Journal of Medical VirologyVolume 93, Issue 4 p. 1850-1851 LETTER TO THE EDITOR Human herpesvirus-6, -7, and Epstein-Barr virus reactivation in pityriasis rosea during COVID-19 Francesco Drago MD, Francesco Drago MD Dermatology Unit, Ospedale Policlinico San Martino, Genoa, Italy Section of Dermatology, Di. S. Sal, University of Genoa, Genoa, ItalySearch for more papers by this authorGiulia Ciccarese MD, PhD, Corresponding Author Giulia Ciccarese MD, PhD [email protected] orcid.org/0000-0001-8363-0195 Dermatology Unit, Ospedale Policlinico San Martino, Genoa, Italy Correspondence Giulia Ciccarese, MD, PhD, Dermatology Unit, Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132 Genova, Italy. Email: [email protected]Search for more papers by this authorAlfredo Rebora MD, Alfredo Rebora MD Section of Dermatology, Di. S. Sal, University of Genoa, Genoa, ItalySearch for more papers by this authorAurora Parodi MD, Aurora Parodi MD Dermatology Unit, Ospedale Policlinico San Martino, Genoa, Italy Section of Dermatology, Di. S. Sal, University of Genoa, Genoa, ItalySearch for more papers by this author Francesco Drago MD, Francesco Drago MD Dermatology Unit, Ospedale Policlinico San Martino, Genoa, Italy Section of Dermatology, Di. S. Sal, University of Genoa, Genoa, ItalySearch for more papers by this authorGiulia Ciccarese MD, PhD, Corresponding Author Giulia Ciccarese MD, PhD [email protected] orcid.org/0000-0001-8363-0195 Dermatology Unit, Ospedale Policlinico San Martino, Genoa, Italy Correspondence Giulia Ciccarese, MD, PhD, Dermatology Unit, Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132 Genova, Italy. Email: [email protected]Search for more papers by this authorAlfredo Rebora MD, Alfredo Rebora MD Section of Dermatology, Di. S. Sal, University of Genoa, Genoa, ItalySearch for more papers by this authorAurora Parodi MD, Aurora Parodi MD Dermatology Unit, Ospedale Policlinico San Martino, Genoa, Italy Section of Dermatology, Di. S. Sal, University of Genoa, Genoa, ItalySearch for more papers by this author First published: 24 September 2020 https://doi.org/10.1002/jmv.26549Citations: 79Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. REFERENCES 1Galván Casas C, Català A, Carretero Hernández G, et al. Classification of the cutaneous manifestations of COVID-19: a rapid prospective nationwide consensus study in Spain with 375 cases. Br J Dermatol. 2020; 183(1): 71-77. https://doi.org/10.1111/bjd.19163 10.1111/bjd.19163 CASPubMedWeb of Science®Google Scholar 2Martín Enguix D, Salazar Nievas MDC, Martín Romero DT. Pityriasis rosea Gibert type rash in an asymptomatic patient that tested positive for COVID-19. Med Clín. 2020. https://doi.org/10.1016/j.medcle.2020.05.017 PubMedWeb of Science®Google Scholar 3Ehsani AH, Nasimi M, Bigdelo Z. Pityriasis rosea as a cutaneous manifestation of COVID-19 infection. J Eur Acad Dermatol Venereol. 2020; 34(9): e436-e437. https://doi.org/10.1111/jdv.16579 10.1111/jdv.16579 CASPubMedWeb of Science®Google Scholar 4Watanabe T, Kawamura T, Aquilino EA, et al. Pityriasis rosea is associated with systemic active infection with both human herpesvirus-7 and human herpesvirus-6. J Invest Dermatol. 2002; 119(4): 793-797. https://doi.org/10.1046/j.1523-1747.2002.00200.x 10.1046/j.1523-1747.2002.00200.x CASPubMedWeb of Science®Google Scholar 5Nowak DM, Sordillo EM, Gitman RM, Paniz Mondolfi AE. Co-infection in SARS-CoV-2 infected patients: where are influenza virus and rhinovirus/enterovirus? J Med Virol. 2020; 92(10): 1699-1700. https://doi.org/10.1002/jmv.25953 10.1002/jmv.25953 CASPubMedWeb of Science®Google Scholar 6Ciccarese G, Parodi A, Drago F. SARS-COV-2 as possible inducer of viral reactivations. Dermatol Ther. 2020:e13878. https://doi.org/10.1111/dth.13878 PubMedWeb of Science®Google Scholar 7Flamand L, Stefanescu I, Ablashi DV, Menezes J. Activation of the Epstein-Barr virus replicative cycle by human herpesvirus 6. J Virol. 1993; 67: 6768-6777. https://doi.org/10.1128/JVI.67.11.6768-6777.1993 10.1128/JVI.67.11.6768-6777.1993 CASPubMedWeb of Science®Google Scholar 8Drago F, Rebora A. Viral reactivation and skin eruptions. Dermatology. 2003; 207: 1-2. 10.1159/000070931 CASPubMedWeb of Science®Google Scholar 9Sanchez A, Sohier P, Benghanem S, et al. Digitate papulosquamous eruption associated with severe acute respiratory syndrome coronavirus 2 infection. JAMA Dermatol. 2020; 156: 819-820. https://doi.org/10.1001/jamadermatol.2020.1704 10.1001/jamadermatol.2020.1704 PubMedWeb of Science®Google Scholar 10Gianotti R, Veraldi S, Recalcati S, et al. Cutaneous clinico-pathological findings in three COVID-19-positive patients observed in the metropolitan area of Milan, Italy. Acta Derm Venereol. 2020; 100(8):adv00124. https://doi.org/10.2340/00015555-3490 10.2340/00015555-3490 CASPubMedWeb of Science®Google Scholar 11Perrella A, Trama U, Bernardi FF, et al. Editorial–COVID-19, more than a viral pneumonia. Eur Rev Med Pharmacol Sci. 2020; 24(9): 5183-5185. https://doi.org/10.26355/eurrev-202005-21216 CASPubMedWeb of Science®Google Scholar 12Lai CC, Wang CY, Hsueh PR. Co-infections among patients with COVID-19: the need for combination therapy with non-anti-SARS-CoV-2 agents? J Microbiol Immunol Infect. 2020; 53(4): 505-512. https://doi.org/10.1016/j.jmii.2020.05.013 10.1016/j.jmii.2020.05.013 CASPubMedGoogle Scholar Citing Literature Volume93, Issue4Special Issue on New coronavirus (2019‐nCoV or SARS‐CoV‐2) and the outbreak of the respiratory illness (COVID‐19): Part‐XIApril 2021Pages 1850-1851 ReferencesRelatedInformation

BACKGROUND: Sexually transmitted infections (STIs) may impact on the patient's physical, psychological and sexual health and negatively influence their Quality of Life (QOL). Studies on this topic are scarce. This study aimed to assess the impact of STIs different from HIV on QOL, mood and sexual functioning in the patients attending our STIs center in comparison with patients affected by chronic inflammatory bowel diseases (IBD). METHODS: An anonymous questionnaire was provided. It included 3 validated questionnaires: the European Quality of Life 5 dimensions 5 levels; the Beck Depression Inventory-II for depressive symptoms; the Changes in Sexual Functioning Questionnaire (CSFQ) for sexual functioning. RESULTS: Seventy-three STIs patients and 51 IBD patients participated in the study. The mean EQ-5D-5L questionnaire scores were 86.72 in STIs and 89.21 in IBD patients, without statistically significant difference between the two groups. Symptoms of depression were more common and severe in STIs patients compared to IBD patients. Sexual functioning was slightly worse in STIs patients than in IBD patients. CONCLUSIONS: This is one the very few studies focused on the impact of STIs on patient's physical, psychological and sexual health. Physicians dealing with STIs should consider the possible psychological consequences of the disease.

Linked article: J.M. Neves et al. J Eur Acad Dermatol Venereol 2021; 35: 1712–1716. https://doi.org/10.1111/jdv.17302.

Globalization entails several medical problems along with economic and social complications. Migrations from other continents, increasing numbers of tourists worldwide, and importation of foreign parasites (eg, Aedes albopictus) have made diseases previously unknown in Europe a reality. The rapid spread of the coronavirus disease 2019 pandemic throughout the world is a warning that other epidemics are still possible. Most, if not all of these diseases, transmitted by viruses or bacteria, present with cutaneous symptoms and signs that are highly important for a speedy diagnosis, a fundamental concept for arresting the diseases and saving lives. Dermatologists play a significant role in delineating cutaneous and mucosal lesions that are often lumped together as dermatitis. We provide a review of many of these cutaneous and mucosal lesions that sometimes are forgotten or even ignored.

Journal of the European Academy of Dermatology and VenereologyVolume 35, Issue 12 p. e868-e870 Letter to the Editor Two cases of papulo-pustular rosacea-like eruptions following COVID-19 vaccinations G. Ciccarese, G. Ciccarese orcid.org/0000-0001-8363-0195 Dermatology Clinic, Ospedale Policlinico San Martino, Genoa, ItalySearch for more papers by this authorF. Drago, F. Drago Dermatology Clinic, Ospedale Policlinico San Martino, Genoa, Italy DI.S.Sal., Section of Dermatology, University of Genoa, Genoa, ItalySearch for more papers by this authorA. Rebora, A. Rebora DI.S.Sal., Section of Dermatology, University of Genoa, Genoa, ItalySearch for more papers by this authorA. Parodi, A. Parodi Dermatology Clinic, Ospedale Policlinico San Martino, Genoa, Italy DI.S.Sal., Section of Dermatology, University of Genoa, Genoa, ItalySearch for more papers by this author G. Ciccarese, G. Ciccarese orcid.org/0000-0001-8363-0195 Dermatology Clinic, Ospedale Policlinico San Martino, Genoa, ItalySearch for more papers by this authorF. Drago, F. Drago Dermatology Clinic, Ospedale Policlinico San Martino, Genoa, Italy DI.S.Sal., Section of Dermatology, University of Genoa, Genoa, ItalySearch for more papers by this authorA. Rebora, A. Rebora DI.S.Sal., Section of Dermatology, University of Genoa, Genoa, ItalySearch for more papers by this authorA. Parodi, A. Parodi Dermatology Clinic, Ospedale Policlinico San Martino, Genoa, Italy DI.S.Sal., Section of Dermatology, University of Genoa, Genoa, ItalySearch for more papers by this author First published: 20 August 2021 https://doi.org/10.1111/jdv.17615Citations: 6 *Correspondence: G. Ciccarese. E-mail: [email protected] Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Conflict of interest None. References 1Johnston MS, Galan A, Watsky KL, Little AJ. Delayed localized hypersensitivity reactions to the moderna COVID-19 vaccine: a case series. JAMA Dermatol 2021; 12: e211214. Google Scholar 2Farinazzo E, Ponis G, Zelin E et al. Cutaneous adverse reactions after m-RNA COVID-19 vaccine: early reports from North-East Italy. J Eur Acad Dermatol Venereol 2021; 35: 548–551. 10.1111/jdv.17343 CASPubMedWeb of Science®Google Scholar 3Ciccarese G, Parodi A, Rebora A, Drago F. The usefulness of investigating the possible underlying conditions in rosacea. J Eur Acad Dermatol Venereol 2018; 32: e88–e89. 10.1111/jdv.14547 CASPubMedWeb of Science®Google Scholar 4Kiyohara Y, Yamazaki N, Kishi A. Erlotinib-related skin toxicities: treatment strategies in patients with metastatic non-small cell lung cancer. J Am Acad Dermatol 2013; 69: 463–472. 10.1016/j.jaad.2013.02.025 CASPubMedWeb of Science®Google Scholar 5Russi EG, Moretto F, Rampino M et al. Acute skin toxicity management in head and neck cancer patients treated with radiotherapy and chemotherapy or EGFR inhibitors: Literature review and consensus. Crit Rev Oncol Hematol 2015; 96: 167–182. 10.1016/j.critrevonc.2015.06.001 PubMedWeb of Science®Google Scholar 6Ewer KJ, Barrett JR, Belij-Rammerstorfer S et al. T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial. Nat Med 2021; 27: 270–278. 10.1038/s41591-020-01194-5 CASPubMedWeb of Science®Google Scholar 7Sahin U, Muik A, Derhovanessian E et al. COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses. Nature 2020; 586: 594–599. 10.1038/s41586-020-2814-7 CASPubMedWeb of Science®Google Scholar 8Marson JW, Baldwin HE. Rosacea: a wholistic review and update from pathogenesis to diagnosis and therapy. Int J Dermatol 2020; 59: e175–e182. 10.1111/ijd.14757 PubMedWeb of Science®Google Scholar 9Hayran Y, Şen O, Fırat Oğuz E et al. Serum IL-17 levels in patients with rosacea. J Cosmet Dermatol 2021; 20. Online ahead of print. PubMedWeb of Science®Google Scholar 10Hayran Y, Lay I, Mocan MC, Bozduman T, Ersoy-Evans S. Vascular endothelial growth factor gene polymorphisms in patients with rosacea: A case-control study. J Am Acad Dermatol 2019; 81: 348–354. 10.1016/j.jaad.2019.03.055 CASPubMedWeb of Science®Google Scholar Citing Literature Volume35, Issue12December 2021Pages e868-e870 This article also appears in:JEADV COVID-19 articles ReferencesRelatedInformation

After the incidental observation of an almost complete resolution of maculopapular eruption in a patient having simultaneously secondary syphilis and trichomonas vaginalis infection, we extended the treatment with tinidazole (500 mg 4 times daily for 7 days) to 10 other early syphilis patients before the start of the conventional penicillin treatment. All patients showed marked improvement of their lesions in a few days. After the introduction of the conventional penicillin regimen, the lesions further improved and VDRL titers declined at least 4-fold within 6 months in all patients. Tinidazole is a 5-nitroimidazole derivative as well as metronidazole but with a longer plasma half-life. It is activated intracellularly by bacterial/parasitic enzymes to a redox cytotoxic intermediate that damages large protein molecules and inhibits repair and transcription of DNA affecting also the cell wall. With this action, tinidazole might also have a synergic action with penicillin and doxycycline, facilitating the entry of such drugs. It is possible that tinidazole has the same bactericidal action on spirochetes other than Borrelia, such as Treponema pallidum, explaining its rapid therapeutic action on the lesions of early syphilis. Whether this action could be confirmed by studies on larger series of patients, tinidazole might be considered in case of allergy to penicillin or other antibiotics usually prescribed in syphilis.

common bacteria reside in the intestine of healthy people and can spread to the surrounding organs causing infections regardless of sexual transmission. On the other hand, common bacteria urinary tract infections (UTIs) can be favored by sexual intercourses. Type of sexual orientation, number of sexual partners, female anatomy, diabetes and obesity are risk factors for UTIs2 . A study about UTIs prevalence in women attending a STIs center disclosed a correlation with their sexual activity.

Data on the prevalence of sexually transmitted infections (STIs) and risk factors among incarcerated people are few and data about STIs awareness among inmates are even lacking. This study aimed to assess prevalence of STIs, risky behaviours and STIs level of knowledge in male inmates of the Casa Circondariale-Genova Marassi, the main penitentiary in Genoa, Italy. Between January and June 2019, 662 inmate medical records were retrospectively examined to obtain clinical and laboratory data about STIs. To investigate the inmate level of knowledge of STIs and their risky behaviours, 111consenting participants answered, anonymously, a written questionnaire. One hundred and twenty-two patients had at least one infectious disease when entered the prison: HIV (1.8%), HBV (2.7%), HCV (12.5%) and syphilis (1.3%). When asked to select from a list of diseases which ones they thought to be sexually transmitted, only 12% of the inmates answered correctly; most of them ignored which body fluids are at risk for HIV transmission, which STIs can induce tumors and if any vaccination exists to prevent STIs. Substance abuse was common among inmates that frequently exchanged needles for injecting drugs. To reduce the STIs incidence, it is necessary to target high-risk populations: everyone entering a prison should be offered a systematic screening of all STIs, including those currently neglected. Since STIs knowledge among inmates is poor and risky behaviours are diffuse, informative interventions in prison may provide an opportunity to educate such a high-risk population.

The progressive reduction of the number of terminal hairs and the simultaneous increase in the number of vellus hairs (hair miniaturization) are the current explanation of human baldness. In a 2.5-year study on 43 male subjects with androgenetic alopecia (AGA), we found that oral finasteride augmented the total number of hairs by 55%, but failed to decrease the prevalence of vellus hairs. While our data may explain why, in AGA, hairs become progressively softer and combable, they cannot explain why areas of hair rarefaction develop. We propose that the longer duration and higher frequency of kenogen hairs are the real mechanism through which the scalp hairs rarefy.

Any infectious illness presenting with an eruption in a pregnant patient may be associated with an increased risk of fetal loss. The viruses that can infect the placenta during maternal infection and can be transmitted to the fetus and cause congenital disease include the rubella virus, the measles virus, the varicella zoster virus, parvovirus B19, human cytomegalovirus, arboviruses, and hepatitis E virus type 1. In addition, some bacteria responsible for exanthematous diseases, like Treponema pallidum, can be transmitted during pregnancy from the mother to the fetus and cause fetal loss. All these infectious agents can cause typical and/or atypical exanthems whose etiologic diagnosis is sometimes difficult but important to determine, especially in pregnant women because of the potential risk to the fetus. In the last 20 years, we have extensively studied pityriasis rosea from the clinical and laboratory perspectives, demonstrating the pathogenic role of human herpesvirus (HHV)-6 and -7. We synthesize the available evidence that PR may be associated with active HHV-6/7 infection and therefore with complications during pregnancy and fetal loss. We have also summarized the emerging infectious illnesses of dermatologic interest that may represent life-threatening health conditions for the fetus: measles, rubella, arbovirus infection, and syphilis.

BACKGROUND:Recently, Herpes simplex virus (HSV)-1 seroprevalence declined among adolescents, rendering young people lacking HSV-1 antibodies more susceptible to genital HSV-1 acquisition, if sexually exposed. The aim of the present study was to identify the possible risk factors for the development of HSV-1 related Herpes genitalis (HG).METHODS:From January 2012 to December 2015, patients with HG attending three Sexually Transmitted Infections Units in Northern Italy were recruited. A genital swab on the lesions for the search of HSV-1/2 DNA through real time polymerase chain reaction (PCR) and a serum sample for HSV-1/2 specific serology were performed. Moreover, patients were asked whether they had personal history of herpes labialis (HL). Patients with PCR proved HSV-1 HG were included as cases; asymptomatic subjects attending STI Units for a blood check were recruited as controls and were checked for HSV-1/2 serology.RESULTS:The study included 141 cases and 70 controls. Specific HSV-1 antibodies were found in 34.7% of the cases and 67% of the controls. History of recurrent herpes labialis (RHL) was found in 4% of the cases and 31% of the controls. The occurrence of RHL in HSV-1 seropositive patients resulted lower in the case group compared to the control group.CONCLUSIONS:We can speculate about a protective role for RHL against the clinical appearance of HSV-1 HG. The clinical usefulness of our study involved especially the counselling in serodiscordant couples. The presence of HSV-1 antibodies in asymptomatic sexual partners does appear protective for HG manifestation only in presence of RHL history.

Journal of the European Academy of Dermatology and VenereologyVolume 33, Issue 4 p. e150-e151 Letter to the Editor Prevalence and persistence of oral HPV infection in Italy F. Drago, F. Drago DISSAL, Section of Dermatology, Ospedale Policlinico San Martino, Largo Rosanna Benzi, 10, Genoa, 16132 ItalyThese authors contributed equally to this work.Search for more papers by this authorA. Herzum, Corresponding Author A. Herzum astridherzum@yahoo.it orcid.org/0000-0001-6373-8801 DISSAL, Section of Dermatology, Ospedale Policlinico San Martino, Largo Rosanna Benzi, 10, Genoa, 16132 ItalyThese authors contributed equally to this work.Correspondence: A. Herzum. E-mail: astridherzum@yahoo.itSearch for more papers by this authorG. Ciccarese, G. Ciccarese DISSAL, Section of Dermatology, Ospedale Policlinico San Martino, Largo Rosanna Benzi, 10, Genoa, 16132 ItalySearch for more papers by this authorM. Dezzana, M. Dezzana Pathology Unit E.O. Galliera Hospitals, Via Mura delle Cappuccine, 14, Genova, 16128 ItalySearch for more papers by this authorA. Pastorino, A. Pastorino Pathology Unit E.O. Galliera Hospitals, Via Mura delle Cappuccine, 14, Genova, 16128 ItalySearch for more papers by this authorS. Casazza, S. Casazza Pathology Unit E.O. Galliera Hospitals, Via Mura delle Cappuccine, 14, Genova, 16128 ItalySearch for more papers by this authorP. Nozza, P. Nozza Pathology Unit E.O. Galliera Hospitals, Via Mura delle Cappuccine, 14, Genova, 16128 ItalySearch for more papers by this authorA. Rebora, A. Rebora DISSAL, Section of Dermatology, Ospedale Policlinico San Martino, Largo Rosanna Benzi, 10, Genoa, 16132 ItalySearch for more papers by this authorA. Parodi, A. Parodi DISSAL, Section of Dermatology, Ospedale Policlinico San Martino, Largo Rosanna Benzi, 10, Genoa, 16132 ItalySearch for more papers by this author F. Drago, F. Drago DISSAL, Section of Dermatology, Ospedale Policlinico San Martino, Largo Rosanna Benzi, 10, Genoa, 16132 ItalyThese authors contributed equally to this work.Search for more papers by this authorA. Herzum, Corresponding Author A. Herzum astridherzum@yahoo.it orcid.org/0000-0001-6373-8801 DISSAL, Section of Dermatology, Ospedale Policlinico San Martino, Largo Rosanna Benzi, 10, Genoa, 16132 ItalyThese authors contributed equally to this work.Correspondence: A. Herzum. E-mail: astridherzum@yahoo.itSearch for more papers by this authorG. Ciccarese, G. Ciccarese DISSAL, Section of Dermatology, Ospedale Policlinico San Martino, Largo Rosanna Benzi, 10, Genoa, 16132 ItalySearch for more papers by this authorM. Dezzana, M. Dezzana Pathology Unit E.O. Galliera Hospitals, Via Mura delle Cappuccine, 14, Genova, 16128 ItalySearch for more papers by this authorA. Pastorino, A. Pastorino Pathology Unit E.O. Galliera Hospitals, Via Mura delle Cappuccine, 14, Genova, 16128 ItalySearch for more papers by this authorS. Casazza, S. Casazza Pathology Unit E.O. Galliera Hospitals, Via Mura delle Cappuccine, 14, Genova, 16128 ItalySearch for more papers by this authorP. Nozza, P. Nozza Pathology Unit E.O. Galliera Hospitals, Via Mura delle Cappuccine, 14, Genova, 16128 ItalySearch for more papers by this authorA. Rebora, A. Rebora DISSAL, Section of Dermatology, Ospedale Policlinico San Martino, Largo Rosanna Benzi, 10, Genoa, 16132 ItalySearch for more papers by this authorA. Parodi, A. Parodi DISSAL, Section of Dermatology, Ospedale Policlinico San Martino, Largo Rosanna Benzi, 10, Genoa, 16132 ItalySearch for more papers by this author First published: 05 December 2018 https://doi.org/10.1111/jdv.15380Citations: 2 Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article.Citing Literature Volume33, Issue4April 2019Pages e150-e151 RelatedInformation

Excessive hair shedding is a common and alarming phenomenon, usually complained about by women. The disorder, named telogen effluvium (TE), bears several problems which are discussed in this essay. They are as follows: 1) how profuse a hair loss must be for TE to be diagnosed; 2) its heterogeneity that needs to be properly classified; 3) its distinction from androgenetic alopecia (AGA) with which it is often associated; 4) its main symptom, trichodynia, which is unclear how frequent and how diagnostic could be; 5) why histopathology has been reported to be nonspecific; and 6) its management, from diagnosis to treatment. A common mistake of the dermatologist is to minimize the complaint. Instead, the disorder may have a profound impact on the patients' mind and would require attention, time, and empathy.

Herpes zoster (HZ) is typically characterized by pain involving the area of vesicular eruption. Several patients, however, complain of unilateral radicular pain without rash (zoster sine herpete [ZSH]). To evaluate whether the severity and duration of pain and the use of analgesics are greater in ZSH patients than in typical HZ with rash, 16 consecutive patients with acute unilateral pain, without vesicular eruption (ZSH), were compared with 16 controls suffering from typical HZ eruption. Only patients with laboratory evidence of varicella‐zoster virus (VZV) reactivation were selected. Serum samples were obtained from all patients at their initial visit and 1 and 2 months later. Monthly, the administered therapies and the average pain score (visual analog scale [VAS] score) were recorded. VZV DNA persisted statistically higher in ZSH sera than HZ sera 1 month after onset (P = 0.0007). ZSH patients averaged greater pain than HZ patients, scoring VAS 76.88 and 66.88 ( P = 0.0012), respectively. ZSH patients used significantly more opioid therapy than HZ patients ( P = 0.0449; OR, 9.00). This is the first study comparing pain in ZSH and HZ patients: greater severity and duration of pain and more opioid use was detected in patients with ZSH.

Journal of the European Academy of Dermatology and VenereologyVolume 33, Issue 1 p. e36-e38 Letter to the Editor Dermatological infections in organ transplant recipients: a retrospective study on 222 patients G. Ciccarese, Corresponding Author G. Ciccarese giuliaciccarese@libero.it DISSAL Section of Dermatology, University of Genoa, Genoa, ItalyCorrespondence: G. Ciccarese. E-mail: giuliaciccarese@libero.itSearch for more papers by this authorI. Trave, I. Trave DISSAL Section of Dermatology, University of Genoa, Genoa, ItalySearch for more papers by this authorA. Herzum, A. Herzum DISSAL Section of Dermatology, University of Genoa, Genoa, ItalySearch for more papers by this authorL. Gariazzo, L. Gariazzo DISSAL Section of Dermatology, University of Genoa, Genoa, ItalySearch for more papers by this authorE. Cozzani, E. Cozzani DISSAL Section of Dermatology, University of Genoa, Genoa, ItalySearch for more papers by this authorA. Rebora, A. Rebora DISSAL Section of Dermatology, University of Genoa, Genoa, ItalySearch for more papers by this authorA. Parodi, A. Parodi DISSAL Section of Dermatology, University of Genoa, Genoa, ItalySearch for more papers by this authorF. Drago, F. Drago DISSAL Section of Dermatology, University of Genoa, Genoa, ItalySearch for more papers by this author G. Ciccarese, Corresponding Author G. Ciccarese giuliaciccarese@libero.it DISSAL Section of Dermatology, University of Genoa, Genoa, ItalyCorrespondence: G. Ciccarese. E-mail: giuliaciccarese@libero.itSearch for more papers by this authorI. Trave, I. Trave DISSAL Section of Dermatology, University of Genoa, Genoa, ItalySearch for more papers by this authorA. Herzum, A. Herzum DISSAL Section of Dermatology, University of Genoa, Genoa, ItalySearch for more papers by this authorL. Gariazzo, L. Gariazzo DISSAL Section of Dermatology, University of Genoa, Genoa, ItalySearch for more papers by this authorE. Cozzani, E. Cozzani DISSAL Section of Dermatology, University of Genoa, Genoa, ItalySearch for more papers by this authorA. Rebora, A. Rebora DISSAL Section of Dermatology, University of Genoa, Genoa, ItalySearch for more papers by this authorA. Parodi, A. Parodi DISSAL Section of Dermatology, University of Genoa, Genoa, ItalySearch for more papers by this authorF. Drago, F. Drago DISSAL Section of Dermatology, University of Genoa, Genoa, ItalySearch for more papers by this author First published: 28 June 2018 https://doi.org/10.1111/jdv.15153Citations: 1Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article.Citing Literature Volume33, Issue1January 2019Pages e36-e38 RelatedInformation

Journal of the European Academy of Dermatology and VenereologyVolume 32, Issue 3 p. e88-e89 Letter to the Editor The usefulness of investigating the possible underlying conditions in rosacea G. Ciccarese, Corresponding Author G. Ciccarese giuliaciccarese@libero.it Department of Dermatology, IRCCS San Martino IST, DISSAL, Genoa, ItalyCorrespondence: G. Ciccarese. E-mail: giuliaciccarese@libero.itSearch for more papers by this authorA. Parodi, A. Parodi Department of Dermatology, IRCCS San Martino IST, DISSAL, Genoa, ItalySearch for more papers by this authorA. Rebora, A. Rebora Department of Dermatology, IRCCS San Martino IST, DISSAL, Genoa, ItalySearch for more papers by this authorF. Drago, F. Drago Department of Dermatology, IRCCS San Martino IST, DISSAL, Genoa, ItalySearch for more papers by this author G. Ciccarese, Corresponding Author G. Ciccarese giuliaciccarese@libero.it Department of Dermatology, IRCCS San Martino IST, DISSAL, Genoa, ItalyCorrespondence: G. Ciccarese. E-mail: giuliaciccarese@libero.itSearch for more papers by this authorA. Parodi, A. Parodi Department of Dermatology, IRCCS San Martino IST, DISSAL, Genoa, ItalySearch for more papers by this authorA. Rebora, A. Rebora Department of Dermatology, IRCCS San Martino IST, DISSAL, Genoa, ItalySearch for more papers by this authorF. Drago, F. Drago Department of Dermatology, IRCCS San Martino IST, DISSAL, Genoa, ItalySearch for more papers by this author First published: 28 August 2017 https://doi.org/10.1111/jdv.14547Citations: 4Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article.Citing Literature Volume32, Issue3March 2018Pages e88-e89 RelatedInformation

Background: Pityriasis rosea (PR) is a self-limiting exanthematous disease associated with human herpesvirus (HHV)-6 and/or HHV-7 reactivation. In pregnant women, PR may be associated with pregnancy complications. Objective: To determine relevant risk factors in the development of negative pregnancy outcome in PR. Methods: Between 2005 and 2017 at the Department of Dermatology, University of Genoa, we recruited 76 women who developed PR during pregnancy. In 60 patients without known risk factors for intrauterine fetal death (30 with pregnancy complications and 30 without) we analyzed the pregnancy week of PR onset, presence of enanthem and of constitutional symptoms, PR body surface area involvement, age, and in 50 patients (20 with pregnancy complications and 30 without), the viral load of HHV-6 and HHV-7 (copies/mL). Results: In logistic regression analysis, early onset of PR (p = 0.0017) and enanthem (p = 0.0392) proved to be significantly associated with pregnancy complications. HHV-6 viral load (copies/mL) (p < 0.0001), constitutional symptoms (p < 0.001), and PR body surface area involvement (p < 0.004) were also significantly associated with pregnancy complications. Conclusion: The onset of PR before week 15 and enanthem may be considered major risk factors that should alarm the dermatologist. Constitutional symptoms and involvement of > 50% of the body area may be considered minor risk factors.