Due to the important position and the role of pathology in the educational system of the medical sciences and the process of training medical students' inherent driving forces of learning,the paper proposes the remarkable teaching application value of the excellent teaching PPT of pathology(ETPP) in routine teaching and the principles and the useful skills of making ETPP which includes the emphasis of the keypoints,and the requirements of selecting figures and tables,and the plans of the color matching between the words and the backgrouds,and the moderate design of the multimedia effects in the pages.

目的 观察乳腺癌组织中表皮生长因子受体三型突变体( EGFRvⅢ)、中心体相关微管蛋白α(Tubulinα)的表达变化,并探讨其意义.方法 采用免疫组化SP法检测30例正常乳腺组织(NB组)、50例导管原位癌(DCIS组)和50例乳腺浸润性导管癌(IDC组)组织中的EGFRvⅢ、Tubulin-α.结果 IDC组EGFRvⅢ、Tubulin-α阳性表达率分别为70％( 35/50)、74％ (37/50),DCIS分别为38％ (19/50)、64％ (32/50),NB组分别为0、3％(1/30)；各组间EGFRvⅢ阳性表达率两两比较,P均＜0.05；IDC组、DCIS组Tubulin-α阳性表达率高于NB组(P均＜0.05),但IDC组与DCIS组比较,P＞0.05.乳腺癌组织中,EGFRvⅢ、Tubulin-α的表达呈正相关(r=0.909,P＜0.01).结论 乳腺癌组织中EGFRvⅢ、Tubulin-α高表达,二者在乳腺癌的发生发展过程中发挥作用.

Objective To discuss the relationship between the expression of Her2/Neu and EGFRvⅢ and the pathogenesis of the occurring and the invasion in the breast carcinoma.Methods The expressions of Her2/Neu and EGFRvⅢ were studied by S-P immunohistochemical staining in the paraffin embedded specimens,30 cases of the normal breast(NB),50 cases of ductal carcinoma in situ(DCIS)and 50 cases of invasive ductal carcinoma,no otherwise specified(IDCNOS).Results The significant increasing trend of the positive expression was observed in both Her2/Neu and EGFRvⅢ among the group of NB,DCIS,and IDCNOS(p<0.01).The higher expression of EGFRvⅢ was observed in IDCNOS than DCIS(p<0.01).The postive correlation was found between the expression of Her2/Neu and EGFRvIII in the groups of NB,DCIS and IDCNOS(r = 0.597,P< 0.001).Conclusion It seems that both Her2/Neu and EGFRvⅢ are related to the occurring of the breast carcinoma,and EGFRvⅢ might play an important role in the pathogenesis of the invasion.

Objective To evaluate the possible role of superoxide dismutase(SOD) in the mechanism of Fuzhenghuoxueqingrefang’s treating acute radiation enteritis(ARE)in rats.Methods Forty eight Wistar male rats were randomly divided into 6 groups(8 rats each group),which consisted of blank control(BC),physiological saline group(PS;9 g/L),dexamethasone group(DS;1.425mg/kg),and high,medium and low Fuzhenghuoxueqingrefang groups(HF,MF,and LF;16.67g/kg,12.5g/kg,and 8.33g/kg).The physiological saline and the drugs were administrated separately at the first day after abdominal irradiation by daily rectal clysma for 5 days.The morphologic changes(HE stain) and the serum activity of SOD were detected at the seventh day after abdominal irradiation separately.Results No obvious morphologic changes were observed in the DS,HF,and MF groups with histopathologic evaluation(HE stain),and the activity of serum SOD in the DS and MF groups were obviously higher than the PS and LF groups(F=14.199,P<0.001),but lower than the BC group(P>0.05).Conclusion Sustaining the routine activity of serum SOD effectively might play an important role in the mechanism of Fuzhenghuoxueqingrefang’s treating ARE in rats.