Objective:To study the effect of baicalin used in treatment of bacterial meningitis.Methods:63 cases of bacterial meningitis were divided into two groups,32 cases of treatment group were treated with baicalin and antibiotic,31 cases of control group were treated with antibiotic.The levels of TNF-α,IL-1,NO of plasma and cerebrospinal fluid(CSF) were determined in two groups by ELISA method and Griess method to compare the curative effect,mortality and sequelae rate between two groups.Results:①The levels of TNF-α,IL-1,NO of plasma and CSF of treatment group were significantly lower than those of control group(P<0.05);②The curative effect of treatment group was significantly better than that of control group(P<0.05);③The mortality and sequelae rate of treatment group was significantly lower than those of control group(P<0.05).Conclusion:Baicalin has some effect on treatment of bacterial meningitis,the treatment mechanism is inferred to restrain the excessive release of TNF-α,IL-1,NO in the body.

Objective:To probe into the effective therapy of treating infective brain edema.Methods:87 cases of infective brain edema were divided into two groups, 44 cases of treatment group were treated with dexamethasone and mannitol, 43 cases of control group were treated with lasix and mannitol.The levels of TNF-α, IL-1, NO of CSF were determined in two group by ELISA method and Griess method to compare the curative effect, mortality and sequelae rate in two groups.Results:①The levels of TNF-α, IL-1, NO of treatment group were significantly lower than those of control group (P<0.05);②The curative effect of treatment group was significantly better than that of control group (P<0.05);③The mortality and sequelae rate of treatment group were significantly lower than that of control group (P<0.05).Conclusion:Dexamethasone was effective drug of infective brain edema of choice, and dexamethasone united mannitol could be regimen of choice.