Inflammatory bowel diseases (IBD) - ulcerative colitis (UC) and Crohn’s disease (CD) are characterized by a specific clinic: diarrhea, the presence of blood in the stool, abdominal pain, general weakness. However, IBD can be combined with other bowel diseases, for example, with the bacterial overgrowth syndrome (BOS). BOS may not be suspected due to the similarity of symptoms with manifestations of exacerbation of CD or UC, the symptoms of BOS can be regarded only as a manifestation of IBD, which leads to incorrect treatment tactics. In this article, we demonstrate the clinical case of such a combination.

Research objective: to study the frequency of gastrointestinal symptoms in patients with inflammatory bowel disease (IBD) depending on the presence of the small intestinal bacterial overgrowth (SIBO). Materials and methods of the study: The study included 152 patients with IBD. All patients would be given a hydrogen breath test (VDT) with lactulose to diagnose SIBO. The analysis of gastrointestinal symptoms in patients depending on the presence of SIBO, as well as the dynamics of symptoms after its correction was carried out. Results: The frequency of SIBO in patients with IBD was 48%. Patients with SIBO were more likely to have symptoms: diarrhea, bloating, flatulence, weakness, whining and irritability. After a 2-week course of correction of SIBO, patients had a decrease in the frequency of these symptoms. Conclusion: The data obtained indicate a high frequency of SIBO in patients with IBD. SIBO is associated with symptoms that may accompany an acute attack of the IBD. The diagnosis of SIBO should be included in routine practice in patients with acute attack of IBD for selection of adequate therapy, which will include correction of microbiota disorders and will not lead to inappropriate change of basic therapy.

Patients with inflammatory bowel disease (IBD) are characterized by chronic recurrent course, frequent attacks, the presence of extraintestinal manifestations and the occurrence of complications, which leads to a decrease in the quality of life. One of the concomitant conditions in patients with IBD is the small intestinal bacterial overgrowth syndrome (SIBO), which has common clinical manifestations. There is practically no research on the effect of concomitant SIBO in patients with IBD on the quality of life (QOL). Therefore, the study of QOL in patients with IBD with SIBO is an important task for optimizing treatment. Purpose: to study the quality of life in patients with IBD, depending on the presence of SIBO. Material and methods of the study: patients from the registry of inflammatory bowel diseases in Novosibirsk who underwent a hydrogen respiratory test (HBT) on the device «Gastro+». The QOL indicators were determined using the Russian version of the SF-36 and IBDQ questionnaire. Results: in 152 patients with IBD, in whom HBT was carried out, the prevalence of SIBO was 48.0 % (with ulcerative colitis - 45.7 %, with Crohn’s disease - 50.7 %). In the scales of the SF-36 and IBDQ questionnaire significant decrease in QOL values was revealed in patients with IBD with positive results of HBT in comparison with patients with negative results of HBT. After a 2-week course of rifaximin intake, values increased in almost all scales of the SF-36 and IBDQ questionnaires. Conclusion: The obtained data confirm the necessity of correction of SIBO as an independent clinical task that significantly affects QOL of patients with IBD.

Inflammatory bowel diseases (IBD) are chronic recurrent immune-mediated inflammation of the gastrointestinal tract. Now it is not unified system of monitoring patients with IBD in Russia, but there is information from different regions about the prevalence of disease. There are the registers in few big cities. From 2003 the registers of IBD have been done in Novosibirsk. The register data can give us the possibility to estimate the various real-time data of the disease, to analyze the effect of the treatment , to evaluate risk factors for the disease in real clinical practice. Among the patients with ulcerative colitis decreased the number of patients with recurrent and continuous increase in the number of patients with distal forms, which is probably due to the more skillful conduct of patients. In general, it decreased the number of patients with Crohn's disease with continuously relapsing course option, reflecting, perhaps, improved treatment. Decline in the proportion of persons with the localization process, only in the colon, which is associated with greater availability of diagnostic methods for destruction of the small intestine. The registry was created in April 2012 and includes patients registered up to October 2015.

This article presents a case of Crohn’s disease in a man who was veracity of 30 years from the onset of the disease. This case demonstrating complexity of diagnostic search, even with the classic version of the disease. And it demonstrates the need for a thorough medical history, differential diagnosis.

During past years incidence and prevalence of microscopic colitis (MC) have increased, that is possible caused to the improvement of knowledge of doctors about the disease. This article contain modern views on epidemiology, diagnostic and variant of microscopic colitis treatment. A typical clinical picture of МС in the form of recurrent a watery diarrhea, with the absence of pathologic changes at roentgenologic and endoscopic investigations is described with the example of a clinical case.