Objective To investigate the functional esophageal dismotility in patients with gastroesophageal reflux disease(GERD) by simultaneous high frequency intraluminal ultrasonography(HFIUS) and esophageal manometry,and evaluate the correlation between the peak pressure and the peak muscle thickness of the esophagus.Besides,to identify the potential efficacy and feasibility of the HFIUS for evaluating the functional gastrointestinal diseases(FGIDs).Methods Ten GERD patients and 5 healthy controls were enrolled into this study.High-frequency ultrasonic probe and esophageal manometry catheter were simultaneous administrated.The cross sectional image of esophageal motion was recorded by HFIUS and was analyzed by the contractility index (CI)of the longitudinal smooth muscle(LSM)and circular smooth muscle(CSM),the duration of the contraction (DC)and the maximum cross section area(CSA)during distension;In addition,esophageal peak pressure during wet-swaltow was measured by manometry.Results Tile contractility index of the LSM and CSM of esophagus at 5 cm,10 cm,1 5 cm and 20 em proximal to the LES was significantly lower in patients with GERD than that of controls(P＜0.05).The duration of the contraction was longer in patients with GERD.But there was no siginificant difference of the maximum CSA during distension between GERD patients and normal controls(P＞0.05).However,the simultaneous manometry only demonstrated nonspecific esophageal motility disorder on 6 of 10 GERD patients.And there was positive correlation between the peak pressure and the peak muscle thickness at all sites along the axis of the esophagus,revealed the pressure was increasing along with the thickening of the esophageal muscle layers(r=0.552-0.736).Conclusions Functional esophageal dismotility played an important role in the pathogenesis of GERD.Meanwhile,there was positive correlation between the esophageal pressure and the muscle layer thickness of the esophagus.HFIUS can detect the minor changes of the layer structure of the esophagus and is a potentially useful imaging modality for evaluating esophageal dismotility as well as FGIDs.

<正>长期以来受小肠解剖位置等影响,小肠的内镜探查受到局限,EUS作为一种成熟的技术已经被广泛运用于除小肠以外的其他消化道疾病的检查。随着双气囊小肠镜(DBE)的问世和应用[1,2],小肠腔内超声(ISUS)探

功能性胃肠病(FGIDs)是消化系统较常见的疾病.主要为胃肠道的运动与分泌功能失调及感觉异常,而无器质性病理改变.临床常主要表现为腹痛、腹胀、恶心、早饱、呕吐、腹泻及排便困难等症状,也可伴有其它功能性症状.长期以来,由于无法获得客观的FGIDs依据,临床医生对FGIDs的诊断受到限制.近年来,随着相关技术设备的不断发展,使研究者对胃肠运动功能方面的检查有了很大提高,其中影像学检查起着重要的作用.以下就常规的影像学检查方法,如放射学检查、核素显像等,以及近年来新用到临床的技术,如腔内超声和脑部显像等作一综述.

炎症性肠病(inflammatory bowel disease,IBD)包括溃疡性结肠炎(ulcerative colitis,UC)和克罗恩病(Crohn's disease,CD),是一类病因尚未明确的肠道非特异性炎症.目前治疗主要采用5-氨基水杨酸、糖皮质激素及免疫抑制剂等.