、红细胞变形性、纤维蛋白原、血小板计数、凝血酶原时间及部分凝血活酶时间变化均无统计学意义(P>0.05)。服用心脑舒通胶囊后中医证候改善明显。结论心脑舒通胶囊能显著抑制血小板黏附和聚集、降低血黏度,能明显改善患者中医证候。