With the changment of life style and dietary structure, hyperlipidemia gradually becomes the third cause of sever acute pancreatitis. At present, literatures about hyperlipidemic sever acute pancreatitis (HL-SAP) are almost introductions of single treatment or case reports. This article gives an overview of the research progress in HL-SAP.

<正> 急性胰腺炎(AP)作为消化科常见急症,是目前研究热点之一。高脂血症引起的 AP,称为"急性高脂血症性胰腺炎(AHP)"。以往认为少见,但随着生活方式和环境的改变,发病率有上升趋势。目前有关其发病特点研究较少,本研究通过分析 AHP 患者的临床特征,旨在加强临床医生对该病的认识,提高诊治水平。

OBJECTIVE:Nature killer cell 2D (NKG2D) is an important activated cytokine that has been implicated in the inflammatory reaction and immune response. The function and the location of NKG2D gene show it is an ideal susceptibility gene to ulcerative colitis (UC). We evaluated the NKG2D gene polymorphisms in patients of Zhejiang province to determine whether the gene is associated with susceptibility to UC in Chinese Han population.METHODS:Blood samples were obtained from 110 patients with UC and 292 healthy controls in Zhejiang location. Genotyping for 2 common NKG2D (10676G/, 908A/) polymorphisms was carried out using polymerase chain sequence with specific primer.RESULTS:NKG2D was not associated with disease (908A allele frequency patients 19.1% vs controls 16.3%, P > 0.05). None of the patients with UC had 10676G heterozygous or homozygous variants. Similarly none of the health controls.CONCLUSIONS:The common variants in NKG2D are not associated with UC in the Chinese Han population. Research of larger sample's queue, analysis from different layer and DNA sequence will help to determine the function of NKG2D in the process of UC.

患者女,16岁,因"反复呕吐十余年"收住入院.入院体检:生命体征平稳,无发热,神志清,精神欠佳.皮肤巩膜无黄染,浅表淋巴结未触及肿大,心肺无特殊,腹平软,无压痛及反跳痛.肝脾肋下未及,移动性浊音阴性,肠鸣音8次/分,双下肢无水肿.入院后钡餐造影提示"十二指肠降部明显扩张,扭曲,直径约55 mm,内有较多食物残渣潴留,造影剂到达降部后管腔变窄,中间可见1个透亮弧线相隔,该线始终存在.注入气体后,气体停留在扩张的十二指肠降部和胃腔".考虑为十二指肠先天发育不良导致不全肠梗阻.行胃镜检查见十二指肠降段壶腹部上方环状隔膜,中间一裂隙样腔道,内镜无法通过,试行切开及气囊扩张,均未成功.故行外科手术,术中见十二指肠降部扩张明显,降部内可见1个横隔膜,近乳头处可见1个小孔,可容8号导尿管通过,予以隔膜切除.术后患者呕吐消失.

<正>患者女,59岁,因反复腹泻4年收住入院。大便呈黄色水样,10～20次／d,量中,无里急后重,时有阵发性脐周绞痛,无放射痛,自觉与饮食、体位无关。无发热、呕血及黑便,无恶心及呕吐。4年来体重下降20 kg。多次就诊于各大医院,自述曾行肠镜检查为“结肠炎”,服用多种调节菌群药物效果不佳。我院以“腹泻待查”收住入院。1年前有突发的腹痛、呕吐史,经腹部平片证实为不全性小肠梗阻,当时行肠

克罗恩病(CD)是一种常见的炎症性肠病,是环境因素作用于易感个体产生的肠道慢性非特异性炎症.其发病机制尚未完全明了.NOD2/CARD15是目前确认的第一个与CD相关的基因,通过介导凋亡,调节免疫等多种途径参与CD的发病.本文就NOD2/CARD15与CD的研究进展作一综述.

<正>腹膜假性黏液瘤(PMP)是一种腹膜继发性肿瘤,以腹腔弥漫性胶冻样积液伴腹膜表面和各网膜上黏液外分泌性细胞种植为特征性表现,临床少见,且临床表现缺乏特异性,易误诊。现总结本院1例患者的临床特点,并结合复习相关部分文献,以提高临床医师对该病的诊治水平。

基质金属蛋白酶是一组重要的蛋白分解酶,以能降解几乎所有的细胞外基质成分为主要特点,参与机体多种病理过程。炎症性肠病的病因和发病机制至今尚未完全明确,主要以持续的免疫反应通过一系列介质导致细胞外基质和粘膜的破坏为特点。MMP通过降解细胞外基质、介导细胞凋亡、影响血管生成等多种途径参与IBD及其并发症的发生、发展过程。加强对MMP的研究,有利于进一步深入探讨IBD的发病,对探索新的治疗方法具有重要意义。