Objective:To understand the immune effect of hepatitis B vaccine in newborns 1-14 years after primary immunization according to a 0-1-6 month vaccination.Methods:Participants who were born in Zhengding county, Hebei between 2002 to 2016, and received a full course of primary vaccination with hepatitis B vaccine, and had no experience with booster vaccination were enrolled. An epidemiological investigation was performed, and 3-5 mL blood samples were collected to detect HBsAg, anti-HBs and anti-HBc. The positive rates of HBsAg, anti-HBs and anti-HBc were calculated to evaluate the immune effect of hepatitis B vaccine.Results:A total of 1 431 participants were included, among whom the anti-HBs positive rate was 68.55% (981/1 431) with a geometric mean concentration (GMC) of 36.65 (95% CI: 31.45-40.42) mIU/mL. The HBsAg and anti-HBc positive rates were 0.21% (3/1 431) and 0.77% (11/1 431) , respectively. The anti-HBs positive rate decreased from over 90% in 1-2 years after primary vaccination to about 50% in 12-14 years later. A significant downtrend with the extension of immunity years was observed in the anti-HBs positive rate ( χ2trend=85.101, P<0.01) . Conclusions:Hepatitis B vaccine in newborns shows a good long-term protective effect 14 years after primary vaccination.

了解志贺菌菌群及血清型分布的变迁及其对常见抗生素的耐药性特征是细菌性痢疾(菌痢)监测的一项重要内容,有助于掌握当地菌痢流行的优势菌群(血清型)及耐药谱,为菌痢的治疗、控制及疫苗的研制提供基础资料.