The galvanic corrosion behavior of X65 coupled with 316L stainless steel in simulated production water was investigated by electrochemical methods.The results show that when the area ratios of X65/316L were 2,1 and 0.5,the couple potentials of X65 and 316L in the simulated production water with pH 7.15 were in the range of-708 mV to-735 mV(SCE).When the area ratio increased,the anodic galvanic current density increased,while the cathodic galvanic current density almost was not changed.The galvanic effect increased with increasing the cathode/anode area ratio.When the area ratio was 1∶1,the galvanic current density increased with decreasing the pH value.

Objective To explore the application and efficacy of the low molecular weight heparin calcium combined with ambroxol in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods Seventy-five patients were randomly divided into the treatment group(n=45)and control group(n=30).The patients of the two groups were treated with conventional therapy.In the treatment group,the low molecular weight heparin calcium and ambroxol were added in the therapy.The changes in the indicators and clinical symptoms were observed between the two groups before and after the treatment.Results Compared with the control group,there was significant difference in the clinical symptom score,the average days of hospital stay,the serum C-reactive protein(all P0.05).Compared in the same group before and after the treatment,there was significant difference in blood gas analysis and lung function(P0.05)in the treatment group(P0.01),and there was significant difference in blood gas analysis and lung function between the two groups(P0.05).Conclusion The clinical therapeutic effect is exact in the treatment of AECOPD with low-molecular-weight heparin and inhalation ambroxol,so it is worthy to spread widely.

目的探讨糖皮质激素对COPD患者焦虑和抑郁症状的影响。方法选取82例COPD患者,随机分为激素治疗组(41例)和对照组(41例)。经过不同的治疗方案后,对两组患者的焦虑和抑郁症状进行评分比较。结果应用激素的患者在治疗后其抑郁和焦虑症状评分较之治疗前均有显著增加(P<0.05)。差异有统计学意义(P<0.01)。结论糖皮质激素类药物很可能有加重COPD患者焦虑与抑郁症状的副作用。

Taking for example the Changsha Luyun Road,the application of heavy tamping method in treatment of high filled roadbed,the roadbed construction quality control process and measures were introduced in this paper.

AIM: To develop an analytical method based on LC-MS/MS for the quantification of lisinopril in human plasma and the assessment of bioequivalence for two kinds of lisinopril tablets in Chinese healthy male volunteers. METHODS: Plasma samples of 20 healthy male volunteers, who were administrated with a single oral dose of lisinopril test tablets (10 mg) and reference tablets (10 mg) according to a random 2-way crossover design, were prepared by a simple protein precipitation and then were determined by LC-MS/MS method. RESULTS: The main pharmacokinetic parameters of lisinopril test tablets and reference tablets were as follows: cmax(54±s 21) and (53±23)μg·L-1, tmax(6.4±1.4) and (6.7±1.1) h, AUC0-36(569±244) and (566±269)μg·h·L-1, AUC0-∞(589±250) and (587±268)μg·h·L-1, respectively. Calculating by AUC0-36, the relative bioavailability of lisinopril test tablets was (102±8) %. CONCLUSION: The analytical method based on LC-MS/MS for quantification and assessment of bioequivalence is simple, rapid and sensitive, proving the bioequivalence of lisinopril test tablets to the reference tablets.