将实验室废弃的强度等级为C30混凝土试块经人工破碎后通过筛选得到粒径为20～50 mm的再生粗骨料.为探究科氏芽孢杆菌矿化沉积对再生粗骨料的影响,研制了不同pH条件科氏芽孢杆菌菌液浸泡处理的再生粗骨料.利用科氏芽孢杆菌菌液浸泡处理后的再生粗骨料(取代率选用20％)制备再生骨料混凝土,开展了再生骨料混凝土试件的单轴抗压强度和声发射损伤特征试验,分析了不同pH条件的科氏芽孢杆菌矿化沉积再生粗骨料对浸泡液残余Ca2+浓度、混凝土峰值抗压强度和损伤演化的影响.试验结果表明:科氏芽孢杆菌菌液浸泡处理再生粗骨料后,残余Ca2+浓度随浸泡液pH值的减小而减少,科氏芽孢杆菌菌液浸泡能有效改善再生粗骨料的密实性,且酸性条件下效果最好;再生粗骨料经酸性环境的科氏芽孢杆菌菌液浸泡处理后制备的再生骨料混凝土的峰值强度有明显的提高;在抗压过程中,损伤演化减缓,损伤劣化程度降低,当浸泡液从pH=8到pH=5时,再生骨料混凝土损伤变量逐渐减小且累积损伤明显降低.研究成果可为微生物改良再生骨料的实际应用提供参考.

It had been reported miR‐182 was down‐regulated after intestinal ischaemia/reperfusion (I/R) damage. However, its role and potential mechanisms are still unknown. This study was aimed to elucidate the function of miR‐182 in intestinal I/R injury and the underlying mechanisms. The model of intestinal injury was constructed in wild‐type and Deptor knockout (KO) mice. Haematoxylin‐eosin staining, Chiu's score and diamine oxidase were utilized to detect intestinal damage. RT‐qPCR assay was used to detected miR‐182 expression. Electronic microscopy was used to detect autophagosome. Western blot was applied to detect the expression of Deptor, S6/pS6, LC3‐II/LC3‐I and p62. Dual‐luciferase reporter assay was used to verify the relationship between miR‐182 and Deptor. The results showed miR‐182 was down‐regulated following intestinal I/R. Up‐regulation of miR‐182 reduced intestinal damage, autophagy, Deptor expression and enhanced mTOR activity following intestinal I/R. Moreover, suppression of autophagy reduced intestinal damage and inhibition of mTOR by rapamycin aggravated intestinal damage following intestinal I/R. Besides, damage of intestine was reduced and mTOR activity was enhanced in Deptor KO mice. In addition, Deptor was the target gene of miR‐182 and was indispensable for the protection of miR‐182 on intestine under I/R condition. Together, our research implicated up‐regulation of miR‐182 inhibited autophagy to alleviate intestinal I/R injury via mTOR by targeting Deptor.

Background. Intestinal ischemia/reperfusion (I/R) injury is a severe condition associated with high morbidity and mortality. Ischemic preconditioning (IPC) had been found to be the most promising strategies against I/R injury. However, the potential molecular mechanisms underlying the protective effect of IPC have not been fully disclosed. Micro-RNA182 (miR-1 82) is closely related to apoptosis and plays an important role in UR injury. Our recent study demonstrated that miR-182 was down-regulated in the intestinal mucosa after UR injury. However, whether miR-182 is involved in the protective effects of IPC in the setting of intestinal I/R injury is unknown. Aims. To investigate the role of miR-182 in the protective effect of IPC in intestine after I/R injury and potential mechanisms. Methods. AntagomiR-182 was pretreated before IPC in mice with intestinal I/R injury. MiR-182 mimic was administered before oxygen and glucose deprivation and reperfusion (OGD/R) in mice intestinal mucosa epithelial (MIME) cells. Results. IPC partially prevented the downregulation of miR-182 in mice, which was blocked by pretreatment with antagomiR-182. Compared with the IPC group, pretreatment with antagomiR-182 further increased Chiu's scores and diamine oxidase activities. Meanwhile, apoptotic cells and cleaved caspase-3 expression were increased. Compared with the OGD/R group, pretreatment with miR-182 mimic prevented the downregulation of miR-182, improved cell survival, reduced apoptosis and cleaved caspase-3 expression in MIME cells. Conclusions. The downregulation of miR-182 was partially prevented by IPC, which was involved in IPC induced intestinal protection, and the mechanisms may be associated with inhibition of apoptosis. (C) 2019 IMSS. Published by Elsevier Inc.

Background: Endovascular embolization was successfully used in treatment of brain arteriovenous malformations (bAVM), respectively or in combination with surgical resection. Deliberate employment of post-operative hypotension was widely recommended by neurosurgeons. Researches on predictors of difficulties in deliberate postoperative hypotension remain scarce. This study aimed to analyze the potential risk factors of difficult cases of deliberate post-operative hypotension. Methods: We retrospectively reviewed all patients who received bAVM embolization between January 2010 and December 2015. Demographic features, clinical presentation, AVM characteristics, peri-operative medication, hemodynamic features, treatment-related information and outcome-related data were recorded. Univariate analysis and logistic regression were performed to find out associated risk factors. Results: Difficulty in deliberate postoperative hypotension was observed in 75 patients the first postoperative day. Logistic regression indicated that higher Sptzler-Martin (S-M) grade was an independent risk factor of difficult deliberate postoperative hypotension following embolization (OR=2.058; 95% CI, 1.364-3.105; P=0.001). While infra-operative dexmedetomidinc administration was a potential independent protective factor (OR=0.356; 95% CI, 0.133-0.956; P=0.040). Conclusions: Higher S-M grade was an independent risk factor of difficult cases of deliberate postoperative hypotension after endovascular embolization, while intra-operative dexmedetomidine administration was potential protective predictor.

CIPS is the best advanced technique of protection coating and cathode protection monitoring method of buried pipelines,it can figure out the effect of pipeline CP,effectively eliminate the impact of IR-drop,point out the severity of fault and takes sample of data automatically.It combines with the interval potential and surface reference techniques,can be used to the check the cathode protection potential of pipeline,assess the effect of cathode protection,find out the status of pipeline protection coating and fault monitoring.

According to the forest resources investigation materials provided by the Forestry Department of Yangquan Coal Industry(Group)Co.,Ltd,this paper,by means of forest stock volume,estimates the biomass,carbon storage and carbon density of Pinus tabulaeformis,Larch and arborvitae in 2005 and 2009,and analyzes their temporal changes and spatial distributions.It is shown from the result that the total forest carbon reserves in 2009 increase 234 002.93MgC comparing with that in 2005,and the growth rate is 36.41%,which proves that the three kinds of tree species all have the abilities of carbon sequestration,and the forest play a good role in carbon sinks.Besides,it is also illustrated that the carbon density of the arborvitae grows fastest and among the three tree species,the arborvitae is the most suitable plant in this region.

A system for HDTV image tracking based on FPGA and DSP is designed.The thesis mainly achieves HDTV image(definition 1 600×1 200,frame ratio 68 f/s) capturing,target tracking and video out.The system interface adopts the technology of camera link.

芹菜种子经过超干处理,在常温下贮藏一段时间后,其发芽率、发芽指数、活力指数比常规贮藏种子高且差异显著。超干贮藏种子外渗液的电导率和丙二醛（MDA）含量显著低于常规贮藏种子;超干种子的超氧化物歧化酶（SOD）、过氧化物酶（POD）、过氧化氢酶（CAT）等活性高于常规贮藏种子。