AIM: To analyze the relationship of overweight and obesity with fatty liver, and explore the interaction of obesity and other risk factors in the incidence of fatty liver. METHODS: Totally 2 458 community residents were enrolled by means of stratified multistage cluster sampling between September 2002 and December 2004. According to 1:1 matched case-control study, this investigation adopted 425 cases diagnosed as fatty liver by B ultrasound and 425 controls matched by sex, age and inhabitancy. They aging over 18 years all received the personal interview and physical examination. RESULTS: All 850 subjects were involved in the result analysis. The risks of the incidence of fatty liver in overweight and obesity group were significantly higher than that in normal body weight group (OR =4.07, OR 95%CI =2.99-5.54). The odds ratio (OR ) increased with the body mass index, showing the clear dose-response relationship (Tendency χ 2=104.25, P < 0.000 1). The disease risk of abdominal obesity persons with abnormal waist hip ratio was higher than those without abdominal obesity. Interaction analysis suggested that obesity plus drinking habit could significantly increase the risk of fatty liver. Its relative excess risk of interaction was 8.16, and its attributable proportion of interaction was 0.576 7. CONCLUSION: There is a close relationship of overweight and obesity with the incidence of fatty liver, and a significantly synergistic interaction effect between obesity and drinking habit in developing fatty liver. The measurement to control the body weight is essential for decreasing the prevalence rate of fatty liver.

Objective:To investigate the effects of common inhibitors of the antioxidation system and vitamin C on the measurement of hemoglobin (Hb).Methods:Hemolyzed rabbit red blood cell was used as the sample.The interferences of common inhibitors of the antioxidation system on assay of Hb by its absorbance at 540nm,alkalinized Hb by absorbance at 575nm,the azide-Hb complex by absorbance at 542nm were compared.Results:Vitamin C and the inhibitors of superoxide dismutase,catalase exhibited larger interferences with direct assay of Hb by absorbance at 540 nm and the assay of azide-Hb,and inhibitor of GSH and GSH peroxidase showed smaller effects.The assay of alkalinized Hb exhibited the strongest resistance to all these chemicals.Conclusion:The assay of alkalinized Hb shows the strongest resistance to common chemicals used to investigate the mechanism of peroxidative damage and can be applicable to the study of the mechanism of vitamin C-induced hemolysis.

肾素-血管紧张素系统(RAS)在调节人体血压及电解质/血容量稳态方面起重要作用.近年来发现,机体除有经典的循环RAS外,很多组织,例如血管壁、心脏、中枢神经、肾脏及肾上腺均有RAS各成分的mRNA表达,并有血管紧张素Ⅱ(AngⅡ)受体存在.因此,组织中RAS自成系统,在高血压形成中可能具有更大的作用[1].AngⅡ是RAS中最重要的成分,是已知内源性升压物质中作用最强的激素之一.AngⅡ必须通过受体发挥作用,其受体有四种亚型,即AT1、AT2、AT3、AT4[2],以AT1和AT2为主,存在于人类的大多数组织中,但有不同的功能[3],AT3和AT4亚型在兔和家禽组织中已鉴定出,但对人类似乎无任何相关[4].AngⅡ的绝大多数生物学作用是由AT1受体(AT1R)介导的,Ⅰ型血管紧张素Ⅱ受体基因(AT1R基因)主要分布于血管平滑肌细胞上[3],因此,AT1R基因是高血压(EH)研究的重要基因,而且,亦提示对其准确检测必要性,以满足研究和临床的需要.

糖尿病是一组由遗传和环境因素相互作用而引起的临床综合症.近年来,糖尿病发病率上升很快,防治糖尿病已成为科学工作者的一个重要课题.合适的糖尿病模型无疑可对人类糖尿病研究提供重要的手段.