Objective To investigate the effect of different doses of sodium oxybate on the convulsions and mortality rate of mice with ropivacaine poisoning.Methods 40 mice were randomized into 4 groups(n=10 each) and received intraperitoneal injections of sodium oxybate of three different doses or the same volume of normal saline,respectively.5 minutes later,all the mice received an intraperitoneal injection of ropivacaine in a toxic dose and the convulsion latency,duration,seizure incidence and mortality of the 40 mice were observed and recorded.Results Compared with the normal saline group,the sodium oxybate groups had a lower convulsion rate,longer latency of the convulsion,shorter duration and reduced mortality.Conclusion Sodium oxybate could decrease ropivacaine toxicity with a dose-dependent response.