Objective To explore the suitable human albumin infusion speed in the liver cirrhosis patients with portal hypertension .Methods Fifty-eight portal hypertension patients need to infusion human albumin(50 ml,20%) were chosen and divided into the control group (n =30) and the experimental group ( n=28) by using the coin toss method .The control group received the infusion speed of 25 gtt/min for 45 min, and the experimental group received the infusion speed of 33 gtt/min for 30 min.The portal vein inside diameter (Dpv), mean blood flow velocity (Vpv), blood flow volume (Qpv) and the portal vein pressure measured by the color doppler ultrasound diagnostic instrument were compared at different times between two groups .Results At the end of the infusion, the Dpv,Vpv,Qpv and the portal vein pressure in the control group were (13.03 ± 2.01)mm,(9.40 ±2.06)cm/s,(782.29 ±313.02)ml/min and (2.747 ±0.348)kPa respectively, compared with the experimental group, and the differences were not statistically significant (t=-0.04,0.81,0.46,0.55, respectively;P>0.05).Conclusions It is feasible to input 10 g human albumin (50 ml,20%) during 30 min for the portal hypertension patients .

介绍了国内外关于人血白蛋白的扩容作用、运输功能、内皮稳定作用、副反应及临床应用的护理研究现状.

<正>乙型肝炎是一个严重的全球公共问题,据世界卫生组织报道:全球约20亿人感染过乙型肝炎病毒(HBV),每年约有100万人死于HBV感染所致的肝衰竭、肝硬化和原发性肝细胞癌。我国属HBV感染高流行区。而接种乙型肝炎疫苗是预防HBV感染的最有效方法[1]。从20世纪70年代开始至今已研制出3代乙型肝炎疫苗,第1代为血源性疫苗,第2代基因重组

目的 通过对临床护理路径(CNP)行SWOT分析,以充分发挥CNP的内在优势,克服劣势,抓住机遇,应对挑战.方法 自2008年5月至2009年6月我科对肝硬化合并上消化道出血患者利用CNP进行了健康教育,利用SWOT分析方法,对CNP的内在优势、劣势、发展中的机遇以及CNP所面临的挑战进行分析.结果 通过SWOT分析充分地发挥了CNP的优势,克服了内在的劣势,抓住了其发展中的机遇,能够沉着应对各种挑战,使得CNP能够顺利的进行.结论 应用SWOT分析方法对CNP进行分析是一种行之有效的方法,它可以使CNP顺利而广泛地应用于临床护理工作中.

Objective To explore the association between IL-28B genetic variation,susceptibility and spontaneous clear-ance of hepatitis C virus.Methods A total of 411 hepatitis C patients(255 male and 186 female) and 100 healthy con-trols were enrolled in the study.The rs12979860 SNP of IL-28B was identified from each cohort using pyrosequencing technology.HCV-RNA was tested in hepatitis C patients.The IL28B genetic variation was compared between hepatitis C patients and healthy controls,and chronically infected and spontaneously cleared HCV groups to assess the effect of SNP.Results The minor allele frequency(rs12979860) of Chinese population was 6%.There was no genotype and allele fre-quency(rs12979860) difference between hepatitis C patients and healthy controls(P = 0.066,P = 0.072).The level of HCV-RNA in genotype CC was significantly higher than genotype CT groups(P = 0.02).There was no significant differ-ence between genotype CC and CT among individuals who spontaneously clear HCV(P = 0.64).There was no significant difference in SNP genotype(rs12979860) between chronically infected groups and healthy controls.Conclusion The SNP genotype rs12979860 may not be the predisposing gene of hepatitis C and the CC genotype cannot predict the course of spontaneous clearance of hepatitis C.