Objective. To research the molecular mechanism of compound Danshen tablets in the treatment of hepatic fibrosis through network pharmacology. Methods. Traditional Chinese medicine systems pharmacology (TCMSP) and online Mendelian inheritance in man (OMIM) databases were searched for compound Danshen tablets’ active ingredients o and hepatic fibrosis-related genes. The network enrichment of the targets of “herb-compound-target” was visualized and analyzed using Cytoscape software. Then, the screened target genes were used to construct a protein-protein interaction network. The DAVID enrichment database (the database for annotation, visualization, and integrated discovery) was adopted for GO (Gene Ontology) enrichment and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway enrichment of vital nodes. Results. The results yielded 234 targets of compound Danshen tablets; ten important targets (TNF, IL-10, TGF-β1, EGF, CXCL16, CCL21, SERPINB5, SERPINA1, SOD2, and PPIG) for reversing hepatic fibrosis; and four core targets (TNF, IL-10, TGF-1, and EGF). In addition, KEGG enrichment analysis showed that compound Danshen tablets mainly involved FoxO and MAPK signaling pathways, as the key signaling pathways in the treatment of hepatic fibrosis. Conclusion. TNF, IL-10, TGF-1, and EGF and FOXO and MAPK signaling pathways play a key role in the pathogenesis of hepatic fibrosis. Based on the results of this study, the mechanism of action of compound Danshen tablets in the treatment of hepatic fibrosis may be associated with the regulation of FoxO and MAPK signaling pathways and inhibition of TNF, IL-10, TGF-1, and EGF.

Objective. To research the molecular mechanism of compound Danshen tablets in the treatment of hepatic fibrosis through network pharmacology. Methods. Traditional Chinese medicine systems pharmacology (TCMSP) and online Mendelian inheritance in man (OMIM) databases were searched for compound Danshen tablets' active ingredients o and hepatic fibrosis-related genes. The network enrichment of the targets of "herb-compound-target" was visualized and analyzed using Cytoscape software. Then, the screened target genes were used to construct a protein-protein interaction network. The DAVID enrichment database (the database for annotation, visualization, and integrated discovery) was adopted for GO (Gene Ontology) enrichment and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway enrichment of vital nodes. Results. The results yielded 234 targets of compound Danshen tablets; ten important targets (TNF, IL-10, TGF-beta 1, EGF, CXCL16, CCL21, SERPINB5, SERPINA1, SOD2, and PPIG) for reversing hepatic fibrosis; and four core targets (TNF, IL-10, TGF-1, and EGF). In addition, KEGG enrichment analysis showed that compound Danshen tablets mainly involved FoxO and MAPK signaling pathways, as the key signaling pathways in the treatment of hepatic fibrosis. Conclusion. TNF, IL-10, TGF-1, and EGF and FOXO and MAPK signaling pathways play a key role in the pathogenesis of hepatic fibrosis. Based on the results of this study, the mechanism of action of compound Danshen tablets in the treatment of hepatic fibrosis may be associated with the regulation of FoxO and MAPK signaling pathways and inhibition of TNF, IL-10, TGF-1, and EGF.

For the safety problems of internal medicine intravenous infusion,we carry out meticulous management,establish quality control system of intravenous infusion safety management,and formulate quality control plan.We collect and analyse the potential unsafety factors in the various departments of internal medicine.We have revised the intravenous infusion system and procedures,formulated standards for safety inspection of intravenous fluids,and standardized the admission system for nurses.We carry out training on intravenous infusion related knowledge for nursing staff,carry out meticulous management of venous transfusion links,and actively carry out learning and communication.All these measures have greatly enhanced the safety awareness of the nursing staff.The safety index of intravenous infusion for liver diseases was preliminarily summarized.The use rate of the safe indwelling needle was increased from 30.60％ to 92.30％,the rate of appropriate rate of drop speed increased from 68.45％ to 93.20％,the three sign standard rate rose from 75.20％ to 95.10％,and the patient's satisfaction with infusion increased from 85.60％ to 96.82％.Meticulous management can improve the safety of the internal medicine intravenous infusion as a whole.

目的:评价艾灸床治疗肝硬化脾功能亢进患者的疗效.方法:对2016年3月至2017年3月43例肝硬化脾功能亢进住院患者进行分组,治疗组患者23例经艾灸床治疗,对照组患者20例经升血细胞药物治疗.对两组患者进行后期随访,随访指标主要为外周血白细胞、中性粒细胞、红细胞、血小板计数及血红蛋白,对比分析停药后的后期效果.结果:对照组患者治疗3天白细胞上升至超出基线范围,治疗前后分别对比白细胞、中性粒细胞、血小板计数,差异均有统计学意义(P＜0.05).治疗2周及以后,对照组患者白细胞、中性粒细胞、血小板下降,治疗组患者白细胞、血小板仍可稳定在高于基线水平,两组比较,差异有统计学意义(P＜0.05).对照组患者在停药2周后三系细胞普遍恢复至基线水平,甚至个别较治疗前下降.治疗组患者在治疗后2周三系细胞较治疗前升高,治疗前后对比,差异有统计学意义(P＜0.05).结论:艾灸床用于肝硬化脾功能亢进患者的辅助治疗,能使三系细胞稳步上升并长期稳定在高于基线范围,具有良好的治疗作用,值得临床推广应用.

TCM nursing is an important part of traditional Chinese medicine, it is rich in Chinese traditional culture and full of humane care. TCM nursing develops under the guidance of TCM theory and contains mental nursing, diet nursing and traditional Chinese medicine nursing technology, which are rich in characteristic and advantages. This thesis introduces the mental nursing, diet nursing and symptomatical nursing of TCM nursing in caring patient in initial stage, middle stage of treatment, late treatment respectively based on the analysis of the adverse drug reaction in the treatment of chronic hepatitis C with long acting interferon combined with ribavirin, during which the features of TCM nursing were manifested comprehensively and the connotation of the nursing theory was enriched and expanded.

Objective:To discuss the application effect of clinical nursing pathway on the health education of patients with osteoporosis.Methods: 100 patients with osteoporosis were randomly divided into observation group and control group(50 cases for each group).The patients in the observation group were given health education by following clinical nursing pathway and the patients in the control group received conventional health education.The up-to-standard rate of health education,the degree of patient's satisfaction with nursing service,the mean hospitalization days,hospitalization expenses and treatment compliance of the patients were compared between the two groups.Results: The differences in the comparison of the up-to-standard rate of health education,the hospitalization days and expenses,the degree of patient's satisfaction and treatment compliance of the patients were statistically significant(P<0.01).Conclusion: The application of clinical nursing pathway can effectively improve the effectiveness of health education of patients with osteoporosis.