OBJECTIVE:This study aimed to compare the intraoperative and postoperative outcomes of laparoscopic intraperitoneal onlay mesh repair (IPOM) and transabdominal preperitoneal repair (TAPP) for adult umbilical hernia and to provide clinical evidence for procedure selection. METHODS:We retrospectively reviewed adult patients with umbilical hernia who underwent laparoscopic IPOM or TAPP at a single tertiary referral center between July 2021 and July 2024. Baseline characteristics, operative variables, postoperative pain scores, and postoperative complications were compared between the two groups. RESULTS:A total of 69 patients were included, including 39 in the IPOM group and 30 in the TAPP group. Baseline characteristics were comparable between groups. The mean operative time was significantly longer in the TAPP group than in the IPOM group. However, postoperative VAS pain scores on the day of surgery and on postoperative days 1 and 7 were significantly lower in the TAPP group. No significant between-group differences were observed in intraoperative blood loss, length of hospital stay, postoperative complications, or recurrence during follow-up. CONCLUSION:Both laparoscopic IPOM and TAPP were safe and feasible for the treatment of adult umbilical hernia in this cohort. Although TAPP required a longer operative time, it was associated with lower short-term postoperative pain. No significant differences were observed in recurrence or complication rates. Larger prospective studies are needed to further clarify the comparative effectiveness of these two techniques.

BackgroundPostoperative complications (POCs) remain a major challenge in colorectal cancer (CRC) surgery. Easily accessible composite inflammatory indices derived from routine blood tests hold promise for preoperative risk stratification, but their comparative predictive value for POCs is unclear.MethodsWe conducted a two-center, retrospective study of 1331 patients who underwent radical CRC surgery between January 2021 to October 2025. The associations between preoperative composite inflammatory indices and the complications after surgery were evaluated using logistic regression. Their predictive discriminative performances were further assessed and compared using receiver operating characteristic (ROC) curve analysis, with the areas under the curve (AUC) compared by DeLong’s test.ResultsThe complication rate was 17.2% (229/1331). Patients with complications exhibited a significantly more pronounced pro-inflammatory and immunosuppressive preoperative profile across all indices (all P < 0.05). After adjustment, the systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), C-reactive protein-to-lymphocyte ratio (CLR), and systemic inflammation response index (SIRI) were identified as the strongest independent predictors, with the highest quartile (Q4) conferring substantially increased risks (OR for SII: 7.51; for NLR: 5.86; for CLR: 2.24; for SIRI: 2.99; all P-trend <0.05). ROC analysis confirmed SII as the best single predictor (AUC: 0.738). A combined model integrating SII, NLR, CLR, and SIRI achieved superior discriminative ability (AUC: 0.792), significantly outperforming any single index (all P < 0.05).ConclusionThe SII, NLR, CLR and SIRI, are strongly associated with the risk of POCs after CRC surgery. A model combining these four indices provides superior predictive performance.

Astrocyte senescence plays an essential role in CNS disorders. However, the understanding of astrocyte senescence and its regulatory targets in hepatic encephalopathy (HE) is limited. SGK1 was reported to regulate astrocyte senescence. Therefore, the current study aimed to investigate the role of SGK1 and astrocyte senescence in HE. The rat model of HE was established by common bile duct ligation. Adeno-associated virus (AAV) was used for astrocyte-specific knockdown of SGK1. The rats were also evaluated with behavioral tests. Primary rat astrocytes were used for in vitro validation. RNA-sequencing was used to further investigate the underlying mechanisms. SGK1 was significantly upregulated in HE, especially in astrocytes. Cellular senescence was enriched in the expression profiles of the brain from HE patients, when senescence-associated secretory phenotype (SASP) and mitochondrial dysfunction were also activated in astrocytes from the rat model of HE. Knockdown of astrocyte SGK1 ameliorated HE by alleviating cellular senescence and mitochondrial dysfunction, when the underlying mechanisms were tightly associated with interferon response. Alleviated astrocyte SASP by SGK1 knockdown further protected against neuroinflammation by suppressing microglia activation and pro-inflammatory polarization. The effects of SGK1 on astrocyte senescence were mediated by the IL-6/JAK2/STAT3 signaling pathway. SGK1 inhibition improved HE by ameliorating astrocyte senescence and mitochondrial dysfunction. SGK1 and the downstream IL-6/JAK2/STAT3 signaling pathway might be novel therapeutic targets for the treatment of HE.

To evaluate the feasibility, safety, and perioperative risk profile of the transabdominal preperitoneal (TAPP) approach in the surgical repair of upper abdominal ventral hernias. A retrospective cohort analysis was conducted on patients who underwent laparoscopic TAPP repair for upper abdominal ventral hernias at a single institution between March 2019 and July 2024. All patients were followed for at least 12 months postoperatively. Demographic data, hernia characteristics, operative details, and postoperative outcomes were analyzed. The TAPP procedure was successfully performed on 58 patients. Hernia localization included the M1 zone in 42 cases (72.4

Abdominal incisional hernia is a common complication following abdominal surgery. With disease progression, it can severely compromise patients’ quality of life and even threaten their lives, Among these, the surgical treatment of large incisional hernias remains both challenging and uncertain. As a standard surgical procedure for inguinal hernia, transabdominal preperitoneal (TAPP) repair has been adopted worldwide and achieved satisfactory results. Based on this experience, we applied the TAPP procedure to small- and medium-sized incisional hernias in the middle and lower abdomen and achieved promising outcomes. A retrospective statistical analysis was conducted on all patients with median incisional hernias treated with TAPP repair between January 2022 and December 2024. Demographic data, hernia classification, operation time, postoperative complications (such as seroma, hematoma, and incision site infection), readmission rate, and recurrence rate were analyzed. A total of 75 patients with incisional hernias underwent TAPP surgery. The operative time ranged from 92 to 141 min, with an average of 112.5 min. The visual analog scale score ranged from 2 to 5 points, with an average of 3.3 points. The postoperative hospital stay ranged from 2 to 4 days, averaging 2.7 days. Seromas occurred in eight patients but had no adverse effect on the final outcome; all cases resolved spontaneously during the 2-month follow-up. No hematoma, incision site infection, or chronic pain was reported. None of the patients required readmission within a short period, and no recurrence was observed during 4–30 months of follow-up. Cephalad approach TAPP repair is a safe and effective technique for the treatment of small- and medium-sized incisional hernias in the lower abdomen and warrants further investigation.

BACKGROUND Total laparoscopic distal gastrectomy (TLDG) is increasingly used for advanced gastric cancer, but its comprehensive outcomes vs open distal gastrectomy (ODG) require further validation. AIM To investigate the perioperative safety, postoperative recovery, and mid-term survival between TLDG and ODG for locally advanced gastric cancer. METHODS This retrospective study analyzed patients admitted from January 2020 to January 2022. Patients were divided into TLDG and ODG groups on the basis of surgical approach. Perioperative outcomes, postoperative recovery, tumor pathology, preoperative and postoperative day 1 and 5 blood tests, complications, and 3-year overall survival and recurrence-free survival rates were evaluated. RESULTS A total of 420 patients were included, with 213 in the TLDG group and 207 in the ODG group. The TLDG group had shorter incision lengths (4.51 +/- 0.52 cm vs 17.64 +/- 3.25 cm, P < 0.001) and less blood loss (152.44 +/- 26.55 mL vs 220.07 +/- 21.58 mL, P < 0.001). Postoperative recovery was faster in the TLDG group, with earlier mobilization (1.85 +/- 0.22 days vs 2.51 +/- 0.24 days, P < 0.001), flatus (2.92 +/- 0.24 days vs 3.52 +/- 0.21 days, P < 0.001), and lower visual analog scale scores (postoperative day 5: 26.54 +/- 4.20 vs 45.51 +/- 10.41, P < 0.001). Inflammation was reduced in the TLDG group (postoperative day 1 white blood cell: 11.18 +/- 2.11 & times; 109/L vs 11.81 +/- 2.22 & times; 109/L, P = 0.003). Complication rates were similar, but the ODG group had more grade I-II complications (17.39% vs 10.33%, P = 0.036). Three-year overall survival (90.61% vs 90.34%, P = 0.924) and recurrence-free survival (80.28% vs 81.16%, P = 0.820) showed no significant differences. CONCLUSION Compared with ODG, TLDG for locally advanced cancer offers superior short-term outcomes in terms of reduced trauma, accelerated functional recovery, and pain relief without compromising oncological efficacy or survival rates.

BACKGROUND Portal hypertension (PHT) is a life-threatening complication of chronic liver disease, necessitating reliable animal models that mimic its clinical heterogeneity. Classical mouse models like bile duct ligation (BDL) exhibit a low 4-week survival (35%), while carbon tetrachloride (CCl4) models have delayed pathogenesis, requiring ≥ 8 weeks for PHT development, limiting their efficiency. AIM To evaluate the 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) diet-induced mouse model as a biliary PHT model, comparing it to BDL and CCl4 models. METHODS Mice were assigned to DDC diet, BDL, or CCl4 groups. Assessments included portal pressure, histological examination of biliary fibrosis and hepatic stellate cell (HSC) activation (desmin expression), scanning electron microscopy for sinusoidal fenestrae and capillarization, endothelial nitric oxide synthase (eNOS) regulation (phosphorylated-eNOS/total eNOS ratio and total eNOS level), ductular reaction, inflammatory infiltration, and portosystemic shunting. Survival rates and operational feasibility (feed-based administration) were evaluated. RESULTS At 4 weeks, DDC induced portal pressure comparable to BDL and CCl4. The DDC model showed moderate biliary fibrosis (similar to BDL but less than CCl4) and greater HSC activation than the other two models. Sinusoidal fenestrae reduction and capillarization in DDC matched BDL and CCl4 models. DDC had decreased phosphorylated-eNOS/total eNOS ratio, while BDL and CCl4 models exhibited reduced total eNOS. DDC demonstrated robust ductular response, inflammation, and shunting, a hallmark of PHT. Survival was 100% (vs 35% BDL, 58.3%-66.6% CCl4), with simpler feed-based induction. CONCLUSION The DDC model offers strong biliary PHT relevance, high survival, and efficiency, making it a superior alternative to BDL and CCl4 models for biliary PHT research.

Portal hypertension (PHT), a life-threatening complication of chronic liver disease, is driven by increased hepatic vascular resistance, with liver sinusoidal endothelial cell (LSEC) dysfunction and impaired nitric oxide (NO) signaling as key contributors. This study synthesized spermidine-based carbon quantum dots (ST-CQDs) and investigated their therapeutic effects on PHT. ST-CQDs (average size 2.12 nm) exhibited good biocompatibility and effectively induced NO production in human immortalized LSECs (hiLSECs) by upregulating endothelial NO synthase (eNOS). In BDL and CCl4-induced PHT rat models, intravenous ST-CQDs reduced portal pressure by decreasing intrahepatic vascular resistance, reversed LSEC capillarization, inhibited hepatic stellate cell activation and liver fibrosis, and alleviated liver inflammation-without altering systemic hemodynamics or causing organ toxicity. In vitro, ST-CQDs reversed lipopolysaccharide-induced LSEC dysfunction by restoring eNOS expression and NO release. These findings demonstrate ST-CQDs as a potential therapeutic agent for PHT via targeting LSEC-derived NO signaling.

The Ruiyun procedure for hemorrhoids (RPH) and tissue-selecting therapy (TST) are two widely adopted minimally invasive techniques for treating Grade II-III hemorrhoids. This study aims to perform an exploratory comparison of the efficacy and safety of these two surgical techniques within a real-world clinical setting, thereby providing evidence to inform future prospective investigations. A retrospective analysis was conducted on 192 patients with Grade II-III hemorrhoids, comprising 80 patients who underwent RPH and 112 who underwent TST. The primary outcomes were the treatment effectiveness rate at one month and the recurrence rate within one year postoperatively. Secondary outcomes included operative time, intraoperative blood loss, time to return to normal activities, postoperative anal pain, complication rates, patient satisfaction, and PROM scores. The two groups were comparable in baseline characteristics. No significant differences were found in the overall clinical efficacy or the one-year recurrence rate between the groups (p > 0.05). However, the RPH group demonstrated significant advantages, including shorter operative time, reduced intraoperative blood loss, faster return to normal activities, lower anal pain scores on postoperative days 1 and 3, a lower incidence of fecal urgency and higher patient satisfaction (all p < 0.05). No significant intergroup differences were observed in terms of anal distension, postoperative bleeding, anorectal stenosis, PROM scores, or anal pain on postoperative day 7 (p > 0.05). Within the context of this retrospective study, RPH demonstrated efficacy and safety in the treatment of Grade II–III hemorrhoids. It exhibited favorable outcomes in reducing intraoperative blood loss, shortening operative time, minimizing postoperative complications, and facilitating a rapid return to normal activities. However, given the potential differences in baseline characteristics between the two patient groups, these observations cannot be directly interpreted as evidence of the superiority or inferiority of either technique. The observed differences in efficacy may be partially attributable to disparities in patient selection.

BACKGROUND AND AIMS:Lymphangiogenesis is enhanced during the development of liver cirrhosis and portal hypertension (PHT). However, hepatic lymphatic vascular system is understudied in liver cirrhosis and PHT. Hydrogen sulfide (H2S) and related compounds have potential prolymphangiogenic effects besides its previously reported vascular-protective effects. Therefore, we aimed to investigate the effects of endogenous H2S donor S-allyl-cysteine (SAC) on bile duct ligation (BDL)-induced liver cirrhosis and PHT. METHODS:BDL rats with cholestatic liver cirrhosis and PHT were orally administrated with SAC at 100 or 200 mg/kg/day, as well as DL-propargylglycine (PAG) or MAZ-51 injections. Hemodynamic parameters were determined, and subsequent evaluations of liver fibrosis, intrahepatic vascular resistance (IHVR) and lymphangiogensis were performed. Human lymphatic endothelial cells (hLECs) were used for in vitro verification of prolymphangiogenic effects of SAC. RESULTS:SAC treatment significantly decreased PP and promoted endogenous H2S production. Liver fibrosis and IHVR were also ameliorated. Hepatic and mesenteric lymphangiogenesis were enhanced in BDL rats and further promoted by SAC despite a significant downregulation of hepatic VEGF-C. Inhibition of H2S production by PAG significantly reduced lymphatic vessels, while inhibition of lymphangiogensis by MAZ-51 reversed the protective effects of SAC against PHT. SAC enhanced lymphangiogenic functions in vitro by promoting cellular H2S production and activating Akt phosphorylation without altering VEGF-C/D, which were reversed by PAG and MAZ-51. CONCLUSIONS:SAC significantly alleviated BDL-induced liver cirrhosis and PHT. Meanwhile, elevated H2S induced by SAC facilitated lymphangiogenesis via a VEGF-C-independent manner, which contributed to the alleviation of PHT.

Multimodal clinical reasoning in the field of gastrointestinal (GI) oncology necessitates the integrated interpretation of endoscopic imagery, radiological data, and biochemical markers. Despite the evident potential exhibited by Multimodal Large Language Models (MLLMs), they frequently encounter challenges such as context dilution and hallucination when confronted with intricate, heterogeneous medical histories. In order to address these limitations, a hierarchical Multi-Agent Framework is proposed, which emulates the collaborative workflow of a human Multidisciplinary Team (MDT). The system attained a composite expert evaluation score of 4.60/5.00, thereby demonstrating a substantial improvement over the monolithic baseline. It is noteworthy that the agent-based architecture yielded the most substantial enhancements in reasoning logic and medical accuracy. The findings indicate that mimetic, agent-based collaboration provides a scalable, interpretable, and clinically robust paradigm for automated decision support in oncology.

IntroductionFormononetin regulates intrahepatic fibrogenesis and macrophage polarization to improve portal pressure and liver function in rats with cirrhotic PHT through SMAD3, STAT1, STAT3 and GSK-3β signaling pathways, and modulates lymphangiogenesis through direct action and macrophage polarization-mediated indirect effects. Formononetin has the potential function of treating cirrhotic PHT.Background and aimsFormononetin (FN) has been reported to have anti-fibrotic effects in the kidneys and anti-M1 polarization effects on macrophages. Lymphangiogenesis is closely associated with macrophages, but its role in cirrhosis and portal hypertension (PHT) remains unclear. This study aims to explore the effects of FN on cirrhotic PHT and the disease-related intrahepatic lymphangiogenesis.MethodsIn vivo experiments, bile duct ligation (BDL) induced PHT models were conducted in rats, followed by a 4-week FN treatment (50 mg/kg/day) administered via gavage. Hemodynamics, liver fibrosis, infiltration and polarization of intrahepatic macrophages, as well as intrahepatic lymphangiogenesis, were observed. For in vitro experiments, hepatic stellate cells, macrophages and lymphatic endothelial cells were used to observe the multiple effects of FN.ResultsFN significantly ameliorated portal pressure in cirrhosis-induced PHT, improved liver function, and reduced liver fibrosis and hepatic stellate cell activation with decreased SMAD3 protein expression. The intrahepatic macrophage infiltration were markedly decreased, and M1-type macrophage polarization was suppressed by FN, accompanied by inhibition of STAT1, STAT3 and GSK-3β signaling pathways. In PHT models, FN reduced VEGF-C and VEGF-D levels in both the liver and blood, inhibiting intrahepatic lymphangiogenesis in portal area. In vitro, high-dose FN significantly inhibited lymphatic endothelial cell proliferation, while the pro-lymphangiogenic effect of conditioned medium from FN-treated M1 macrophages was diminished.ConclusionsFN significantly ameliorates cirrhotic PHT while reducing fibrosis, suppressing macrophage M1 polarization and inhibiting lymphangiogenesis. This may result from its modulation of multiple signaling pathways (SMAD3, STAT1, STAT3 and GSK-3β).

BACKGROUND:The potential role of N6-methyladenosine (m6A) in cancer progression has received significant attention in the past few years. The purpose of this study aimed to evaluate the impact of YTH N6-methyladenosine RNA-binding protein 2 (YTHDF2) on patient prognosis and its potential role in gastric cancer. METHODS:A total of 305 patients with clinically informative gastric cancer were identified from The Cancer Genome Atlas (TCGA) dataset, and GSE29272 and GSE84437 were used as external validation. Different m6A modulators were analyzed using the Limma package; the Cox regression models were used to determine risk factors for overall survival (OS). A 1:1 propensity score matching (PSM) analysis was used to adjust for differences in baseline clinicopathological characteristics between the YTHDF2 low and high expression groups. The Cox regression analysis was then used to identify risk factors for OS. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were used to explore the potential role and function of YTHDF2 in gastric cancer. And the effects of YTHDF2 on the growth of gastric cancer cells were detected in vivo and in vitro. RESULTS:Nineteen m6A methylation regulators were expressed in gastric cancer tissues; YTHDF2 was associated with the prognosis of gastric cancer patients. The expression level of YTHDF2, patient age, and tumor stage were independent risk factors for OS. After PSM, YTHDF2 expression led to a relatively better prognosis and staging. Patients in stage IV had a significantly worse prognosis. The expression of YTHDF2 was associated with cancer-related functions and pathways in gastric cancer. We found that YTHDF2 has lower expression in gastric cancer cells and inhibits the growth of GC cells. CONCLUSIONS:The high expression of YTHDF2 can predict a better prognosis of gastric cancer patients. YTHDF2 exerts a critical role in gastric cancer progression by inhibiting the growth of GC cells.

The zinc transporter SLC39A10 serves as a risk factor for malignant progression in gastric cancer (GC), characterized by the formation of an immunosuppressive tumor microenvironment (TME). As key cellular components within this microenvironment, both malignant cells and macrophages are influenced by SLC39A10, yet its regulatory mechanisms at the subpopulation level remain unclear. Using single-cell RNA sequencing and functional experiments, we investigated the cell-type-specific role of SLC39A10 in GC. Results demonstrated that oeSLC39A10 tumor cells exhibit activated MAPK14 signaling pathway, while tumor-associated macrophages (TAMs) display a biased M2 polarization state. These two cell populations establish intercellular communication through secretory factors IL-10 and TGF-β, synergistically promoting tumor proliferation and angiogenesis. This study identifies an SLC39A10-MAPK14-M2 macrophage regulatory axis that critically influences immune microenvironment remodeling and GC progression. Targeting this signaling axis may provide a viable therapeutic approach to alter the TME and suppress disease advancement.

BACKGROUND: To investigate the effect of laparoscopic herniorrhaphy on the treatment of unilateral Gilbert type-III inguinal hernia. METHODS: This study retrospectively reviewed medical records of 325 individuals who underwent minimally invasive laparoscopic surgery for unilateral Gilbert type-III inguinal hernias at the Ninth People's Hospital affiliated with Shanghai Jiaotong University Medical College, with data collection occurring between January 2021 and May 2024. The cohort was stratified into two surgical groups: Partial resection (n = 180) receiving transection procedures versus radical resection (n = 145) undergoing complete sac dissection, determined by intraoperative decision-making. The ages, body mass index values, operation modes, operation times, intraoperative bleeding levels, postoperative pain scores, postoperative hospital stays, postoperative seroma rates, postoperative chronic pain levels, postoperative hematoma rates, incision infection rates, and hernia recurrence rates of the patients in the two groups were analyzed and compared. RESULTS: The transection group demonstrated a marked reduction in postoperative seroma occurrence relative to the complete dissection cohort, with statistical significance confirmed (P < 0.05). There were no significant differences between the two groups in intraoperative bleeding, operation times, postoperative hospital stays, postoperative pain scores, postoperative chronic pain levels, postoperative hematoma rates, or incision infection rates (P > 0.05). Continuous surveillance spanning 12 months revealed equivalent therapeutic durability across both treatment arms, with no hernia reappearance detected. CONCLUSION: For patients requiring laparoscopic repair of unilateral Gilbert type-III inguinal hernias, intraoperative sac transection is an effective strategy, particularly in cases where the hernia sac is long and complete dissection is difficult, as it may be the preferable option and can significantly reduce the risk of postoperative seroma formation.

Gastric cancer (GC) is one of the most common malignancies in the digestive system. Many patients are found in advanced stage and have a poor prognosis. Surgery and chemotherapy remain the main treatments for gastric cancer. N6-methyladenosine (m6A) is a hot topic in tumor research in recent years. As the most common form of RNA modification in eukaryotes, m6A can regulate various stages of the RNA cycle, including RNA splicing, processing, degradation, and translation, thereby regulating RNA expression and function, playing a critical role in various pathways such as cell differentiation, development, and metabolism. The m6A demethylase can remove methyl groups on RNA, ensuring that m6A methylation is a dynamic and reversible process. As a key enzyme in the m6A methylation process, the imbalance of m6A demethylases fat mass and obesity-associated protein (FTO), AlkB homolog 5 (ALKBH5) and ALKBH3 regulate the progression of gastric cancer through various mechanisms, which is closely related to the occurrence and development of gastric cancer. These m6A demethylases regulate the signaling pathway, alter the proliferation and invasion ability of gastric cancer cells, affect its resistance to chemotherapy drugs, participate in regulating the immune response and mitochondrial metabolism of gastric cancer, and affect the growth of gastric cancer cells. They are expected to become a novel therapeutic target. This article comprehensively summarizes the molecular mechanism of m6A demethylase involved in the occurrence and development of gastric cancer, and the relationship between its expression and function, and biological characteristics of m6A demethylase were reviewed, aiming to provide new research ideas for early diagnosis and targeted treatment of gastric cancer.

The abdominal wall can be treated as a whole physiological and functional entity which is composed of multiple anatomical structures and planes. Surgical approaches and technical details that required are diverse in different area. Indeed, the abdominal wall is confined by several anatomical boundaries which make these surgical planes separated. If one could dissect these boundaries, then separated spaces could be connected, establishing an ample retromuscular/preperitoneal space to accommodate the mesh of ventral hernia repair. The concept of totally visceral sac separation (TVS) is achieved. The TVS concept is a summary of diverse ventral hernia repair techniques. Since its initiation and spread, this technique has been widely accepted and implemented by domestic surgeons due to its outstanding performance. This treatise will review the relevant anatomy as well assurgical tricks by the authors that aid in performing TVS. Some of the details are more tricky and harder to understand, thus this in-depth description of the technique.

Objective:To explore the clinical effect of laparoscopic transabdominal preperitoneal repair (TAPP) in the treatment of inguinal hernia after radical prostatectomy, and to provide theoretical basis for optimizing the surgical treatment of inguinal hernia after radical prostatectomy.Methods:A retrospective study was conducted on 68 patients with inguinal hernia and 215 patients with primary inguinal hernia after radical prostatectomy treated by TAPP in the Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University from January 2016 to December 2020. According to the causes of inguinal hernia, the patients with inguinal hernia after radical prostatectomy were the experimental group, and the patients with primary inguinal hernia were the control group. The operation time, intraoperative blood loss, intraoperative complication rate, postoperative hospital stay, postoperative pain score, postoperative complication rate and postoperative recurrence of the two groups were analyzed and compared.Results:The surgical time of the experimental group was longer than that of the control group (P<0.05). There was no statistically significant difference (P>0.05) between the two groups of patients in terms of intraoperative bleeding volume, incidence of intraoperative complications, postoperative hospitalization days, postoperative pain score, incidence of postoperative complications, and postoperative recurrence.Conclusion:TAPP is safe and effective in the treatment of inguinal hernia after radical prostatectomy. The efficacy of laparoscopic repair for inguinal hernia after radical prostatectomy is similar to that of patients with primary inguinal hernia.