Aim: To study the influence of different intensities of rehabilitation therapy on the prognosis in patients with stroke during the acute period. Methods: Totally 74 patients with acute stroke were randomly assigned into treatment group (receiving intense rehabilitation therapy for six months) and control group (receiving common rehabilitation therapy for six months). All the patients were evaluated with Fugl-Meyer assessment (FMA), national institute of health stroke scale (NIHSS) and modified Barthel index (MBI) before and six months after rehabilitation training, and scales of western aphasia battery (WAB) were also assessed in patients with aphasia, and the functional recovery between the two groups were compared. Results: There were no significant differences in the scores of FMA (29.35 ± 22.67 vs 30.26 ± 19.19), NIHSS (8.94 ± 3.64 vs 8.75 ± 4.26), MBI (23.82 ± 13.84 vs 25.47 ± 15.57) and WAB (60.23 ± 18.50 vs 57.33 ± 16.79) before treatment between the two groups ( P > 0.05). There were obvious improvements in the functional recovery six months after treatment, and the scores of FMA (85.84 ± 19.68 vs 71.59 ± 25.21), NIHSS (2.01 ± 0.034) vs (3.53 ± 0.54) and MBI (88.24 ± 17.95) vs 74.42 ± 24.70) were significantly different between the two groups(P < 0.05), and the difference of the scores on WAB (87.74 ± 13.9) vs 71.24 ± 15.63) were extremely significant (P < 0.01). Conclusion: Proper intense rehabilitation may enhance the prognosis of function in patients with stroke, especially in those with aphasia.

目的 观察磷脂酶C抑制剂苯甲基磺酰氟 （ phenylmethylsulfonylfluoride ,PMSF）对脑缺血时脑细胞膜游离脂肪酸 （freefattyacid ,FFA）释放的治疗及保护作用。方法 选用雄性SD大鼠局灶性脑缺血模型 ,气 液色谱分析技术观察了脑缺血前后应用PMSF对不同缺血时间点脑细胞膜FFA含量的变化。结果 PMSF主要抑制缺血早期磷脂酰肌醇和缺血后期磷脂酰乙醇胺、磷脂酰胆碱的FFA释放。结论 多不饱和脂肪酸 （C2 0∶4、C2 2∶6 ）积聚是反映缺血性脑损伤程度的重要指标 ,PMSF对缺血脑组织有一定的保护及治疗作用