A clinical case report is given of a 65 year old female patient with obesity, arterial hypertension, diabetes mellitus, and syndrome of obstructive sleep apnoe associated with multiple episodes of non-sustained ventricular tachycardia, with a positive effect of CPAP therapy.

Obstructive Sleep Apnea Syndrome (OSAS) is an additional independent factor of growth of cardiovascular mortality. Special role disturbances of respiration during sleep play in development of nocturnal cardiac arrhythmias. Approaches to correction of OSAS associated nocturnal bradyarrhythmias have substantially changed during recent years. We present report of a clinical case in which we detected relation of nocturnal bradyarrhythmias to OSAS. Adequate correction of OSAS by continuous positive airway pressure therapy resulted in complete elimination of bradyarrhythmias during night time. This allowed to avoid implantation of permanent pacemaker.

We studied endothelial function on 80 male patients (mean age 72.5 ±2.7) with hypertension III risk 3 and 4 by Doppler measuring of brachial artery diameter in rest and during probe with reactive hyperthermia, determining serum level of total nitric oxide production and pro and antioxidative activity of blood. We revealed disturbances of endothelial dependent vasodilatation during probe with reactive hyperthermia and decrease of brachial artery diameter growth compare to control. Disturbances of endothelial dependent vasodilatation accompanied by decrease of endothelial nitric oxide production and expression of endothelial dysfunction correlated with pro and antioxidative blood activity disbalance.

Clinical-genetic aspects of polymorphic variants of TNF-? gene, interleukin-1? gene and interleukin-1 receptor antagonist gene influence on the initiation and development of CHF in patients with CHD are presented in the article. We studied 165 CHD patients with NYHA Class I-IV CHF (121 males and 44 females, mean age 56,7±5,3 years). Control group consisted of 114 persons (54 males and 60 females, mean age 53,2±4,9 years). The level of proinflammatory cytokine TNF-? in CHF patients was shown to be associated with high risk of CHF development and severity degree of CHF clinical manifestations. Associations between polymorphous variants of IL-1Ra gene (VNTR intron 2) and CHF development were not revealed. Association between serum TNF-? level and polymorphism of TNF-? and IL-1? genes with high risk of CHF development and severity of disease was found as well.