Objective To investigate the significance of TSG101 protein expression in human malignant epithelial tumors of digestive tract. Methods TSG0101 protein was detected by immunohistochemistry assay in paraffin-embedded tissues of human esophageal carcinomas, gastric carcinomas and colorectal carcinomas. Results The expression of TSG101 protein was positively detected in 52.0% of 25 esophageal carcinomas, 28.1% of 32 gastric carcinomas and 62.5% of 40 colorectal carcinomas, respectively (P 0.05 ). And the low positive rate of TSG101 protein in high grade tumors was also found as compared with low and middle grade tumors(P 0.05 ). Conclusion The expression of TSG101 is related to grade of the human malignant epithelial tumors of digestive tract, showing a negative relationship.

Objective To detect the expression of the tumor susceptibility gene TSG101 in sarcoma to investigate the potential role of TSG101 in the pathogenesis of sarcoma.Methods 40 formalin fixed and paraffin embeded sarcoma tissues were stained by HE and immunohistochemistry to observe the expression of TSG101.Results The expression of TSG101 showed low level in sarcomas, with only 17.5% positive rate.Conclusion The defect of tumor susceptibility gene TSG101 appeared to be a frequent event in cancers derived from mesenchymal tissues. The different expressing rate of TSG101 in sarcomas and carcinomas implied a potential marker for differential diagnosis between them.